Abstract：
:Understanding the molecular parameters that regulate cross-species transmission and host adaptation of potential pathogens is crucial to control emerging infectious disease. Although microbial pathotype diversity is conventionally associated with gene gain or loss, the role of pathoadaptive nonsynonymous single-nucleotide polymorphisms (nsSNPs) has not been systematically evaluated. Here, our genome-wide analysis of core genes within Salmonella enterica serovar Typhimurium genomes reveals a high degree of allelic variation in surface-exposed molecules, including adhesins that promote host colonization. Subsequent multinomial logistic regression, MultiPhen and Random Forest analyses of known/suspected adhesins from 580 independent Typhimurium isolates identifies distinct host-specific nsSNP signatures. Moreover, population and functional analyses of host-associated nsSNPs for FimH, the type 1 fimbrial adhesin, highlights the role of key allelic residues in host-specific adherence in vitro. Together, our data provide the first concrete evidence that functional differences between allelic variants of bacterial proteins likely contribute to pathoadaption to diverse hosts.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Yue M,Han X,De Masi L,Zhu C,Ma X,Zhang J,Wu R,Schmieder R,Kaushik RS,Fraser GP,Zhao S,McDermott PF,Weill FX,Mainil JG,Arze C,Fricke WF,Edwards RA,Brisson D,Zhang NR,Rankin SC,Schifferli DMdoi
10.1038/ncomms9754subject
Has Abstractpub_date
2015-10-30 00:00:00pages
8754issn
2041-1723pii
ncomms9754journal_volume
6pub_type
杂志文章abstract：:Mutators represent a successful strategy in rapidly adapting asexual populations, but theory predicts their eventual extinction due to their unsustainably large deleterious load. While antimutator invasions have been documented experimentally, important discrepancies among studies remain currently unexplained. Here we...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11217-6
更新日期：2019-07-15 00:00:00
abstract：:Device applications of graphene such as ultrafast transistors and photodetectors benefit from the combination of both high-quality p- and n-doped components prepared in a large-scale manner with spatial control and seamless connection. Here we develop a well-controlled chemical vapour deposition process for direct gro...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2286
更新日期：2012-01-01 00:00:00
abstract：:Cells couple growth with division and regulate size in response to nutrient availability. In rod-shaped fission yeast, cell-size control occurs at mitotic commitment. An important regulator is the DYRK-family kinase Pom1, which forms gradients from cell poles and inhibits the mitotic activator Cdr2, itself localized a...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9445
更新日期：2015-10-07 00:00:00
abstract：:Microbial biofilm formation on indwelling medical devices causes persistent infections that cannot be cured with conventional antibiotics. To address this unmet challenge, we engineer tunable active surface topographies with micron-sized pillars that can beat at a programmable frequency and force level in an electroma...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16055-5
更新日期：2020-05-05 00:00:00
abstract：:Optical microscopy improves in resolution and signal-to-noise ratio by correcting for the system's point spread function; a measure of how a point source is resolved, typically determined by imaging nanospheres. Optical-resolution optoacoustic (photoacoustic) microscopy could be similarly corrected, especially to acco...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16565-2
更新日期：2020-06-09 00:00:00
abstract：:The direct transformation of cellulose, which is the main component of lignocellulosic biomass, into building-block chemicals is the key to establishing biomass-based sustainable chemical processes. Only limited successes have been achieved for such transformations under mild conditions. Here we report the simple and ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms3141
更新日期：2013-01-01 00:00:00
abstract：:Bryostatin is in clinical trials for Alzheimer's disease, cancer, and HIV/AIDS eradication. It binds to protein kinase C competitively with diacylglycerol, the endogenous protein kinase C regulator, and plant-derived phorbol esters, but each ligand induces different activities. Determination of the structural origin f...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-016-0015-8
更新日期：2017-02-23 00:00:00
abstract：:Direct reciprocity is a mechanism for cooperation among humans. Many of our daily interactions are repeated. We interact repeatedly with our family, friends, colleagues, members of the local and even global community. In the theory of repeated games, it is a tacit assumption that the various games that a person plays ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02721-8
更新日期：2018-02-07 00:00:00
abstract：:Electronic structure heterogeneities are ubiquitous in two-dimensional graphene and profoundly impact the transport properties of this material. Here we show the mapping of discrete electronic domains within a single graphene sheet using scanning transmission X-ray microscopy in conjunction with ab initio density func...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1376
更新日期：2011-06-28 00:00:00
abstract：:A challenge for neuroscience is to understand the conscious and unconscious processes underlying construction of willed actions. We investigated the neural substrate of human motor awareness during awake brain surgery. In a first experiment, awake patients performed a voluntary hand motor task and verbally monitored t...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-14517-4
更新日期：2020-02-04 00:00:00
abstract：:Male pattern baldness (MPB) is a sex-limited, age-related, complex trait. We study MPB genetics in 205,327 European males from the UK Biobank. Here we show that MPB is strongly heritable and polygenic, with pedigree-heritability of 0.62 (SE = 0.03) estimated from close relatives, and SNP-heritability of 0.39 (SE = 0.0...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07862-y
更新日期：2018-12-20 00:00:00
abstract：:Gold recovery using environmentally benign chemistry is imperative from an environmental perspective. Here we report the spontaneous assembly of a one-dimensional supramolecular complex with an extended {[K(OH₂)₆][AuBr₄](α-cyclodextrin)₂}n chain superstructure formed during the rapid co-precipitation of α-cyclodextrin...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2891
更新日期：2013-01-01 00:00:00
abstract：:Human intestinal bacteria produce butyrate, which has signalling properties and can be used as energy source by enterocytes thus influencing colonic health. However, the pathways and the identity of bacteria involved in this process remain unclear. Here we describe the isolation from the human intestine of Intestinimo...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10062
更新日期：2015-12-01 00:00:00
abstract：:Mesostriatal dopaminergic neurons possess extensively branched axonal arbours. Whether action potentials are converted to dopamine output in the striatum will be influenced dynamically and critically by axonal properties and mechanisms that are poorly understood. Here, we address the roles for mechanisms governing rel...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12264-9
更新日期：2019-09-19 00:00:00
abstract：:The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs in KITLG and a regio...
journal_title：Nature communications
pub_type： 杂志文章,meta分析
doi：10.1038/s41467-018-06649-5
更新日期：2018-11-14 00:00:00
abstract：:Dynamics of molecules in the solid state holds promise for connecting molecular behaviors with properties of bulk materials. Solid-state dynamics of [60]fullerene (C60) is controlled by intimate intermolecular contacts and results in restricted motions of a ratchet phase at low temperatures. Manipulation of the solid-...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-04325-2
更新日期：2018-05-15 00:00:00
abstract：:Oxygenic photosynthetic organisms perform solar energy conversion of water and CO2 to O2 and sugar at a broad range of wavelengths and light intensities. These cells also metabolize sugars using a respiratory system that functionally overlaps the photosynthetic apparatus. In this study, we describe the harvesting of p...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-04613-x
更新日期：2018-06-04 00:00:00
abstract：:Despite their importance as mechanistic models for heterogeneous Haber Bosch ammonia synthesis from dinitrogen and dihydrogen, homogeneous molecular terminal metal-nitrides are notoriously unreactive towards dihydrogen, and only a few electron-rich, low-coordinate variants demonstrate any hydrogenolysis chemistry. Her...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-14221-y
更新日期：2020-01-17 00:00:00
abstract：:Macrophages serve multiple functions including immune regulation, morphogenesis, tissue homeostasis and healing reactions. The current paradigm holds that mammary gland macrophages first arise postnatally during the prepubertal period from the bone marrow-derived monocytes. Here we delineate the origins of tissue-resi...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-08065-1
更新日期：2019-01-17 00:00:00
abstract：:The presence and absence of RNA modifications regulates RNA metabolism by modulating the binding of writer, reader, and eraser proteins. For 5-methylcytosine (m5C) however, it is largely unknown how it recruits or repels RNA-binding proteins. Here, we decipher the consequences of m5C deposition into the abundant non-c...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-10020-7
更新日期：2019-06-11 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 已发布勘误
doi：10.1038/s41467-020-14680-8
更新日期：2020-02-19 00:00:00
abstract：:The Gibbs energy, G, determines the equilibrium conditions of chemical reactions and materials stability. Despite this fundamental and ubiquitous role, G has been tabulated for only a small fraction of known inorganic compounds, impeding a comprehensive perspective on the effects of temperature and composition on mate...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06682-4
更新日期：2018-10-09 00:00:00
abstract：:Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent reason for antibiotic treatment in children. Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (rs2932989, Pmeta=2....
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12792
更新日期：2016-09-28 00:00:00
abstract：:Innovations in soft material synthesis and fabrication technologies have led to the development of integrated soft electronic devices. Such soft devices offer opportunities to interact with biological cells, mimicking their soft environment. However, existing fabrication technologies cannot create the submicron-scale,...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-14814-y
更新日期：2020-02-21 00:00:00
abstract：:Longevity is influenced by genetic and environmental factors, but the underlying mechanisms remain elusive. Here, we functionally characterise a Drosophila small nucleolar RNA (snoRNA), named jouvence whose loss of function reduces lifespan. The genomic region of jouvence rescues the longevity in mutant, while its ove...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-14784-1
更新日期：2020-02-20 00:00:00
abstract：:New Zealand moa (Aves: Dinornithiformes) are the only late Quaternary megafauna whose extinction was clearly caused by humans. New Zealand offers the best opportunity to estimate the number of people involved in a megafaunal extinction event because, uniquely, both the Polynesian settlement of New Zealand and moa exti...
journal_title：Nature communications
pub_type： 历史文章,杂志文章
doi：10.1038/ncomms6436
更新日期：2014-11-07 00:00:00
abstract：:Competing interactions in the so-called spin-ice compounds stabilize a frustrated ground state with finite zero-point entropy and, interestingly, emergent magnetic monopole excitations. The properties of these monopoles are at the focus of recent research with particular emphasis on their quantum dynamics. It is predi...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5853
更新日期：2014-09-04 00:00:00
abstract：:Post-translational protein modifications are systems designed to expand restricted genomic information through functional conversion of target molecules. Ubiquitin-like post-translational modifiers regulate numerous cellular events through their covalent linkages to target protein(s) by an enzymatic cascade analogous ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1182
更新日期：2011-02-08 00:00:00
abstract：:Proximity-ligation methods such as Hi-C allow us to map physical DNA-DNA interactions along the genome, and reveal its organization into topologically associating domains (TADs). As the Hi-C data accumulate, computational methods were developed for identifying domain borders in multiple cell types and organisms. Here,...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02386-3
更新日期：2017-12-21 00:00:00
abstract：:Oxygen defect control has long been considered an important route to functionalizing complex oxide films. However, the nature of oxygen defects in thin films is often not investigated beyond basic redox chemistry. One of the model examples for oxygen-defect studies is the layered Ruddlesden-Popper phase La2-xSr x CuO4...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02568-z
更新日期：2018-01-08 00:00:00
