Angiogenic Gene Expression in Down Syndrome Fetal Hearts.


INTRODUCTION:Forty percent of Down syndrome (DS) fetuses have congenital heart defects (CHD). An abnormal angiogenic environment has been described in euploid fetuses with CHD. However, the underlying pathophysiologic pathway that contributes to CHD in DS remains unknown. The objective was to compare the expression of angiogenic factors and chronic hypoxia genes in heart tissue from DS and euploid fetuses with and without CHD. METHODS:The gene expression profile was determined by real-time PCR quantification in heart tissue from 33 fetuses with DS, 23 euploid fetuses with CHD and 23 control fetuses. RESULTS:Angiogenic factors mRNA expression was significantly increased in the DS group compared to the controls (soluble fms-like tyrosine kinase-1, 81%, p = 0.007; vascular endothelial growth factor A, 57%, p = 0.006, and placental growth factor, 32%, p = 0.0227). Significant increases in the transcript level of hypoxia-inducible factor-2α and heme oxygenase 1 were also observed in the DS group compared to the controls. The expression of angiogenic factors was similar in DS fetuses and CHD euploid fetuses with CHD. CONCLUSION:Abnormal angiogenesis was detected in the hearts of DS fetuses with and without CHD. Our results suggest that DS determines an intrinsically angiogenic impairment that may be present in the fetal heart.


Fetal Diagn Ther


Sánchez O,Domínguez C,Ruiz A,Ribera I,Alijotas J,Cabero L,Carreras E,Llurba E




Has Abstract


2016-01-01 00:00:00














  • Risk estimation of intraamniotic infection development after serial amniocentesis.

    abstract::Microbial invasion and growth in amniotic fluid play an important role in infectious perinatal morbidity and mortality. In order to determine the influence of amniocentesis (ACT) on intra-amniotic infection development, we performed a study of 239 complete microbiological examinations of amniotic fluid specimens obtai...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Terzić MM,Plećas DV,Stimec BV,Petković SV

    更新日期:1994-01-01 00:00:00

  • Optimal interval between middle cerebral artery velocity measurements when monitoring pregnancies complicated by red cell alloimmunization.

    abstract:OBJECTIVE:To evaluate the optimal interval between middle cerebral artery (MCA) Doppler measurements when monitoring pregnancies complicated by red cell alloimmunization. METHODS:Thirty-nine fetal blood samplings (FBS) performed on 24 pregnant women with red blood cell alloimmunization followed up using both MCA peak ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Bartha JL,Abdel-Fattah SA,Hunter A,Denbow M,Kyle P,Soothill PW

    更新日期:2006-01-01 00:00:00

  • The changes in angiogenic gene expression in recurrent multiple chorioangiomas.

    abstract:OBJECTIVES:To assess the messenger ribonucleic acid expression in placental tissue of growth factors, cytokines, angiogenic and anti-angiogenic factors in one case of recurrent multiple chorioangiomas. METHODS:Complementary deoxyribonucleic acid array analysis was performed on the affected placentae and on normal plac...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Gallot D,Marceau G,Laurichesse-Delmas H,Vanlieferinghen P,Dechelotte PJ,Lemery D,Sapin V

    更新日期:2007-01-01 00:00:00

  • Neonatal leukemoid reaction and early development of bronchopulmonary dysplasia in a very low-birth-weight infant.

    abstract::The factors controlling the recruitment of inflammatory cells and the activation of the cytokine cascade in low-birth-weight premature infants have been implicated in the sequence of multiorgan inflammatory diseases, including the chronic lung disease of prematurity, bronchopulmonary dysplasia. This article describes ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Zanardo V,Magarotto M,Rosolen A

    更新日期:2001-05-01 00:00:00

  • Ex utero Intrapartum Treatment to Ventricular Pacing: A Novel Delivery Strategy for Complete Atrioventricular Block with Severe Bradycardia.

    abstract::Fetuses with anti-SSA-mediated complete atrioventricular block (CAVB) are at high risk for perinatal death if they present at <20 weeks of gestation and develop ventricular rates of <55 beats per minute (bpm), cardiac dysfunction, or hydrops [Izmirly et al.: Circulation 2011;124:1927-1935; Jaeggi et al.: J Am Coll Car...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Cuneo BF,Mitchell MB,Marwan AI,Green M,von Alvensleben JC,Reynolds R,Crombleholme TM,Galan HL

    更新日期:2017-01-01 00:00:00

  • Sequential Amniotic Fluid Thyroid Hormone Changes Correlate with Goiter Shrinkage following in utero Thyroxine Therapy.

    abstract::Several isolated reports of fetal goiter treatment have shown limited generalizability of approaches and provide no real guidance for optimal timing, dosages, and treatment strategies. Graves' disease accounts for >60% of these cases. Maternal treatments of hyperthyroidism include antithyroid medications such as methi...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Munoz JL,Kessler AA,Felig P,Curtis J,Evans MI

    更新日期:2016-01-01 00:00:00

  • Maternal Anxiety and the Second-Trimester Prenatal Screening: A Prospective Cohort Study.

    abstract:OBJECTIVE:Assessing the effects of maternal anxiety on the markers and results of quadruple screening and on maternal anxiety after receiving positive results. METHODS:This prospective cohort study evaluated 1,595 pregnant women referred for prenatal visits. Maternal state/trait anxiety levels were measured, then quad...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Mousavi S,Hantoushzadeh S,Sheikh M,Shariat M

    更新日期:2015-01-01 00:00:00

  • Bidirectional communication between neural and cardiac cells in human amniotic fluid.

    abstract:OBJECTIVE:To evaluate whether amniotic fluid cells contain cardiomyocyte- and neuron-like cells. STUDY DESIGN:In this experimental study, cells from human amniotic fluid samples were analyzed for mRNA expression of microtubule-associated protein 2 (MAP-2), vimentin and oxytocin (OT) receptor via RT-PCR. Immunocytochem...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Stefanidis K,Loutradis D,Anastasiadou V,Dinopoulou V,Eleni E,Arampatzi E,Lekka K,Mesogitis S,Antsaklis A

    更新日期:2009-01-01 00:00:00

  • Fetal heart disease: severity, associated anomalies and parental decision.

    abstract:OBJECTIVE:This study describes the association between the complexity of congenital cardiac and extracardiac malformations, and the parental decision of pregnancy continuation or termination. METHODS:Congenital heart defects (CHD) was diagnosed by ultrasound in 251 fetuses before the 24th week (23 + 6 weeks) of gestat...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Nell S,Wijngaarde CA,Pistorius LR,Slieker M,ter Heide H,Manten GT,Freund MW

    更新日期:2013-01-01 00:00:00

  • Management of twin anemia-polycythemia sequence using intrauterine blood transfusion for the donor and partial exchange transfusion for the recipient.

    abstract::Twin anemia-polycythemia sequence (TAPS) is a rare condition which may occur either spontaneously in uncomplicated monochorionic twin pregnancies or may develop after laser treatment in twin-twin transfusion syndrome. TAPS is characterized by a large intertwin discordance in hemoglobin levels without discordance in am...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Genova L,Slaghekke F,Klumper FJ,Middeldorp JM,Steggerda SJ,Oepkes D,Lopriore E

    更新日期:2013-01-01 00:00:00

  • Thoraco-omphalopagus conjoined twins detected at as early as 9 weeks of gestation: transvaginal two-dimensional ultrasound, color Doppler and fetoplacental Doppler velocity waveform findings.

    abstract::Here we report a case of conjoined twins that were diagnosed antenatally by routine two-dimensional transvaginal ultrasound examination at as early as the 9th week of gestational age. The fetuses were of the thoraco-omphalopagus type and were sharing the liver, as confirmed by color Doppler. There was a reversed flow ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Basgül A,Kavak ZN,Sezen D,Basgul A,Gokaslan H

    更新日期:2006-01-01 00:00:00

  • Use of an Amnioport to Maintain Amniotic Fluid Volume in Fetuses with Oligohydramnios Secondary to Lower Urinary Tract Obstruction or Fetal Renal Anomalies.

    abstract:OBJECTIVE:We describe a technique to maintain amniotic fluid in fetuses with severe oligo-/anhydramnios secondary to lower urinary tract obstruction or fetal renal disease when urine production is inadequate to maintain a normal amniotic fluid volume (AFV). METHODS:An amnioport was inserted into the amniotic space. Th...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Polzin WJ,Lim FY,Habli M,Van Hook J,Minges M,Jaekle R,Crombleholme TM

    更新日期:2017-01-01 00:00:00

  • Isolated fetal bilateral radial ray reduction associated with valproic acid usage.

    abstract::The authors describe the first case of an isolated bilateral radial ray reduction occurring in a fetus exposed in utero to valproic acid; the diagnosis was made by ultrasound during the second trimester. This case of an isolated radial ray reduction associated with valproic acid use in pregnancy is a reminder for sono...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Langer B,Haddad J,Gasser B,Maubert M,Schlaeder G

    更新日期:1994-05-01 00:00:00

  • Prenatal diagnosis of 'true tail' with cartilage content?

    abstract::A human tail is a rare congenital anomaly with a prominent lesion from the lumbosacrococcygeal region. According to Dao and Netzky human tails are classified into 'true tails' and 'pseudotails'. True tails comprise only mesenchymal tissue (adipose, connective, muscle, nerve tissue, blood vessels, and cutis). They are ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Noack F,Reusche E,Gembruch U

    更新日期:2003-07-01 00:00:00

  • Successful fetal intervention for congenital high airway obstruction syndrome.

    abstract:INTRODUCTION:Complete congenital high airway obstruction syndrome (CHAOS) usually leads to stillbirth or death within minutes of delivery. We describe the management and long-term follow-up of a baby with a prenatally diagnosed airway obstruction. CASE:Because of progressive hydrops fetalis, massive ascites and everte...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Paek BW,Callen PW,Kitterman J,Feldstein VA,Farrell J,Harrison MR,Albanese CT

    更新日期:2002-09-01 00:00:00

  • Pulmonary Vein Flow Impedance: An Early Predictor of Cardiac Dysfunction in Intrauterine Growth Restriction.

    abstract:INTRODUCTION:In intrauterine growth restriction (IUGR), increased uteroplacental vascular impedance contributes to preferential flow to left ventricle (LV), with consequent alteration of its compliance and increased left atrial (LA) pressure. Pulmonary vein pulsatility index (PVPI) reflects the increased impedance to L...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Bravo-Valenzuela NJM,Zielinsky P,Zurita-Peralta J,Nicoloso LH,Piccoli A Jr,Ferreira Van der Sand L,Miranda Sulis N,Carvalho Ritter C

    更新日期:2019-01-01 00:00:00

  • Evaluation of prolonged fetal monitoring with normal and pathologic outcome probabilities determined by artificial neural network.

    abstract:OBJECTIVE:The purpose of this study was to objectively evaluate prolonged fetal heart rate (FHR) monitoring, which has been difficult to do with conventional cardiotocogram (CTG). METHODS:FHR was analyzed by an artificial neural network computer that calculates probabilities of normal, pathologic and suspicious outcom...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Maeda K,Noguchi Y,Matsumoto F

    更新日期:2003-09-01 00:00:00

  • Meconium staining and meconium aspiration syndrome. Is there seasonal variation?

    abstract:OBJECTIVE:To determine whether the incidence of pregnancies complicated by meconium-stained amniotic fluid (MSAF) or meconium aspiration syndrome (MAS) differs with seasonal changes. METHODS:An established perinatal database was used to identify all term (> or = 37 weeks) singleton gestations resulting in a live birth...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Blackwell SC,Carreno CA,Hassan SS,Moldenhauer J,Wolfe HM,Berry SM,Kruger M,Sorokin Y

    更新日期:2001-07-01 00:00:00

  • Pastoral care utilization among women electing pregnancy termination for fetal anomalies.

    abstract:OBJECTIVE:To identify determinants of requesting pastoral care (PC) at the time of pregnancy termination for fetal anomalies. METHODS:PC was provided by a hospital-based chaplain. Data were reviewed for 88 women who elected pregnancy termination. Nominal logistic regression and Kruskal-Wallis and Student t tests were ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Brady TB,Lidums S,Yaron Y,Evans MI,Johnson MP,Kramer RL

    更新日期:1998-03-01 00:00:00

  • First-trimester diagnosis of sirenomelia. A case report.

    abstract::We report a case of sirenomelia diagnosed at 13 gestational weeks. This rare malformation sequence is characterized by fusion and rotation of the lower limbs to various degrees and anorectal atresia, usually associated with absence of bladder and agenesis or dysgenesis of the kidneys. Diagnosis is commonly made later ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审


    authors: Carbillon L,Seince N,Largillière C,Bucourt M,Uzan M

    更新日期:2001-09-01 00:00:00

  • Management of a case of twin-to-twin transfusion syndrome by a combined surgical approach.

    abstract:OBJECTIVE:The management of a case of severe twin-to-twin transfusion syndrome at 24 weeks of gestation is presented, using a combined surgical and medical approach. METHODS:Operative fetoscopy was used to coagulate placental vessels crossing the intertwin membranes. Repeated intrauterine transfusions were used to cor...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Van Peborgh P,Pelletier G,Suarez B,Ville Y

    更新日期:1998-03-01 00:00:00

  • The early amniocentesis study: a randomized clinical trial of early amniocentesis and midtrimester amniocentesis. II. Evaluation of procedure details and neonatal congenital anomalies.

    abstract::The present study provides detailed neonatal and congenital malformation follow-up from 695 women enrolled in a prospective randomized multicenter study comparing the safety and accuracy of early (11-12 weeks of gestation) and midtrimester amniocentesis (15-16 weeks of gestation). No differences were found for total p...

    journal_title:Fetal diagnosis and therapy

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Wilson RD,Johnson J,Windrim R,Dansereau J,Singer J,Winsor EJ,Kalousek D

    更新日期:1997-03-01 00:00:00

  • Liver position is a prenatal predictive factor of prosthetic repair in congenital diaphragmatic hernia.

    abstract:OBJECTIVE:To determine whether any common maternal-fetal variable has prenatal predictive value of prosthetic repair in congenital diaphragmatic hernia. METHODS:This was a 5-year single-center retrospective review of fetal congenital diaphragmatic hernia referrals. Multiple prenatal variables were correlated with the ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Kunisaki SM,Barnewolt CE,Estroff JA,Nemes LP,Jennings RW,Wilson JM,Fauza DO

    更新日期:2008-01-01 00:00:00

  • Prenatal diagnosis of cystic neuroblastoma.

    abstract::Cystic adrenal masses are unusual in the fetus. The most common diagnosis for adrenal cyst is hemorrhage. We report 2 cases of cystic neuroblastoma diagnosed prenatally by ultrasound. In each case, diagnosis was confirmed in the neonatal period first by scintigraphy, then by histology. Differential diagnosis and manag...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Dreyfus M,Neuhart D,Baldauf JJ,Casanova R,Becmeur F,Ritter J

    更新日期:1994-07-01 00:00:00

  • Dysthymic reactions of women undergoing chorionic villus sampling for prenatal diagnosis of hemoglobinopathies or karyotyping.

    abstract:OBJECTIVES:The aim of the study was to investigate the levels of anxiety and depression, as well as liability to depression, of women undergoing chorionic villus sampling (CVS) due to the risk of giving birth to a child suffering from hemoglobinopathy, or trisomy. METHODS:The study population consisted of 309 women wh...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Lykeridou K,Daskalakis G,Papadatou D,Vaslamatzis G,Dafni O,Antsaklis A

    更新日期:2004-03-01 00:00:00

  • Fetal parvovirus B19 infection and meconium peritonitis.

    abstract::A 33-year-old primigravida at 26 weeks gestation presented with fetal hydrops and fetal anemia following prior parvovirus B19 infection. The fetus required two intrauterine transfusions of packed red cells. At 35 weeks gestation, a cesarean section was performed for obstetric reasons. As a consequence of a prenatal bo...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Schild RL,Plath H,Thomas P,Schulte-Wissermann H,Eis-Hübinger AM,Hansmann M

    更新日期:1998-01-01 00:00:00

  • Prenatal diagnosis for Schmid metaphyseal chondrodysplasia in twins.

    abstract::We report prenatal diagnostic studies for metaphyseal chondrodysplasia of the Schmid type. Identification of a specific COL10A1 gene mutation in an affected father allowed prenatal diagnosis by chorionic villus sampling in a twin pregnancy. Neither of the nonidentical twins received the abnormal COL10A1 gene from thei...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Milunsky J,Maher T,Lebo R,Milunsky A

    更新日期:1998-05-01 00:00:00

  • The Aortic Isthmus: A Significant yet Underexplored Watershed of the Fetal Circulation.

    abstract::The aortic isthmus (AoI) is a unique fetal watershed with a waveform reflecting its complex haemodynamic physiology. The systolic component represents left and right ventricular systolic ejection, and the diastolic component represents comparative downstream vascular impedance between the brachiocephalic and subdiaphr...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审


    authors: Tynan D,Alphonse J,Henry A,Welsh AW

    更新日期:2016-01-01 00:00:00

  • Direct fetal intravenous immunoglobulin infusion as an adjunct to intrauterine fetal blood transfusion in rhesus-allommunized pregnancies: a pilot study.

    abstract:OBJECTIVES:To study the usefulness of direct fetal intravenous immunoglobulin (IVIG) infusion along with intrauterine transfusion (IUT) in the management of severe fetal anemia in rhesus (Rh) alloimmunized pregnancies. METHODS:Thirty-four consecutive Rh-isoimmunized pregnant women who required serial IUTs received eit...

    journal_title:Fetal diagnosis and therapy

    pub_type: 临床试验,杂志文章


    authors: Deka D,Sharma KA,Dadhwal V,Singh A,Kumar G,Vanamail P

    更新日期:2013-01-01 00:00:00

  • Efficiency of ultrasound and biochemical markers for Down's syndrome risk screening. A prospective study.

    abstract:OBJECTIVE:To evaluate the sequential combination of ultrasound screening for fetal aneuploidy at 11-14 weeks with maternal biochemistry at 12-14 and 15-18 weeks of gestation. METHODS:A prospective study including 1,656 women, with a singleton pregnancy booked before 13 weeks of gestation. Nuchal translucency (NT) thic...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Benattar C,Audibert F,Taieb J,Ville Y,Roberto A,Lindenbaum A,Frydman R

    更新日期:1999-03-01 00:00:00