Abstract:
BACKGROUND/AIMS:Gastrointestinal symptoms and hypothalamus-pituitary-adrenal (HPA) axis dysfunction are frequently observed in patients with major depression. The primary aim of the study was to investigate the relationship between HPA-axis function and self-perceived functional gastrointestinal symptoms in major depression. METHODS:Patients with major depression (n = 73) and controls representative of the general population (n = 146) underwent a weight adjusted very low dose dexamethasone suppression test (DST). Patients and controls completed the gastrointestinal symptom rating scale-iritable bowel syndrome (GSRS-IBS) and the hospital anxiety depression scale. Medical records of the patients were screened over a ten year period for functional gastrointestinal disorder and pain conditions. RESULTS:Patients with high GSRS-IBS scores (above median) exhibited HPA-axis hypersuppression more often than controls (defined by the lowest 10% cutoff of the post-DST cortisol values among controls, adjusted OR 7.25, CI 1.97-26.7) whereas patients with low GSRS-IBS scores did not differ from controls concerning their post-DST cortisol values. Patients who had consulted primary care for functional gastrointestinal disorder (P = 0.039), lumbago (P = 0.006) and chronic multifocal pain (P = 0.057) also exhibited an increased frequency of hypersuppression. CONCLUSIONS:HPA-axis hypersuppression is associated with functional gastrointestinal symptoms in patients with major depression.
journal_name
J Neurogastroenterol Motiljournal_title
Journal of neurogastroenterology and motilityauthors
Karling P,Wikgren M,Adolfsson R,Norrback KFdoi
10.5056/jnm15064subject
Has Abstractpub_date
2016-04-30 00:00:00pages
292-303issue
2eissn
2093-0879issn
2093-0887pii
jnm15064journal_volume
22pub_type
杂志文章abstract:BACKGROUND/AIMS:Antispasmodics including otilonium bromide (OB) are recommended to treat irritable bowel syndrome (IBS). However, reports about OB experience in Asia is sparse. The purpose of present study was to provide the efficacy of OB in treating Asian IBS patients. METHODS:Overall, 117 IBS patients meeting Rome ...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2011.17.4.402
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND/AIMS:Rome criteria classifying functional gastrointestinal disorder (FGID) were updated. The aims of this study were to assess the spectra of FGID and to evaluate the applicability of Rome III criteria in Korea. METHODS:New patients who visited 2 primary clinics and 2 tertiary care hospitals were consecutiv...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2011.17.3.279
更新日期:2011-07-01 00:00:00
abstract::Cyclic vomiting syndrome (CVS) is a disorder characterized by recurrent episodes of incapacitating nausea and vomiting interspersed with symptom free periods. Common triggers of cyclic vomiting include noxious stress, excitement, fatigue and menstrual period. Here, we report a case of cyclic vomiting syndrome in adult...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2010.16.1.77
更新日期:2010-01-01 00:00:00
abstract::In predisposed individuals with long standing gastroesophageal reflux disease (GERD), esophageal squamous mucosa can transform into columnar mucosa with intestinal metaplasia, commonly called Barrett's esophagus (BE). Barrett's mucosa can develop dysplasia, which can be a precursor for esophageal adenocarcinoma (EAC)....
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm18156
更新日期:2019-04-30 00:00:00
abstract:BACKGROUND/AIMS:Irritable bowel syndrome (IBS) is a widespread chronic health condition which is significantly more prevalent in women. We conducted a gender difference analysis by comparing findings of men and women to determine whether any significant differences exist or not. METHODS:This single-center study was co...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2012.18.1.70
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:To draw a normative database of laryngopharynx pH profile in Chinese subjects. METHODS:Normal volunteers were recruited from "www.Ganji.com" and People's hospital between May 2008 and December 2009. The Restech pH Probes were calibrated in pH 7 and pH 4 buffer solutions according to the manufacturer's ...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm13138
更新日期:2014-07-31 00:00:00
abstract:Background/Aims:Probiotics are expected to modify the composition of gut microbiota. We aimed to investigate the changes in the composition and diversity of gut microbiota by the administration of probiotics in healthy individuals. Methods:Twelve healthy volunteers with age range of 30-42 years provided baseline fecal...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm17140
更新日期:2018-07-30 00:00:00
abstract:BACKGROUND/AIMS:Rats with a spontaneous null mutation in endothelin receptor type B or Ednrb (sl/sl; spotting lethal) lack enteric neurons in the distal bowel and usually die within the first week after birth. This early postnatal lethality limits their use for examining the potential of cell therapy to treat Hirschspr...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm15079
更新日期:2015-10-01 00:00:00
abstract:Background/Aims:Recent studies suggest that air pollution may play a role in gastrointestinal disorders. However, the effect of long-term exposure to air pollution on childhood irritable bowel syndrome (IBS) is unclear. Hence, we conducted a nationwide cohort study to investigate the association between long-term air p...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm18135
更新日期:2019-04-30 00:00:00
abstract:Background/Aims:Interstitial cells play important roles in gastrointestinal (GI) neuro-smooth muscle transmission. The underlying mechanisms of colonic dysmotility have not been well illustrated. We established a partial colon obstruction (PCO) mouse model to investigate the changes of interstitial cells and the correl...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm19136
更新日期:2019-10-30 00:00:00
abstract:Background/Aims:Self-reported lactose intolerance (LI) is frequent in patients with functional bowel disorders (FBD) that could be interpreted as irritable bowel syndrome (IBS). The present study aims to characterize the responses of FBD patients without small intestinal bacterial overgrowth (SIBO), and LI, in terms of...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm20094
更新日期:2020-12-28 00:00:00
abstract:Background/Aims:The prevalence of eosinophilic esophagitis (EoE) is reportedly increasing in Western countries. However, its prevalence in Korea remains unknown. We investigated the diagnostic trends and clinical characteristics of EoE in Korea. Methods:Using an endoscopic database maintained at a tertiary care center...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm17047
更新日期:2018-04-30 00:00:00
abstract:BACKGROUND/AIMS:The marketing of newer agents for treatment of constipation and irritable bowel syndrome with constipation (IBS-C) emphasize improvements in abdominal pain. However, it is not clear whether this observation reflects a unique visceral analgesic effect of these agents or is a general feature of effective ...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm15171
更新日期:2016-01-31 00:00:00
abstract:BACKGROUND/AIMS:Despite numerous studies on the relation of genetic polymorphisms with irritable bowel syndrome (IBS), the results still remain inconclusive. The aim of this study was to assess the possible association between SLC6A4 serotonin transporter gene linked polymorphic region (5-HTTLPR), ADRA2A -1291C>G, GNB3...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm14020
更新日期:2014-07-31 00:00:00
abstract::Radiofrequency catheter ablation (RFCA) is a potentially curative method for treatment of highly symptomatic and drug-refractory atrial fibrillation (AF). However, this technique can provoke esophageal and nerve lesion, due to thermal injury. To our knowledge, there have been no reported cases of a newly described mot...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm15034
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND/AIMS:Recent studies reveal that acute gastroenteritis can precipitate irritable bowel syndrome (IBS) symptoms leading to the concept of post-infectious IBS. However, the overall contribution of gastroenteritis to the total IBS prevalence is unknown. In this exercise we try to estimate the contribution of gas...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2012.18.2.200
更新日期:2012-04-01 00:00:00
abstract::Author's name was mis-typed. The name "Oya B Sezer" in the original article should have been written as "Oya Balcı Sezer." ...
journal_title:Journal of neurogastroenterology and motility
pub_type: 已发布勘误
doi:10.5056/jnm25012
更新日期:2019-01-31 00:00:00
abstract:BACKGROUND/AIMS:Approximately one-third of non-erosive reflux disease (NERD) patients are refractory to proton pump inhibitors (PPI) and face a therapeutic challenge. Therefore, it is important to differentiate between pathological and non-pathological reflux utilizing multichannel intraluminal impedance-pH (MII-pH) to...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm14038
更新日期:2014-10-30 00:00:00
abstract:BACKGROUND/AIMS:Irritable bowel syndrome (IBS) is one of the most frequently observed disorders by primary care and practitioners. The aim of this study was to estimate the prevalence of IBS using the Rome II and III criteria in the general Korean population and also to compare sociodemographic differences between subj...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2010.16.2.186
更新日期:2010-04-01 00:00:00
abstract:Background/Aims:Since the use of dexlansoprazole in Asian subjects with gastroesophageal reflux disease (GERD) has not been adequately characterized, this study was conducted to evaluate the efficacy and safety of dexlansoprazole modified-release in Asian subjects with non-erosive reflux disease (NERD) and erosive esop...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm19031
更新日期:2020-01-30 00:00:00
abstract:BACKGROUND/AIMS:Gastroparesis-like syndrome (GLS) is defined as gastroparesis-like symptoms with normal gastric scintigraphy. While the efficacy of gastric electrical stimulation (GES) in gastroparesis is well known, the utility of GES in GLS is largely unknown. Our aim was to clarify the role of GES in GLS. We implant...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm15046
更新日期:2015-10-01 00:00:00
abstract:Background/Aims:High-resolution manometry (HRM) has broadened the awareness of minor esophageal peristaltic disorders. However, the treatments for these minor disorders are limited and the role of prokinetics has been controversial. This study evaluates the effect of mosapride in patients with minor peristaltic disorde...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm19062
更新日期:2020-04-30 00:00:00
abstract:BACKGROUND/AIMS:Researches on the potential risk factors for the development of erosive esophagitis have been conducted extensively, however, the results are conflicting. The aim of this multicenter study was to identify the prevalence rate and risk factors of erosive esophagitis and their interactions with residency s...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2013.19.1.70
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:In isolated guinea-pig colon, we investigated regional differences in peristalsis evoked by intrinsic electrical nerve stimulation. METHODS:Four colonic segments from mid and distal colon of Hartley guinea pigs, were mounted horizontally in an organ bath. Measurement of pellet propulsion time, intralum...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2013.19.2.192
更新日期:2013-04-01 00:00:00
abstract:Background/Aims:Current evidence suggests the presence of motility or functional abnormalities in one area of the gastrointestinal tract increases the likelihood of abnormalities in others. However, the relationship of gastroparesis to chronic constipation (slow transit constipation and dyssynergic defecation) has been...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm18206
更新日期:2019-04-30 00:00:00
abstract:BACKGROUND/AIMS:Proton pump inhibitors (PPIs) which are the most effective agents for the treatment of gastroesophageal reflux disease (GERD), have been known to delay gastric emptying. Mosapride has been used as prokinetics by accelerating gastric emptying. We evaluated the efficacy of mosapride to prevent PPI-induced...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2013.19.4.495
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND/AIMS:Solifenacin, a muscarinic type 3 receptor antagonist, is used to treat overactive bladder in adults. The aim of this study is to examine the efficacy of solifenacin on the symptomatic relief of diarrhea predominant irritable bowel syndrome (IBS-D). METHODS:A total of 20 patients with IBS-D were enrolle...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2012.18.3.317
更新日期:2012-07-01 00:00:00
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm16097
更新日期:2017-04-30 00:00:00
abstract::Irritable bowel syndrome (IBS) has been one of the commonly presented gastrointestinal disorders. It is of interest how commonly it presents in the society. Western studies indicated that most population-based IBS prevalences range 10%-15%. It is believed that IBS is prevalent in both East and West countries without a...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2010.16.4.389
更新日期:2010-10-01 00:00:00
abstract::Assessment of transit through the gastrointestinal tract provides useful information regarding gut physiology and patho-physiology. Although several methods are available, each has distinct advantages and limitations. Recently, an ingestible wire-less motility capsule (WMC), similar to capsule video endoscopy, has bec...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2014.20.2.265
更新日期:2014-04-30 00:00:00