Abstract:
:We are concerned with statistical inference for 2 × C × K contingency tables in the context of genetic case-control association studies. Multivariate methods based on asymptotic Gaussianity of vectors of test statistics require information about the asymptotic correlation structure among these test statistics under the global null hypothesis. In the case of C=2, we show that for a wide variety of test statistics this asymptotic correlation structure is given by the standardized linkage disequilibrium matrix of the K loci under investigation. Three popular choices of test statistics are discussed for illustration. In the case of C=3, the standardized composite linkage disequilibrium matrix is the limiting correlation matrix of the K locus-specific Cochran-Armitage trend test statistics.
journal_name
Stat Appl Genet Mol Biolauthors
Dickhaus T,Stange J,Demirhan Hdoi
10.1515/sagmb-2015-0024subject
Has Abstractpub_date
2015-11-01 00:00:00pages
497-505issue
5eissn
2194-6302issn
1544-6115pii
/j/sagmb.ahead-of-print/sagmb-2015-0024/sagmb-2015journal_volume
14pub_type
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