T cells, teeth and tissue destruction - what do T cells do in periodontal disease?


:The microbial plaque biofilm resides adjacent to the tissue-destructive inflammatory infiltrate in periodontitis. Although not sufficient, this biofilm is necessary for this inflammatory response. Patients with periodontitis generate antibodies specific for bacteria in the biofilm - although the role of these antibodies is not clear, there is, undoubtedly, an adaptive immune response in periodontitis. T lymphocytes are central to adaptive immunity, and provide help for B cells to generate specific antibodies. T-cell receptor recognition of peptide antigen in the context of major histocompatibility complex can result in T-cell activation. The activation and differentiation of the T-cell can take many forms, and hence numerous types of T cells have been described. The role of adaptive immune responses, and the T-cell component thereof, in periodontitis remains relatively poorly defined. This review aims to broadly summarize findings about T cells and their role in periodontitis, focusing primarily on studies of human disease with a short discussion of some animal studies.


Mol Oral Microbiol


Campbell L,Millhouse E,Malcolm J,Culshaw S




Has Abstract


2016-12-01 00:00:00












  • The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization.

    abstract::Porphyromonas gingivalis is a bacterial species that causes destruction of periodontal tissues. Additionally, previous evidence indicates that GroEL from P. gingivalis may possess biological activities involved in systemic inflammation, especially inflammation involved in the progression of periodontal diseases. The l...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Lin FY,Huang CY,Lu HY,Shih CM,Tsao NW,Shyue SK,Lin CY,Chang YJ,Tsai CS,Lin YW,Lin SJ

    更新日期:2015-06-01 00:00:00

  • Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways.

    abstract::A hallmark of infection with the gram-negative pathogen Porphyromonas gingivalis is the induction of a chronic inflammatory response. P. gingivalis induces a local chronic inflammatory response that results in oral inflammatory bone destruction, which manifests as periodontal disease. In addition to chronic inflammati...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章,评审


    authors: Hayashi C,Gudino CV,Gibson FC 3rd,Genco CA

    更新日期:2010-10-01 00:00:00

  • DNA from Porphyromonas gingivalis and Tannerella forsythia induce cytokine production in human monocytic cell lines.

    abstract::Toll-like receptor 9 (TLR9) expression is increased in periodontally diseased tissues compared with healthy sites indicating a possible role of TLR9 and its ligand, bacterial DNA (bDNA), in periodontal disease pathology. Here, we determine the immunostimulatory effects of periodontal bDNA in human monocytic cells (THP...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Sahingur SE,Xia XJ,Alamgir S,Honma K,Sharma A,Schenkein HA

    更新日期:2010-04-01 00:00:00

  • Activation of NLRP3 inflammasome in macrophages by mycoplasmal lipoproteins and lipopeptides.

    abstract::The NLRP3 inflammasome, an intracellular sensor consisting of the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3), the adaptor protein apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC), and procaspase-1, plays critical roles in host ...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Saeki A,Sugiyama M,Hasebe A,Suzuki T,Shibata K

    更新日期:2018-08-01 00:00:00

  • Role of extracytoplasmic function sigma factor PG1660 (RpoE) in the oxidative stress resistance regulatory network of Porphyromonas gingivalis.

    abstract::In Porphyromonas gingivalis, the protein PG1660, composed of 174 amino acids, is annotated as an extracytoplasmic function (ECF) sigma factor (RpoE homologue-σ24). Because PG1660 can modulate several virulence factors and responds to environmental signals in P. gingivalis, its genetic properties were evaluated. PG1660...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Dou Y,Rutanhira H,Chen X,Mishra A,Wang C,Fletcher HM

    更新日期:2018-02-01 00:00:00

  • A pathogenic trace of Tannerella forsythia - shedding of soluble fully active tumor necrosis factor α from the macrophage surface by karilysin.

    abstract::Tannerella forsythia is implicated as a pathogen causing chronic and aggressive periodontitis. However, its virulence factors, including numerous putative proteases, are mostly uncharacterized. Karilysin is a newly described matrix metalloprotease-like enzyme of T. forsythia. Since pathogen-derived proteases may affec...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Bryzek D,Ksiazek M,Bielecka E,Karim AY,Potempa B,Staniec D,Koziel J,Potempa J

    更新日期:2014-12-01 00:00:00

  • Lactobacillus rhamnosus LRB mediated inhibition of oral streptococci.

    abstract::Lactobacillus rhamnosus is a lactic acid bacterium with a diverse ecological habitat. We recently isolated a L. rhamnosus strain (LRB) from a healthy baby-tooth that had naturally fallen out. We determined the whole genome sequence of LRB and found that the isolate is closely genetically related to an intestinal isola...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Biswas S,Turner L,Biswas I

    更新日期:2018-10-01 00:00:00

  • Impact of pneumococcal microbial surface components recognizing adhesive matrix molecules on colonization.

    abstract::Microorganisms have evolved elaborate strategies to adhere to host cells and to evade the host complement and immune attack, ensuring survival in various host niches and dissemination into sterile parts of the human body. Streptococcus pneumoniae (the pneumococcus) is not only a commensal of the human respiratory trac...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章,评审


    authors: Voss S,Gámez G,Hammerschmidt S

    更新日期:2012-08-01 00:00:00

  • Predation of oral pathogens by Bdellovibrio bacteriovorus 109J.

    abstract::Periodontal diseases are multifactorial infections elicited by a complex of primarily gram-negative bacteria that interact with host tissues and lead to the destruction of the periodontal structures. Bdellovibrio bacteriovorus is a gram-negative bacterium that preys upon other gram-negative bacteria. It was previously...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Dashiff A,Kadouri DE

    更新日期:2011-02-01 00:00:00

  • Association of CiaRH with resistance of Streptococcus mutans to antimicrobial peptides in biofilms.

    abstract::Streptococcus mutans is a cariogenic pathogen in humans. To persist in the oral cavity, S. mutans is resistant against several antibacterial factors derived from the host. In this study, we investigated the mechanism of resistance to cationic antimicrobial peptides (AMPs), which are innate immune factors in humans. Be...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Mazda Y,Kawada-Matsuo M,Kanbara K,Oogai Y,Shibata Y,Yamashita Y,Miyawaki S,Komatsuzawa H

    更新日期:2012-04-01 00:00:00

  • Inhibition of Porphyromonas gingivalis-induced periodontal bone loss by CXCR4 antagonist treatment.

    abstract::Microbial pathogens have evolved mechanisms to proactively manipulate innate immunity, thereby improving their fitness in mammalian hosts. We have previously shown that Porphyromonas gingivalis exploits CXC-chemokine receptor-4 (CXCR4) to instigate a subversive crosstalk with Toll-like receptor 2 that inhibits leukocy...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: McIntosh ML,Hajishengallis G

    更新日期:2012-12-01 00:00:00

  • Cultivation of Peptidiphaga gingivicola from subgingival plaque: The first representative of a novel genus of Actinomycetaceae.

    abstract::A novel bacterium was isolated from the subgingival plaque of a patient with periodontal disease. Bacterial strain BA112T is a facultative Gram-positive coccus. It metabolizes alanine, arginine, glycine, histidine, leucine, proline, serine and tyrosine, but does not appear to use carbohydrates. Urease, esculin, indole...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Beall CJ,Mokrzan EM,Griffen AL,Leys EJ

    更新日期:2018-02-01 00:00:00

  • Characterization of a stress tolerance-defective mutant of Lactobacillus rhamnosus LRB.

    abstract::Lactobacillus rhamnosus is a lactic acid bacterium that survives diverse ecological niches, including the human oral cavity and gastrointestinal tract. L. rhamnosus is an acidogenic bacterium that produces copious amounts of lactic acid. The organism is also considered as aciduric, since it can survive prolonged expos...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Biswas S,Keightley A,Biswas I

    更新日期:2019-08-01 00:00:00

  • Response of MG63 osteoblasts on bacterial challenge is dependent on the state of differentiation.

    abstract::The present in vitro study examines molecular processes that are relevant during bone homeostasis after Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis infection with a focus on the differentiation level of osteoblasts. Regenerative processes are often hindered by the recurrence of bacterial infecti...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Hoppe T,Göser V,Kraus D,Probstmeier R,Frentzen M,Wenghoefer M,Jepsen S,Winter J

    更新日期:2018-04-01 00:00:00

  • ArcR modulates biofilm formation in the dental plaque colonizer Streptococcus gordonii.

    abstract::Biofilm formation and cell-cell sensing by the pioneer dental plaque colonizer Streptococcus gordonii are dependent upon arginine. This study aimed to identify genetic factors linking arginine-dependent responses and biofilm formation in S. gordonii. Isogenic mutants disrupted in genes required for the biosynthesis or...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Robinson JC,Rostami N,Casement J,Vollmer W,Rickard AH,Jakubovics NS

    更新日期:2018-04-01 00:00:00

  • In vivo and ex vivo actions of a novel P. gingivalis inhibitor on multi-species biofilm, inflammatory response, and periodontal bone loss.

    abstract::Chronic periodontitis is one of the most common infectious inflammatory diseases worldwide. Current therapeutic options for the disease are only partially and temporarily successful due to periodontal re-emergence of pathogens such as Porphyromonas gingivalis, a keystone bacterium in the oral microbial communities, wh...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Ho MH,Hasturk H,Young DF,Xie H

    更新日期:2020-10-01 00:00:00

  • Periodontal pathogens and clinical parameters in chronic periodontitis.

    abstract::The use of next generation sequencing and bioinformatics has revealed the complexity and richness of the human oral microbiota. While some species are well known for their periodontal pathogenicity, the molecular-based approaches for bacterial identification have raised awareness about new putative periodontal pathoge...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Boyer E,Martin B,Le Gall-David S,Fong SB,Deugnier Y,Bonnaure-Mallet M,Meuric V

    更新日期:2020-01-01 00:00:00

  • Serotype b of Aggregatibacter actinomycetemcomitans increases osteoclast and memory T-lymphocyte activation.

    abstract::During periodontitis, alveolar bone resorption is associated with activation of T helper type 17 (Th17) lymphocytes and receptor activator of nuclear factor-κB ligand (RANKL) -induced osteoclasts. We previously reported that serotype b of Aggregatibacter actinomycetemcomitans has a higher capacity to trigger Th17-type...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Melgar-Rodríguez S,Díaz-Zúñiga J,Alvarez C,Rojas L,Monasterio G,Carvajal P,Escobar A,Sanz M,Vernal R

    更新日期:2016-04-01 00:00:00

  • Molecular characterization of Treponema denticola infection-induced bone and soft tissue transcriptional profiles.

    abstract::Treponema denticola is associated with subgingival biofilms in adult periodontitis and with acute necrotizing ulcerative gingivitis. However, the molecular mechanisms by which T. denticola impacts periodontal inflammation and alveolar bone resorption remain unclear. Here, we examined changes in the host transcriptiona...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Bakthavatchalu V,Meka A,Sathishkumar S,Lopez MC,Verma RK,Wallet SM,Bhattacharyya I,Boyce BF,Mans JJ,Lamont RJ,Baker HV,Ebersole JL,Kesavalu L

    更新日期:2010-08-01 00:00:00

  • Filifactor alocis collagenase can modulate apoptosis of normal oral keratinocytes.

    abstract::To successfully colonize host cells, pathogenic bacteria must circumvent the host's structural barrier such as the collagen-rich extracellular matrix (ECM), as a preliminary step to invasion and colonization of the periodontal tissue. Filifactor alocis possesses a putative Peptidase U32 family protein (HMPREF0389_0050...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Chioma O,Aruni AW,Milford TA,Fletcher HM

    更新日期:2017-04-01 00:00:00

  • Looking in the Porphyromonas gingivalis cabinet of curiosities: the microbium, the host and cancer association.

    abstract::The past decades of biomedical research have yielded massive evidence for the contribution of the microbiome in the development of a variety of chronic human diseases. There is emerging evidence that Porphyromonas gingivalis, a well-adapted opportunistic pathogen of the oral mucosa and prominent constituent of oral bi...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章,评审


    authors: Atanasova KR,Yilmaz O

    更新日期:2014-04-01 00:00:00

  • Desulfovibrio spp. survive within KB cells and modulate inflammatory responses.

    abstract::Desulfovibrio are sulfate-reducing anaerobic gram-negative rods that have been proposed as potential periodontopathogens. We investigated the capacity of Desulfovibrio to invade epithelial cells and induce cytokine secretion from these cells. Desulfovibrio strains were co-cultured with KB cells and counts of intracell...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Bisson-Boutelliez C,Massin F,Dumas D,Miller N,Lozniewski A

    更新日期:2010-06-01 00:00:00

  • Analysis of the complement sensitivity of oral treponemes and the potential influence of FH binding, FH cleavage and dentilisin activity on the pathogenesis of periodontal disease.

    abstract::Treponema denticola, a periopathogen, evades complement-mediated killing by binding the negative complement regulatory protein factor H (FH) to its surface via the FhbB protein. Paradoxically, bound FH is cleaved by T. denticola's dentilisin protease, a process hypothesized to trigger localized dysregulation of comple...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Miller DP,McDowell JV,Bell JK,Goetting-Minesky MP,Fenno JC,Marconi RT

    更新日期:2014-10-01 00:00:00

  • The road less traveled - defining molecular commensalism with Streptococcus sanguinis.

    abstract::The commensal oral microbial flora has evolved with the human host to support colonization of the various intraoral sites without triggering a significant immune response. In exchange, the commensal microbes provide critical protection against invading pathogens. The intrinsic ability of the oral flora to create a sym...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章,评审


    authors: Kreth J,Giacaman RA,Raghavan R,Merritt J

    更新日期:2017-06-01 00:00:00

  • Talk of the town: interspecies communication in oral biofilms.

    abstract::Mature dental biofilms consist of towering microcolonies in which the resident bacterial cells interact with one another and exchange messages in the form of signalling molecules and metabolites. These structures have been compared with the bustling office blocks and apartment buildings of busy cities. Social and comm...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章,评审


    authors: Jakubovics NS

    更新日期:2010-02-01 00:00:00

  • Peptidylarginine deiminase from Porphyromonas gingivalis contributes to infection of gingival fibroblasts and induction of prostaglandin E2 -signaling pathway.

    abstract::Porphyromonas gingivalis (P. gingivalis) expres-ses the enzyme peptidylarginine deiminase (PPAD), which has a strong preference for C-terminal arginines. Due to the combined activity of PPAD and Arg-specific gingipains, P. gingivalis on the cell surface is highly citrullinated. To investigate the contribution of PPAD ...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Gawron K,Bereta G,Nowakowska Z,Lazarz-Bartyzel K,Lazarz M,Szmigielski B,Mizgalska D,Buda A,Koziel J,Oruba Z,Chomyszyn-Gajewska M,Potempa J

    更新日期:2014-12-01 00:00:00

  • Iron- and hemin-dependent gene expression of Porphyromonas gingivalis.

    abstract::Although iron under anaerobic conditions is more accessible and highly reactive because of its reduced form, iron-dependent regulation is not well known in anaerobic bacteria. Here, we investigated iron- and hemin-dependent gene regulation in Porphyromonas gingivalis, an established periodontopathogen that primarily i...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Anaya-Bergman C,Rosato A,Lewis JP

    更新日期:2015-02-01 00:00:00

  • Genetic basis of coaggregation receptor polysaccharide biosynthesis in Streptococcus sanguinis and related species.

    abstract::Interbacterial adhesion between streptococci and actinomyces promotes early dental plaque biofilm development. Recognition of coaggregation receptor polysaccharides (RPS) on strains of Streptococcus sanguinis, Streptococcus gordonii and Streptococcus oralis by Actinomyces spp. type 2 fimbriae is the principal mechanis...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Yang J,Yoshida Y,Cisar JO

    更新日期:2014-02-01 00:00:00

  • Micro-management: curbing chronic wound infection.

    abstract::Chronic wounds, including pressure ulcers, foot ulcers, and venous leg ulcers, have a detrimental impact on the health and well-being of an estimated 2% of people in the UK. Chronic wounds are normally colonized by bacteria and in some instances bacterial load increases sufficiently for infection to ensue. Once a chro...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章,评审


    authors: Withycombe C,Purdy KJ,Maddocks SE

    更新日期:2017-08-01 00:00:00

  • Benzamidine derivatives inhibit the virulence of Porphyromonas gingivalis.

    abstract::We have previously shown that benzamidine-type compounds can inhibit the activity of arginine-specific cysteine proteinases (gingipains HRgpA and RgpB); well-known virulence factors of Porphyromonas gingivalis. They also hinder in vitro growth of this important periodontopathogenic bacterium. Apparently growth arrest ...

    journal_title:Molecular oral microbiology

    pub_type: 杂志文章


    authors: Fröhlich E,Kantyka T,Plaza K,Schmidt KH,Pfister W,Potempa J,Eick S

    更新日期:2013-06-01 00:00:00