Family Access to a Dentist Study (FADS): A multi-center randomized controlled trial.


INTRODUCTION:Many low-income parent/caregivers do not understand the importance of cavity-free primary (baby) teeth and the chronic nature of dental caries (tooth decay). As a consequence, dental preventive and treatment utilization is low even when children are screened in schools and referred for care. This study aims to test a referral letter and Dental Information Guide (DIG) designed using the Common-Sense Model of Self-Regulation (CSM) framework to improve caregivers' illness perception of dental caries and increase utilization of care by children with restorative dental needs. METHODS:A multi-site randomized controlled trial with caregivers of Kindergarten to 4th grade children in urban Ohio and rural Washington State will compare five arms: (1) CSM referral letter alone; (2) CSM referral letter+DIG; (3) reduced CSM referral letter alone; (4) reduced CSM referral letter+DIG; and (5) standard (control) referral. At baseline, children will be screened at school to determine restorative dental needs. If in need of treatment, caregivers will be randomized to study arms and an intervention packet will be sent home. The primary outcome will be dental care based on a change in oral health status by clinical examination 7 months post-screening (ICDAS sealant codes 1 and 2; restoration codes 3-8; extraction). Enrollment commenced summer 2015 with results in summer 2016. CONCLUSION:This study uses the CSM framework to develop and test behavioral interventions to increase dental utilization among low-income caregivers. If effective this simple intervention has broad applicability in clinical and community-based settings.


Contemp Clin Trials


Nelson S,Riedy C,Albert JM,Lee W,Slusar MB,Curtan S,Ferretti G,Cunha-Cruz J,Milgrom P




Has Abstract


2015-11-01 00:00:00




Pt B










  • Recombinant human hepatocyte growth factor for liver failure.

    abstract::The purpose of this paper is to evaluate the efficacy and safety of recombinant human hepatocyte growth factor (rh-HGF) for liver failure (LF) using meta-analysis of data from the literature involving available randomized controlled trials of rh-HGF plus comprehensive therapy (CT) compared with that of CT alone (Thera...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,meta分析


    authors: Cui YL,Meng MB,Tang H,Zheng MH,Wang YB,Han HX,Lei XZ

    更新日期:2008-09-01 00:00:00

  • The safety of tai chi: A meta-analysis of adverse events in randomized controlled trials.

    abstract:OBJECTIVES:To review current publications to examine safety of tai chi (TC). DESIGN:Cochrane Library, EBSCO host and MEDLINE/PubMed were searched for randomized controlled trials (RCTs) including TC as the core intervention and reporting adverse events (AEs). Data were extracted considering active vs. inactive control...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,meta分析


    authors: Cui H,Wang Q,Pedersen M,Wang Q,Lv S,James D,Larkey L

    更新日期:2019-07-01 00:00:00

  • Neurodevelopment of children exposed to anesthesia: design of the Mayo Anesthesia Safety in Kids (MASK) study.

    abstract::There is increasing evidence that exposure of developing brains in animals, including nonhuman primates, to commonly-utilized anesthetic agents may cause adverse effects on cognition and behavior. In this paper, we summarize our methodology for a population-based, propensity-matched study to evaluate possible anesthes...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章


    authors: Gleich SJ,Flick R,Hu D,Zaccariello MJ,Colligan RC,Katusic SK,Schroeder DR,Hanson A,Buenvenida S,Wilder RT,Sprung J,Voigt RG,Paule MG,Chelonis JJ,Warner DO

    更新日期:2015-03-01 00:00:00

  • The blind leading the blind: use and misuse of blinding in randomized controlled trials.

    abstract::The use of blinding strengthens the credibility of randomized controlled trials (RCTs) by minimizing bias. However, there is confusion surrounding the definition of blinding as well as the terms single, double, and triple blind. It has been suggested that these terms should be discontinued due to their broad misinterp...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章


    authors: Miller LE,Stewart ME

    更新日期:2011-03-01 00:00:00

  • Comparative study on the pregnancy outcomes of in vitro fertilization-embryo transfer between long-acting gonadotropin-releasing hormone agonist combined with transvaginal ultrasound-guided cyst aspiration and long-acting gonadotropin-releasing hormone ag

    abstract:OBJECTIVE:To retrospectively analyze the effects of long-acting gonadotropin-releasing hormone agonist (GnRH-a) combined with transvaginal ultrasound-guided cyst aspiration on the pregnancy outcomes of in vitro fertilization-embryo transfer (IVF-ET) in the infertile patients with ovarian endometriosis. METHODS:The 134...

    journal_title:Contemporary clinical trials

    pub_type: 临床试验,杂志文章


    authors: Guo YH,Lu N,Zhang Y,Su YC,Wang Y,Zhang YL,Sun YP

    更新日期:2012-11-01 00:00:00

  • Neuroimaging studies of factors related to exercise: rationale and design of a 9 month trial.

    abstract::The prevalence of obesity is high resulting from chronic imbalances between energy intake and expenditure. On the expenditure side, regular exercise is associated with health benefits, including enhanced brain function. The benefits of exercise are not immediate and require persistence to be realized. Brain regions as...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章


    authors: Herrmann SD,Martin LE,Breslin FJ,Honas JJ,Willis EA,Lepping RJ,Gibson CA,Befort CA,Lambourne K,Burns JM,Smith BK,Sullivan DK,Washburn RA,Yeh HW,Donnelly JE,Savage CR

    更新日期:2014-01-01 00:00:00

  • The LITE study: Rationale and protocol for a randomized controlled trial of light therapy for cancer-related fatigue in cancer survivors.

    abstract:UNLABELLED:Fatigue is a common and distressing symptom that can last for months or years in up to one-third of cancer survivors. Despite its prevalence, the nature and mechanisms of cancer-related fatigue are poorly understood and the available treatments may not provide sufficient relief. Fatigue has been identified a...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Johnson JA,Garland SN,Carlson LE,Savard J,Simpson JS,Ancoli-Israel S,Campbell TS

    更新日期:2016-07-01 00:00:00

  • Reducing breast cancer recurrence with weight loss, a vanguard trial: the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial.

    abstract::Breast cancer is the most common invasive cancer among women in developed countries. Obesity is a major risk factor for breast cancer recurrence and mortality in both pre- and postmenopausal women. Co-morbid medical conditions are common among breast cancer survivors. The Exercise and Nutrition to Enhance Recovery and...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Rock CL,Byers TE,Colditz GA,Demark-Wahnefried W,Ganz PA,Wolin KY,Elias A,Krontiras H,Liu J,Naughton M,Pakiz B,Parker BA,Sedjo RL,Wyatt H,Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial Group.

    更新日期:2013-03-01 00:00:00

  • Extended-release naltrexone to prevent relapse among opioid dependent, criminal justice system involved adults: rationale and design of a randomized controlled effectiveness trial.

    abstract:BACKGROUND:Extended-release naltrexone (XR-NTX, Vivitrol; Alkermes Inc.) is an injectable monthly sustained-release mu opioid receptor antagonist. XR-NTX is a potentially effective intervention for opioid use disorders and as relapse prevention among criminal justice system (CJS) populations. METHODS:This 5-site open-...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Lee JD,Friedmann PD,Boney TY,Hoskinson RA Jr,McDonald R,Gordon M,Fishman M,Chen DT,Bonnie RJ,Kinlock TW,Nunes EV,Cornish JW,O'Brien CP

    更新日期:2015-03-01 00:00:00

  • A multi-centre prospective development study evaluating focal therapy using high intensity focused ultrasound for localised prostate cancer: The INDEX study.

    abstract:INTRODUCTION:Focal therapy offers the possibility of cancer control, without the side effect profile of radical therapies. Early single centre prospective development studies using high intensity focused ultrasound (HIFU) have demonstrated encouraging genitourinary functional preservation and short-term cancer control....

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,多中心研究


    authors: Dickinson L,Ahmed HU,Kirkham AP,Allen C,Freeman A,Barber J,Hindley RG,Leslie T,Ogden C,Persad R,Winkler MH,Emberton M,INDEX Study Group.

    更新日期:2013-09-01 00:00:00

  • The use of minimization in clinical trials.

    abstract::Since its introduction in 1974 the use of the term Minimization has been broadened to include other algorithms. All algorithms use patient characteristics to determine the assignment that produces the best overall balance between treatment groups. They differ in whether or not they use all of the data from each previo...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,meta分析,评审


    authors: Taves DR

    更新日期:2010-03-01 00:00:00

  • Efficacy of a smoking quit line in the military: baseline design and analysis.

    abstract::Thirty percent of all military personnel smoke cigarettes. Because of the negative health consequences and their impact on physical fitness, overall health, and military readiness, the Department of Defense has identified the reduction of tobacco use as a priority of US military forces. This study aims to evaluate the...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Richey PA,Klesges RC,Talcott GW,Debon M,Womack C,Thomas F,Hryshko-Mullen A

    更新日期:2012-09-01 00:00:00

  • Optimal treatment for women with a persisting pregnancy of unknown location, a randomized controlled trial: The ACT-or-NOT trial.

    abstract:OBJECTIVE:Pregnancy of unknown location (PUL) is not a diagnosis but a transient state used to classify a woman when she has a positive pregnancy test without definitive evidence of an intra-uterine or extra-uterine pregnancy on transvaginal ultrasonography. Management of a persisting PUL varies substantially, includin...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Barnhart KT,Sammel MD,Stephenson M,Robins J,Hansen KR,Youssef WA,Santoro N,Eisenberg E,Zhang H,NICHD Cooperative Reproductive Medicine Network.

    更新日期:2018-10-01 00:00:00

  • Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics.

    abstract:BACKGROUND:Functional dyspepsia (FD) is a common problem affecting up to 10-25% of individuals. FD accounts for significant health care costs and affects quality of life but has no definitive treatment. OBJECTIVES:The Functional Dyspepsia Treatment Trial (FDTT) aims to test whether treatment with an antidepressant (am...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Talley NJ,Locke GR 3rd,Herrick LM,Silvernail VM,Prather CM,Lacy BE,DiBaise JK,Howden CW,Brenner DM,Bouras EP,El-Serag HB,Abraham BP,Moayyedi P,Zinsmeister AR

    更新日期:2012-05-01 00:00:00

  • Commonly performed procedures in clinical research: a benchmark for payment.

    abstract::Slow or insufficient enrollment in clinical research and a high demand for research participants raises questions about the need for and use of incentives to participate, including payment. Much of the available literature on payment to research participants focuses on ethical concerns, and rarely addresses guidelines...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章


    authors: Dominguez D,Jawara M,Martino N,Sinaii N,Grady C

    更新日期:2012-09-01 00:00:00

  • Can atorvastatin with metformin change the natural history of prostate cancer as characterized by molecular, metabolomic, imaging and pathological variables? A randomized controlled trial protocol.

    abstract:BACKGROUND:Atorvastatin and metformin are known energy restricting mimetic agents that act synergistically to produce molecular and metabolic changes in advanced prostate cancer (PCa). This trial seeks to determine whether these drugs favourably alter selected parameters in men with clinically-localized, aggressive PCa...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Roberts MJ,Yaxley JW,Coughlin GD,Gianduzzo TR,Esler RC,Dunglison NT,Chambers SK,Medcraft RJ,Chow CW,Schirra HJ,Richards RS,Kienzle N,Lu M,Brereton I,Samaratunga H,Perry-Keene J,Payton D,Oyama C,Doi SA,Lavin MF,Gar

    更新日期:2016-09-01 00:00:00

  • Long-term Exercise After Pulmonary Rehabilitation (LEAP): Design and rationale of a randomized controlled trial of Tai Chi.

    abstract:BACKGROUND:Persons with chronic obstructive pulmonary disease (COPD) have reduced exercise capacity and levels of physical activity. Supervised, facility-based pulmonary rehabilitation programs improve exercise capacity and reduce dyspnea, but novel long-term strategies are needed to maintain the benefits gained. Mind-...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Moy ML,Wayne PM,Litrownik D,Beach D,Klings ES,Davis RB,Yeh GY

    更新日期:2015-11-01 00:00:00

  • Rationale and design of a trial on the role of bosentan in Fontan patients: improvement of exercise capacity?

    abstract:BACKGROUND:The Fontan circulation is a palliative procedure performed in patients with complex congenital heart disease (CHD), making transpulmonary blood flow dependent on the systemic venous pressure. In a Fontan circulation a low pulmonary vascular resistance (PVR) is crucial, as is epitomized by the observation tha...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Schuuring MJ,Vis JC,Bouma BJ,van Dijk AP,van Melle JP,Pieper PG,Vliegen HW,Sieswerda GT,Mulder BJ

    更新日期:2011-07-01 00:00:00

  • Expansion of the modified Zelen's approach randomization and dynamic randomization with partial block supplies at the centers to unequal allocation.

    abstract::Modified Zelen's approach is a randomization technique useful in multi-center trials where balance in treatment assignments within a center is desired. It has great balancing properties in a study with equal allocation to several treatment arms. This technique can also be used in studies with unequal allocation, where...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,评审


    authors: Kuznetsova OM,Tymofyeyev Y

    更新日期:2011-11-01 00:00:00

  • The HealthyTexts study: a randomized controlled trial to improve skin cancer prevention behaviors among young people.

    abstract::Several randomized trials have found behavior change programs delivered via text messaging to be efficacious to improve preventive health behaviors such as physical activity and stopping smoking; however few have assessed its value in skin cancer prevention or early detection. The HealthyTexts study enrolled 678 parti...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Janda M,Youl P,Marshall AL,Soyer HP,Baade P

    更新日期:2013-05-01 00:00:00

  • ELEctroconvulsive therapy (ECT) vs. Ketamine in patients with Treatment-resistant Depression: The ELEKT-D study protocol.

    abstract::Major depressive disorder (MDD) is the most common mental illness and the leading cause of disability worldwide. Electroconvulsive therapy (ECT) is the most effective treatment for MDD and the gold-standard therapy for treatment-resistant depression (TRD), yet it remains underutilized due to factors such as limited av...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Mathew SJ,Wilkinson ST,Altinay M,Asghar-Ali A,Chang LC,Collins KA,Dale RM,Hu B,Krishnan K,Kellner CH,Malone DA,Murrough JW,Ostroff RB,Sanacora G,Shao M,Anand A

    更新日期:2019-02-01 00:00:00

  • The feasibility and acceptability of a diet and exercise trial in overweight and obese black breast cancer survivors: The Stepping STONE study.

    abstract:PURPOSE:Black breast cancer survivors have high rates of obesity and low physical activity levels. Little is known about the acceptability and feasibility of interventions in this population. OBJECTIVE:A two-arm RCT was launched to assess the efficacy of a culturally targeted 12-week multimodal lifestyle intervention ...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Sheppard VB,Hicks J,Makambi K,Hurtado-de-Mendoza A,Demark-Wahnefried W,Adams-Campbell L

    更新日期:2016-01-01 00:00:00

  • Bridging blinded and unblinded analysis for ongoing safety monitoring and evaluation.

    abstract::In order to better characterize the safety profile of investigational new drugs (INDs) during clinical development, more interest and attention have been paid to ongoing safety monitoring and evaluation. The 2015 US FDA IND safety reporting draft guidance compels sponsors to periodically evaluate unblinded safety data...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章


    authors: Lin LA,Zhan Y,Li H,Yuan SS,Ball G,Wang W

    更新日期:2019-08-01 00:00:00

  • Dose-response effects of exercise on abdominal obesity and risk factors for cardiovascular disease in adults: study rationale, design and methods.

    abstract::Although progress has been made to elucidate the effects of exercise as a strategy for reducing obesity and related cardiometabolic risk factors, the specific exercise exposures required to achieve optimal benefit continue to be the source of considerable uncertainty and debate. Despite the inference of a dose-depende...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Ross R,Hudson R,Day AG,Lam M

    更新日期:2013-01-01 00:00:00

  • Rationale and Design for a Randomized Comparison of Efficacy and Safety between Aspirin and Clopidogrel in Atrial Fibrillation Patients with Low Stroke Risk: CESAC-AF trial.

    abstract:BACKGROUND:Atrial fibrillation (AF) increases the risk of thromboembolic stroke. An oral anticoagulant should be administrated to prevent stroke in patients with moderate stroke risk (ie, CHA2DS2-VASc score>2). If the stroke risk is low (i.e. the score=1), however, antiplatelet agent such as aspirin is widely used. Asp...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Park SM,Jeong H,Jung MH,Hong KS,Hong MK,Bang CS,Kim CY

    更新日期:2017-09-01 00:00:00

  • Improving family caregiver and patient outcomes in lung cancer surgery: Study protocol for a randomized trial of the multimedia self-management (MSM) intervention.

    abstract:OBJECTIVE:To describe the study protocol of the Multimedia Self-Management (MSM) intervention to prepare patients and family caregivers (FCGs) for lung cancer surgery. DESIGN:The study is a five-year, single site, randomized controlled trial of 160 lung cancer surgery FCG and patient dyads (320 total participants), co...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章


    authors: Sun V,Raz DJ,Erhunmwunsee L,Ruel N,Carranza J,Prieto R,Ferrell B,Krouse RS,McCorkle R,Kim JY

    更新日期:2019-08-01 00:00:00

  • Design and protocol of a randomized multiple behavior change trial: Make Better Choices 2 (MBC2).

    abstract:BACKGROUND:Suboptimal diet and inactive lifestyle are among the most prevalent preventable causes of premature death. Interventions that target multiple behaviors are potentially efficient; however the optimal way to initiate and maintain multiple health behavior changes is unknown. OBJECTIVE:The Make Better Choices 2...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Pellegrini CA,Steglitz J,Johnston W,Warnick J,Adams T,McFadden HG,Siddique J,Hedeker D,Spring B

    更新日期:2015-03-01 00:00:00

  • Improving depression treatment for women: integrating a collaborative care depression intervention into OB-GYN care.

    abstract:BACKGROUND:Women have higher rates of depression and often experience depression symptoms during critical reproductive periods, including adolescence, pregnancy, postpartum, and menopause. Collaborative care intervention models for mood disorders in patients receiving care in an OB-GYN clinic setting have not been eval...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: LaRocco-Cockburn A,Reed SD,Melville J,Croicu C,Russo JE,Inspektor M,Edmondson E,Katon W

    更新日期:2013-11-01 00:00:00

  • Rationale and design of Smart Walk: A randomized controlled pilot trial of a smartphone-delivered physical activity and cardiometabolic risk reduction intervention for African American women.

    abstract:BACKGROUND:African American (AA) women perform low levels of physical activity (PA) and are disproportionally burdened by cardiometabolic disease conditions when compared to White women and the U.S. population as a whole. These disparities emphasize the need for innovative and effective interventions to increase PA and...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Joseph RP,Ainsworth BE,Vega-López S,Adams MA,Hollingshead K,Hooker SP,Todd M,Gaesser GA,Keller C

    更新日期:2019-02-01 00:00:00

  • The women in steady exercise research (WISER) survivor trial: The innovative transdisciplinary design of a randomized controlled trial of exercise and weight-loss interventions among breast cancer survivors with lymphedema.

    abstract:INTRODUCTION:Breast cancer survivors face dual challenges: long term sequelae of treatment, and risk of recurrent disease. Obesity and a sedentary lifestyle complicate both challenges. The WISER Survivor trial assessed the effects of exercise and/or weight-loss on lymphedema, biomarkers of breast cancer recurrence, and...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Winkels RM,Sturgeon KM,Kallan MJ,Dean LT,Zhang Z,Evangelisti M,Brown JC,Sarwer DB,Troxel AB,Denlinger C,Laudermilk M,Fornash A,DeMichele A,Chodosh LA,Schmitz KH

    更新日期:2017-10-01 00:00:00