Maternal Overt Hypothyroidism and Neurobehavioral Outcome of Neonates: A Cohort Study from an Iodine-deficient Area of Northern India.

Abstract:

OBJECTIVE:To study the relation between maternal overt hypothyroidism and neurodevelopmental outcome of neonates in iodine-deficient region of Northern India (Kashmir Valley). DESIGN:Prospective cohort study. SETTING:Endocrinology department of a tertiary-care hospital. PARTICIPANTS:82 hypothyroid pregnant women were enrolled and followed up till delivery. The neonates born to this group represented the case neonates. 51 euthyroid healthy pregnant women were selected as control group. The neonates born to these mothers served as controls. MAIN OUTCOME MEASURES:Early neonatal behavioral assessment at 3-4 weeks of age. RESULTS:The mean TSH and free T4 in neonates of mothers with well controlled hypothyroidism was significantly different from those born to mothers with poorly controlled hypothyroidism and controls in 1st trimester, but the difference was statistically insignificant for 2nd and 3rd trimester values. CONCLUSION:Overt maternal hypothyroidism in iodine-deficient area constitutes a risk factor for an abnormal neurobehavioral development of affected child.

journal_name

Indian Pediatr

journal_title

Indian pediatrics

authors

Ganaie MA,Charoo BA,Sofi RA,Ahmed A,Bhat JI

doi

10.1007/s13312-015-0733-8

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

864-6

issue

10

eissn

0019-6061

issn

0974-7559

journal_volume

52

pub_type

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