[Treatment and results of the first relapse of acute lymphatic leukemia in childhood (author's transl)].


:In our experience the prognosis of hematological relapse in patients with acute lymphatic leukemia treated according to the Pinkel programme is very bad. It may be a little better for patients in whom relapse occurred after the end of therapy and who were submitted to intensified cytostatic treatment. The chances for achieving a second long-term remission, if the relapse is confined to the CNS, are also better. This is true particularly for those patients who in addition were given radiotherapy. In recurrence in the testes radiotherapy alone will not suffice and additional intensified cytosatic treatment should be considered.


Klin Padiatr


Klinische Padiatrie


Gröbe H,Schellong G


Has Abstract


1977-01-01 00:00:00












  • Bleeding and thrombosis in children with acute lymphoblastic leukaemia, treated according to the ALL-BFM-90 protocol.

    abstract::A multi-center retrospective survey was conducted to evaluate the incidence and types of hemostatic complications occurring in children with acute lymphoblastic leukemia (ALL) during treatment according to the ALL-BFM-90 treatment protocol. All of the BFM-treatment centers (n = 77) were approached and a 95% response r...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章,多中心研究


    authors: Sutor AH,Mall V,Thomas KB

    更新日期:1999-07-01 00:00:00

  • [Cow's milk allergy: guidelines for the diagnostic evaluation].

    abstract::About 2% of the general population and up to 6% of children suffer from food allergy. Cow's milk is charged with a important role in infancy after weaning, since conventional formula are based on its procession. IgE-mediated and Non-IgE- mediated allergic reactions, which are different in manifestation and pathogenesi...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Kirchlechner V,Dehlink E,Szepfalusi Z

    更新日期:2007-07-01 00:00:00

  • Betulinic acid: a new chemotherapeutic agent in the treatment of neuroectodermal tumors.

    abstract::We identified betulinic acid (BetA) as a new cytotoxic agent active against neuroectodermal tumor cells including neuroblastoma, medulloblastoma, glioblastoma and Ewing's sarcoma cells representing the most common solid tumors of childhood. BetA induced apoptosis independent of wild-type p53 protein and accumulation o...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Fulda S,Jeremias I,Pietsch T,Debatin KM

    更新日期:1999-07-01 00:00:00

  • Painful scoliosis.

    abstract::In case of painful scoliosis, a search for etiologic factors in the vertebral spinal canal and adjacent structures should be made. MRI with Gadolinium is useful to look for various pathology in and around the spine in particular of spinal cord. CT scanning is indispensible for bony details. Thus CT and MRI are complem...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章,评审


    authors: Hoeffel C,Gaucher H,Hoeffel JC,Galloy MA,Arnould V

    更新日期:1997-03-01 00:00:00

  • [A familial brain malformation syndrome with symptomatic hypernatremia].

    abstract::A familial cerebral malformation combined with chronic hypernatremia is reported. We found three children of a Moroccan family with microcephaly and hypoplasia of the frontal brain. The frontal parts of the lateral ventricles were absent. Two of the children had a defect of the midline structures with fusion of the la...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Franek A,Böcker H,Kahlen T

    更新日期:1986-09-01 00:00:00

  • Laryngomalacia and complicated, life-threatening mTOR-positive Kaposiform hemangioendothelioma cured by Supraglottoplasty and sirolimus.

    abstract::The therapy of complicated Kaposiform hemangioendothelioma (KHE) is still difficult. We present the first case of laryngomalacia with simultaneous mammalian target of Rapamycin (mTOR)-positive KHE of the neck and thoracic inlet and concurrent Kasabach-Meritt Phenomenon (KMP) in an 11-month-old boy suffering life-threa...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Schroeder U,Lauten M,Stichtenoth G,Gebhard MP,Buchholz M,Kaiser MM

    更新日期:2014-11-01 00:00:00

  • Calcium and phosphor intake in preterm infants: sensitivity and specifity of 6-hour urine samples to detect deficiency.

    abstract::Aim of the present study was to test whether six-hour (6 h) urine specimens predict the 24-hour (24 h) mineral homeostasis in individual infants born preterm. Urinary Calcium (Ca) and Phosphate (P) concentrations were studied in 60 stable infants; gestational age 34 (25-42) weeks. In 58 infants four 6 h urine specimen...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Mihatsch W,Trotter A,Pohlandt F

    更新日期:2012-03-01 00:00:00

  • Allogeneic hematopoietic stem cell transplantation in Glanzmann thrombasthenia complicated by platelet alloimmunization.

    abstract:BACKGROUND:For Thrombasthenia Glanzmann (GT) patients presenting with a severe clinical phenotype due to complete lack of thrombocyte function or increased titres of anti-platelet antibodies hematopoietic stem cell transplantation (SCT) is the only curative therapy. CASE REPORT:We report the case of a 13-month-old boy...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Wiegering V,Winkler B,Langhammer F,Wölfl M,Wirbelauer J,Sauer K,Kobsar A,Meyer T,Strauss A,Bakchoul T,Eyrich M,Schlegel PG

    更新日期:2011-05-01 00:00:00

  • Symptom patterns in childhood arterial ischemic stroke: Analysis of a population-based study in Germany.

    abstract:HINTERGRUND: Die zeitliche Verzögerung zwischen Symptombeginn und Diagnose ist eine Herausforderung in der Behandlung von Kindern mit arteriell ischämischem Schlaganfall. Frühere Studien zur klinischen Präsentation beschäftigten sich v. a. mit kumulativen Symptomen. ZIELSETZUNG: Ziel dieser Studie ist es, mögliche Sym...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Gerstl L,Weinberger R,von Kries R,Heinen F,Sebastian Schroeder A,Veronika Bonfert M,Borggräfe I,Tacke M,Vill K,N Landgraf M,Kurnik K,Olivieri M

    更新日期:2018-10-01 00:00:00

  • [Lumbar cisternography in the evaluation of hydrocephalus in premature infants].

    abstract::Radionuclide lumbar cisternography with 111In-DTPA was utilized as a bedside procedure to evaluate CSF dynamics and the patency of the ventricular system in 29 preterm infants with hydrocephalus. Serial images of the brain were obtained at 0, 1, 2, 6, 24 and 48 hours after instillation of the isotope in the lumbar sub...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Roloff DW

    更新日期:1985-03-01 00:00:00

  • [A case of X/X translocation: t(X;X) (q26;p11)].

    abstract::An eight-year old girl showing a X/X-translocation (45,X/46,Xt(X;X)(q26;p11)) is presented. Besides short stature and congenital heart-anomaly no other phenotypical abnormalities were present. In all cells containing the abnormal X-chromosome, the latter was late labeling as shown by autoradiography and BrdU-labeling....

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Wagenbichler P,Frisch H,Schnedl W

    更新日期:1975-11-01 00:00:00

  • [Longitudinal data of physical growth of healthy children. III. Circumferences of thorax, upper arm, thigh and calf of children aged 2 to 15 years (author's transl)].

    abstract::From 1968--1978 a longitudinal study was performed concerning development of thorax, upper arm, thigh and calf circumferences in 709 boys and 711 girls 2--15 years old. In boys the mean increase in thoracic circumference amounted to 32.9 cm, in upper are circumference to 8.3 cm, in thigh circumference to 20.6 cm and i...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Reinken L,Stolley H,Droese W,van Oost G

    更新日期:1980-01-01 00:00:00

  • [Acute erythromelalgia with hypertension in a 5-year old boy].

    abstract:BACKGROUND:Burning pain of red and warm hands and/or feet are the classical symptoms of erythromelalgia. CASE REPORT:We describe the symptoms of acute idiopathic erythromelalgia and arterial hypertension in a five-year-old boy. Five days after a gastroenteritis the patient developed burning hands and feet in combinati...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Zenz W,Zöhrer B,Zobel G,Schulze-Bauer C

    更新日期:1999-11-01 00:00:00

  • [New concepts of corticosteroid treatment in pulmonary diseases of the premature infant].

    abstract::Corticosteroids for treatment or prevention of pulmonary disease are milestones in the management of preterm infants nowadays. Prenatal maternal administration as well as postnatal treatment of the mechanically ventilated preterm infant with bronchopulmonary dysplasia (BPD) are considered to be established concepts. H...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章,评审


    authors: Krause M

    更新日期:1997-09-01 00:00:00

  • Tumorangiogenesis: a network of cytokines.

    abstract::During angiogenesis new blood vessels sprout from an existing vascular bed. This is a prerequisite for tumor growth beyond a certain size and for metastasis formation. Tumors produce a number of cytokines. The development of in vivo bio-assays for angiogenesis and in vitro analysis of endothelial cells permits charact...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章,评审


    authors: Hotfilder M,Nowak-Göttl U,Wolff JE

    更新日期:1997-07-01 00:00:00

  • [Postoperative sonographic follow-up of brain tumors in childhood].

    abstract::Postoperative neurosonography was performed in 69 babies and children after osteoclastic neurosurgery for primary cerebral tumors. Astrocytoma of the posterior fossa (26 cases) and medulloblastoma (25 cases) were frequent histological findings. Early postoperative bed-side examinations revealed reliably complications ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Dittrich M,Gutjahr P,Dinkel E,Higer HP,Müller W

    更新日期:1987-11-01 00:00:00

  • Extending the Concept of Advance Care Planning to the Perinatal Period.

    abstract::Easier access to prenatal diagnostic procedures led to its widespread use as a screening measure. Hence, today it is more common for life-limiting illnesses to be diagnosed during fetal life. The concept of Advance Care Planning (ACP) provides a framework for caregivers, families and their multidisciplinary teams to a...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章,评审


    authors: Garten L,von der Hude K,Strahleck T,Krones T

    更新日期:2020-09-01 00:00:00

  • Hematopoietic stem cell transplantation for severe combined immunodeficiency.

    abstract::Severe combined immunodeficiency (SCID) is a heterogeneous group of congenital diseases characterized by their presentation with life threatening infections in the first months of life. The clinical presentation and the therapeutic outcome is influenced by multiple factors: the genetic defect, infectious complications...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章,评审


    authors: Hönig M,Schulz A,Friedrich W

    更新日期:2011-11-01 00:00:00

  • Clinical outcome of patients with childhood acute lymphoblastic leukaemia and an initial leukaemic blood blast count of less than 1000 per microliter.

    abstract:BACKGROUND:One of the strongest predictive factors for therapy outcome in childhood acute lymphoblastic leukaemia (ALL), treated according to ALL-BFM protocols, is the response to initial prednisone treatment. Prednisone response is characterized by the peripheral leukaemic blast count. The threshold value for the char...

    journal_title:Klinische Padiatrie

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lauten M,Stanulla M,Zimmermann M,Welte K,Riehm H,Schrappe M

    更新日期:2001-07-01 00:00:00

  • [Toxocariasis--a neglected ubiquitous helminthiasis in children and adolescents].

    abstract::More than 40 years ago, Toxocara ssp. was identified as the cause of larva migrans visceralis and ocular larva migrans, which mainly affect infants and children. Although widespread in most parts of the world, the parasitic disease is rarely diagnosed in Germany. Focusing on clinical and pathophysiological similaritie...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章,评审


    authors: Hohenschild S

    更新日期:1998-05-01 00:00:00

  • [Transcutaneous measurements of pO2 in newborns with RDS (author's transl)].

    abstract::pO2 was measured transcutaneously (commercially available Clark Electrode, Bioelectronics Roche) with two different electrode temperatures in new born infants. The correlation between paO2 (arteria radialis) and ptcO2 was bad (r= 0,74) with electrode temperature of 42 degrees C. When the electrode was heated to 44 deg...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Haschke F,Häckel F,Hohenauer L

    更新日期:1976-01-01 00:00:00

  • [Non-Hodgkin's lymphomas in the oropharynx in children - a histological study in 11 patients].

    abstract::In the period from 1965 to 1979 biopsies from the oropharynx of 11 children with non-Hodgkin's lymphoma were collected at the Lymph Node Registry in Kiel. Palatine tonsil tissue was examined in all cases and, in addition, specimens from the retrolingual region of one child and the epipharynx of two patients. All biops...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Schwarze EW,Mrowietz B,van Ackeren G

    更新日期:1983-05-01 00:00:00

  • [Purulent pericarditis during abscess-forming pneumonia].

    abstract::The case is described of a 6 months old infant who developed purulent pericarditis during the course of pneumonia. Pericarditis probably developed in this condition by contiguous spread from the pleura. Diagnosis of impending cardiac tamponade was masked by the occurrence of massive unilateral empyema. The management ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Beitzke A,Trittenwein G,Rigler B,Grubbauer HM,Suppan C

    更新日期:1982-09-01 00:00:00

  • [Comparison of chemotherapy alone with allogeneic bone marrow transplantation in first full remission in children with acute myeloid leukemia in the AML-BFM-83 and AML-BFM-87 studies--matched pair analysis].

    abstract::16 patients of studies AML-BFM-83 and -87 with allogeneic bone marrow transplantation (BMT) in first complete remission (CR) were compared with matched controls with postremission chemotherapy (CT-MC). CT-MC were selected from 250 non-grafted patients with a minimum of remission duration corresponding to the median in...

    journal_title:Klinische Padiatrie

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Creutzig U,Bender-Götze C,Klingebiel T,Ebell W,Friedrich W,Stollmann-Gibbels B,Schmidt H,Suttorp M,Gratwohl A,Heyen P

    更新日期:1992-07-01 00:00:00

  • Health related quality of life after corrective surgery for congenital heart disease.

    abstract:UNLABELLED:After corrective surgery for congenital heart defects (CHD) many patients suffer from residual defects, some with reduced cardiorespiratory capacity and possible impairment of their health related quality of life (HRQoL). The aim of our study is to evaluate, how children after surgery for CHD rate their HRQo...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Heusch A,Calaminus G,Kahl J,Schmidt K

    更新日期:2014-09-01 00:00:00

  • Drug handling in a paediatric intensive care unit--can errors be prevented by a three-step intervention?

    abstract:BACKGROUND:Drug handling in paediatric intensive care units (PICU) is prone to medication errors. We aimed to identify type and prevalence of those errors and to assess preventative interventions. METHODS:Prospective intervention study investigating a 3-step intervention for preventing errors in drug handling in a 10-...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Niemann D,Bertsche A,Meyrath D,Oelsner S,Ewen AL,Pickardt B,Henhapl T,Hoffmann G,Meyburg J,Bertsche T

    更新日期:2014-04-01 00:00:00

  • [Neonatal suppurative parotitis].

    abstract::This report describes the case of a 10 days old newborn of a diabetic mother with gestosis, who developed erythema and swelling of the right cheek. A diagnosis of acute suppurative parotitis due to S. aureus was made. Following this case report the most important facts of epidemiology, pathogenesis, clinical manifesta...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Möckel A,Nissler K,Wilhelm T,Handrick W

    更新日期:2005-03-01 00:00:00

  • [Initial response to therapy as an important prognostic factor in acute lymphoblastic leukemia in childhood. COALL study group].

    abstract::Prognostic factors to estimate the risk of relapse are crucial for risk-adapted therapy in acute lymphoblastic leukemia (ALL). In a cooperative multicenter treatment study for childhood ALL (COALL-03-85) the prognostic relevance of the bone marrow (BM) blast count at day 28 was evaluated. Treatment was adjusted to the...

    journal_title:Klinische Padiatrie

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Janka-Schaub GE,Stührk H,Kortüm B,Graubner U,Jürgens H,Spaar HJ,Schöck V,Dohrn B,Bahr R,Winkler K

    更新日期:1991-07-01 00:00:00

  • A Case of Hemophagocytic Lymphohistiocytosis following Refractory Kawasaki Disease.

    abstract::Hemophagocytic lymphohistiocytosis (HLH) is a systemic inflammatory disorder characterized by uncontrolled histiocytic proliferation, hemophagocytosis, macrophage activation, and up-regulation of inflammatory cytokines (Grom AA., Current opinion in rheumatology 2003; 15: 587-590). HLH is usually divided into two types...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Li Y,Wang Y,Li S,Liu M,Wang D,Xu C,Zhang L

    更新日期:2020-02-25 00:00:00

  • [Hepatotoxicity of valproic acid treatment].

    abstract::Hepatotoxicity of valproic acid (VPA) is reported in a psychomotor retarded boy. A four-month antiepileptic therapy was followed by a combined VPA/phenytoin treatment where-upon, two months later, the patient died in a hepatic coma. In the final state the metabolic pattern of VPA was still found within the normal rang...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章


    authors: Keulen FP,Kochen W

    更新日期:1985-09-01 00:00:00