Abstract:
UNLABELLED:Tubulointerstitial fibrosis and tubular atrophy play a crucial role in the pathogenesis of chronic kidney disease (CKD). They are also major determinants in chronic kidney disease development and progression in patients with primary renal diseases characterized by persistent or recurrent proteinuria. The purpose of the study was to assess urinary excretion of alpha-glutathione S-transferase (alpha-GST), pi-glutathione S-transferase (pi-GST), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and serum NGAL level in children with idiopathic nephrotic syndrome (INS). PATIENTS AND METHODS:the study group comprised of 39 children with INS and the control group consisted of 20 healthy children. A total of 23 patients were affected with steroid-dependent nephrotic syndrome (SDNS) and 16 with steroid-resistant nephrotic syndrome (SRNS). In the majority of patients, a histopathologic examination revealed minimal change disease (MCD)-25 (64%). Focal segmental glomerulosclerosis (FSGS), mesangioproliferative glomerulonephritis (MesPGN), membranoproliferative glomerulonephritis (MPGN), and membranous glomerulonephritis (MGN) were diagnosed in 4 (10.3 %), 6 (15.5%), 2 (5.1%), and 2 (5.1%) children, respectively. Urinary alpha-GST, urinary pi-GST, urinary KIM-1, and urinary and serum NGAL concentrations were measured using specific enzyme-linked immunosorbent assay. The urinary results were expressed in nanograms per milligram of creatinine (ng/mg). RESULTS:The authors observed significantly higher levels of urinary alpha-GST/creatinine ratio (P = 0.03), urinary KIM-1/creatinine ratio (P < 0.02), serum NGAL level (P < 0.01), and urinary NGAL/creatinine ratio (P = 0.02) in children with INS compared with controls. The median values of urinary pi-GST/creatinine ratio in children with INS and controls did not differ significantly. In children with SRNS, the median values of urinary NGAL/creatinine ratio (P = 0.02) and urinary KIM-1/creatinine ratio (P = 0.02) were significantly higher compared with children with SDNS. The authors noted significant positive correlation between KIM-1/creatinine ratio and proteinuria (r = 0.56, P < 0.05). The analysis of alpha-GST/creatinine ratio, pi-GST/creatinine ratio, sNGAL, and uNGAL/creatinine ratio concerning the histopathologic examination, the duration of the disease, and number of relapses did not show any significant differences. CONCLUSIONS:1. Both children with SDNS and those with SRNS were characterized by increased tubular injury marker levels. 2. Patients with SRNS and higher proteinuria are more susceptible to early kidney damage.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Bieniaś B,Zajączkowska M,Borzęcka H,Sikora P,Wieczorkiewicz-Płaza A,Wilczyńska Bdoi
10.1097/MD.0000000000001746subject
Has Abstractpub_date
2015-10-01 00:00:00pages
e1746issue
42eissn
0025-7974issn
1536-5964pii
00005792-201510030-00039journal_volume
94pub_type
杂志文章相关文献
MEDICINE文献大全abstract:BACKGROUND:Microsurgery is widely utilized for patients with cerebral hemorrhage (CH). The purpose of this study is to assess the efficacy and safety of microsurgery for the treatment of patients with CH secondary to gestational hypertension (GH). METHODS:Relevant randomized controlled trials in eight electronic datab...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017558
更新日期:2019-10-01 00:00:00
abstract::Inhalation anesthetics provide myocardial protection for cardiac surgery. This study was undertaken to compare the perioperative effects between isoflurane and fentanyl-midazolam-based anesthesia for heart transplantation. A retrospective cohort study was conducted by reviewing the medical records of heart transplanta...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004699
更新日期:2016-08-01 00:00:00
abstract::Chronic hepatitis B (CHB) remains a global health problem. Therapeutic vaccination has been successfully employed to treat a subpopulation of CHB patients. Personalized treatment can not only improve therapeutic efficacy, but also decrease the cost of medical care. Since microRNAs (miRNAs) are highly conserved and are...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000002511
更新日期:2016-01-01 00:00:00
abstract::Molar-incisor malformation (MIM) is a recently defined dental abnormality of molar root and incisors, and introduced as one of the causes of periapical and periodontal abscess. The purpose of this study was to investigate the clinical and radiological features of MIM, with special emphasis on various medical history. ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017356
更新日期:2019-10-01 00:00:00
abstract:ABSTRACT:To assess diagnostic criteria and currently used tools for the identification of central sensitization (CS) in patients with joint pain due to osteoarthritis (OA).Qualitative, cross-sectional and multicenter study based on a 2-round Delphi surveyPublic and private medical centers attending patients with joint ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023470
更新日期:2020-12-24 00:00:00
abstract::The incidence of acute myocarditis complicated with ventricular tachycardia (VT) is unknown. This study aimed to investigate the association between myocarditis and the incidence of VT and mortality. We also aimed to determine the independent predictors that increased the VT risk in those patients. From 2000 to 2004, ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006633
更新日期:2017-05-01 00:00:00
abstract::The present study was to analyze clinical outcome of Pauwels grade-3 femoral neck fractures treated by different surgical techniques. Potential risk factors associated with nonunion and osteonecrosis of the femoral head (ONFH) were investigated as well. The retrospective study comprised of 67 sequential patients treat...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003706
更新日期:2016-06-01 00:00:00
abstract::To evaluate the utility of blood pressure variability (BPV) calculated using previously published and newly introduced indices using the variables falls and age as comparators.While postural hypotension has long been considered a risk factor for falls, there is currently no documented evidence on the relationship betw...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003614
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The prognostic significance of phosphatase and tensin homolog (PTEN) in patients with breast cancer (BC) remains controversial. The aims of our meta-analysis are to evaluate its association with clinicopathological characteristics and prognostic value in patients with breast cancer. METHODS:PubMed, EMBASE, ...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000008000
更新日期:2017-09-01 00:00:00
abstract::Our Renal Care Center (RCC) is a separate building, performing almost 2500 outpatient dialysis runs per month. In May 2007, 2 patients developed, days apart, bacteremia with an apparently identical nonfermentative Gram-negative rod. Because of difficulty identifying the organism, testing in the Biolog system identifie...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0b013e3181aede29
更新日期:2009-07-01 00:00:00
abstract::To summary the impact of off-pump coronary artery bypass grafting (CABG) only on patients with moderate ischemic mitral regurgitation and survival.We retrospectively analyzed 109 patients with coronary artery disease (CAD) complicated by moderate mitral regurgitation, from January, 2008 to December, 2014, in the Depar...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014969
更新日期:2019-04-01 00:00:00
abstract::There is little information about the management and clinical outcomes of the periprosthetic fracture after total knee arthroplasty (TKA) with a stem extension. The purposes of this study were to demonstrate management of the periprosthetic fractures after TKA with a stem extension, to report treatment outcomes, and t...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016088
更新日期:2019-06-01 00:00:00
abstract:RATIONALE:Immunosuppressive agents such as tacrolimus (TAC) and cyclosporin might cause glycemic disorders by suppressing insulin production. However, only a few cases of diabetic ketoacidosis (DKA) with longitudinal evaluation of endogenous insulin secretion related to TAC administration have been reported. PATIENT C...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000016992
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:The digestive tract malignancies are a series of malignant tumor with high morbidity and mortality. Traditional Chinese medicine (TCM) combined with chemotherapy drugs interventions have been applied for the treatment of malignant tumors in Asian countries for dacades. This study aimed to assess the effectiv...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000019480
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:The aim of the study was to compare the clinical outcomes of patients undergoing all-arthroscopic (AA) or mini-open (MO) rotator cuff repair. METHODS:The present study evaluated 50 patients who had undergone AA repair and 50 patients who had undergone MO repair with a minimum 1-year follow-up. Every patient...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000006322
更新日期:2017-03-01 00:00:00
abstract:INTRODUCTION:Periorbital metastasis of colorectal cancer is rare. Therefore, herein, we report a patient with rectal cancer who presented with periorbital metastasis without any systemic metastasis. PATIENT CONCERNS:The patient was a 57-year-old man who had a painless nodule on his left eyelid. DIAGNOSIS:The patient ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018479
更新日期:2020-01-01 00:00:00
abstract::The presence of long-standing hyperglycemic conditions has been suggested to lead to many skin problems associated with an impaired skin barrier function. However, the relationship between impaired skin barrier status and altered peripheral nervous system function has not yet been determined. The purpose of this study...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008611
更新日期:2017-11-01 00:00:00
abstract::This retrospective study compared efficacy and safety of fludarabine combined with intermediate-dose cytarabine (FA regimen) versus high-dose cytarabine (HiDAC regimen) as consolidation therapy in acute myeloid leukemia (AML) patients who achieved complete remission. Disease-free survival (DFS) and overall survival (O...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000134
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of oral ketamine versus oral midazolam for sedation during laceration repair at a pediatric emergency department. METHODS:Children between 1 and 10 years requiring laceration repair were randomly assigned to 2 groups, treated either with oral midazolam (0.7 mg/kg) or with oral ketamine...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000003984
更新日期:2016-06-01 00:00:00
abstract:RATIONALE:Infertile male carrying balanced translocations can be broadly divided into two types: pregestational and gestational infertility. Chromosome and breakpoints involved translocation should be considered in genetic counselling for these patients. To date, > 100 cases have been described with carrying balanced t...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000010452
更新日期:2018-04-01 00:00:00
abstract:RATIONALE:The occurrence of hyperkalemia after esophagectomy is clinically rare. Patients who underwent esophagectomy often have a serum potassium level due to perioperative reduced intake, fluids loss, consumption and other reasons. These patients often require the artificial administration of potassium. Rapid fluid l...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008966
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Parkinson's disease (PD) is the second-most-common chronic and progressive neurodegenerative disease. The long-term use of levodopa leads to a loss of efficacy and to complications. Therefore, many patients with PD have turned to complementary therapies to help relieve their symptoms. Acupuncture is most com...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000005836
更新日期:2017-01-01 00:00:00
abstract::Children who underwent surgery for complex congenital heart defects present worse exercise capacity than their healthy peers. In adults and adolescents, heart failure is assessed on the basis of clinical symptoms using the New York Heart Association (NYHA) score, while in an infant Ross scale; heart failure can also b...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002619
更新日期:2016-02-01 00:00:00
abstract::A nationwide multicenter study was conducted in the China to explore sources of variation of reference values and establish reference intervals for 28 common biochemical analytes, as a part of the International Federation of Clinical Chemistry and Laboratory Medicine, Committee on Reference Intervals and Decision Limi...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000002915
更新日期:2016-03-01 00:00:00
abstract:RATIONALE:Iatrogenic chylous leakage (CL) is a rare but potentially life-threatening complication after neck surgery. In cirrhotic patient, the massive CL is even more intractable and extremely dangerous due to portal hypertension. PATIENTS CONCERNS:A 54-year-old liver cirrhotic patient had milky fluid leakage from le...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009103
更新日期:2017-12-01 00:00:00
abstract::For the prevention of gastric cancer, the detection of risk factors associated with precancerous conditions may be more informative. The aim of this study was to identify the risk factors of gastric cancer, including precancerous conditions: atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia.The clinic...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005351
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Warm needle acupuncture (WNA) is a traditional Chinese medicine (TCM) therapy which combines technical advantages of acupuncture and moxibustion. Climacteric insomnia is a common symptom in climacteric women, which can seriously affect the physical and mental health of patients. Relevant studies have been re...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000015637
更新日期:2019-05-01 00:00:00
abstract::To summarize the clinical features of eyeball rupture with or without orbital fracture and explore the differences between them.In all, 197 patients were observed, and the following data were recorded: sex, age, time of injury, place of injury, cause of trauma, zone of eye injury, intraocular content prolapse, surgica...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007109
更新日期:2017-06-01 00:00:00
abstract:RATIONALE:Toothpick puncture (TPP) is a penetrating injury that can result in bringing pathogens to the deep space. Such penetrating wounds are typically of pinpoint size with initial symptoms appearing subtle. Consequently, the injury itself is often neglected by patients, or is not detected during physical examinatio...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018159
更新日期:2019-11-01 00:00:00
abstract::This study investigated anatomical variations in the confluence types of the right gastroepiploic vein (RGEV) to improve knowledge regarding no. 6 lymphadenectomy for laparoscopic gastrectomy.The RGEV drainage patterns of 144 patients who were diagnosed with gastric cancer and underwent laparoscopic distal gastrectomy...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001383
更新日期:2015-08-01 00:00:00