Abstract:
BACKGROUND:Pseudomonas aeruginosais a frequent nosocomial pathogen that causes severe diseases in many settings. Carbapenems, including meropenem and imipenem, are effective antibiotics against this organism. However, the use of carbapenems has been hampered by the emergence of strains resistant to carbapenemsvia different mechanisms such as the production of metallo-β-lactamases (MBLs), which hydrolyze all carbapenems. Several kinds of MBLs have been reported, among them VIM and IMP types being the most clinically significant carbapenemases. OBJECTIVES:We aimed to determine the distribution of bla VIM-2 and bla IMP-1 transferable genes encoding MBLs in P. aeruginosa isolated from three academic hospitals in Kermanshah. PATIENTS AND METHODS:From 22nd June to 22nd September 2012, 225 isolates of P. aeruginosa were collected. These isolates were tested for antibiotic susceptibility with the Kirby-Bauer disk-diffusion method, and the MBLs were assessed using the imipenem-EDTA double-disk synergy test. The isolates were investigated for bla VIM - 2 and bla IMP-1 genes using polymerase chain reaction. RESULTS:Among the 225 isolates, 33.7% (76/225) and 18.1% (41/225) were resistant to imipenem and meropenem, respectively. Of the 76 imipenem-resistant P. aeruginosa strains, 45 (59.2%) were positive for MBLs, 34 (75%) strains carried the bla IMP-1 gene, and 1 (2.2%) strain carried the bla VIM - 2 gene. CONCLUSIONS:Our results showed that there was a high frequency of IMP-1 positive P. aeruginosa in the different wards of the hospitals.
journal_name
Jundishapur J Microbioljournal_title
Jundishapur journal of microbiologyauthors
Abiri R,Mohammadi P,Shavani N,Rezaei Mdoi
10.5812/jjm.22582subject
Has Abstractpub_date
2015-09-22 00:00:00pages
e22582issue
9eissn
2008-3645issn
2008-4161journal_volume
8pub_type
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