Identification of sensory hair-cell transcripts by thiouracil-tagging in zebrafish.

abstract：BACKGROUND:The transformation of a developing epithelium into an adult structure is a complex process, which often involves coordinated changes in cell proliferation, metabolism, adhesion, and shape. To identify genetic mechanisms that control epithelial differentiation, we analyzed the temporal patterns of gene expres...

journal_title：BMC genomics

authors： O'Keefe DD,Thomas SR,Bolin K,Griggs E,Edgar BA,Buttitta LA

更新日期：2012-09-20 00:00:00

abstract：BACKGROUND:In many eukaryotes, microRNAs (miRNAs) bind to complementary sites in the 3'-untranslated regions (3'-UTRs) of target messenger RNAs (mRNAs) and regulate their expression at the stage of translation. Recent studies have revealed that many miRNAs are evolutionarily conserved; however, the evolution of their t...

journal_title：BMC genomics

authors： Takane K,Fujishima K,Watanabe Y,Sato A,Saito N,Tomita M,Kanai A

更新日期：2010-02-09 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNA molecules that downregulate gene expression by base pairing to the 3'-untranslated region (UTR) of target messenger RNAs (mRNAs). Up to now, rare information for the miRNAs is available in decapod crustaceans. Our previous studies showed that many miRNA-binding sit...

journal_title：BMC genomics

authors： Song YN,Shi LL,Liu ZQ,Qiu GF

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Candida albicans is a diploid pathogenic fungus not yet amenable to routine genetic investigations. Understanding aspects of the regulation of its biological functions and the assembly of its protein complexes would lead to further insight into the biology of this common disease-causing microbial agent. RES...

journal_title：BMC genomics

authors： Lavoie H,Sellam A,Askew C,Nantel A,Whiteway M

更新日期：2008-12-02 00:00:00

abstract：BACKGROUND:Host-specific environmental factors induce changes in Bacillus anthracis gene transcription during infection. A global transcription regulator, CodY, plays a pivotal role in regulating central metabolism, biosynthesis, and virulence in B. anthracis. In this study, we utilized RNA-sequencing to assess changes...

journal_title：BMC genomics

authors： Kim SK,Jung KH,Chai YG

更新日期：2016-08-17 00:00:00

abstract：BACKGROUND:Fatty liver is a high incidence of perinatal disease in dairy cows caused by negative energy balance, which seriously threatens the postpartum health and milk production. It has been reported that lysine acetylation plays an important role in substance and energy metabolism. Predictably, most metabolic proce...

journal_title：BMC genomics

authors： Le-Tian Z,Cheng-Zhang H,Xuan Z,Zhang Q,Zhen-Gui Y,Qing-Qing W,Sheng-Xuan W,Zhong-Jin X,Ran-Ran L,Ting-Jun L,Zhong-Qu S,Zhong-Hua W,Ke-Rong S

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:Two strains of the silver fox (Vulpes vulpes), with markedly different behavioral phenotypes, have been developed by long-term selection for behavior. Foxes from the tame strain exhibit friendly behavior towards humans, paralleling the sociability of canine puppies, whereas foxes from the aggressive strain a...

journal_title：BMC genomics

authors： Kukekova AV,Johnson JL,Teiling C,Li L,Oskina IN,Kharlamova AV,Gulevich RG,Padte R,Dubreuil MM,Vladimirova AV,Shepeleva DV,Shikhevich SG,Sun Q,Ponnala L,Temnykh SV,Trut LN,Acland GM

更新日期：2011-10-03 00:00:00

abstract：BACKGROUND:Nonspecific hybridization is currently a major concern with microarray technology. One of most effective approaches to estimating nonspecific hybridizations in oligonucleotide microarrays is the utilization of mismatch probes; however, this approach has not been used for longer oligonucleotide probes. RESUL...

journal_title：BMC genomics

authors： Deng Y,He Z,Van Nostrand JD,Zhou J

更新日期：2008-10-17 00:00:00

abstract：BACKGROUND:'Systems-wide' approaches such as microarray RNA-profiling are ideally suited to the study of the complex overlapping responses of plants to biotic and abiotic stresses. However, commercial microarrays are only available for a limited number of plant species and development costs are so substantial as to be ...

journal_title：BMC genomics

authors： Davey MW,Graham NS,Vanholme B,Swennen R,May ST,Keulemans J

更新日期：2009-09-16 00:00:00

abstract：BACKGROUND:Milkweeds (Asclepias L.) have been extensively investigated in diverse areas of evolutionary biology and ecology; however, there are few genetic resources available to facilitate and compliment these studies. This study explored how low coverage genome sequencing of the common milkweed (Asclepias syriaca L.)...

journal_title：BMC genomics

authors： Straub SC,Fishbein M,Livshultz T,Foster Z,Parks M,Weitemier K,Cronn RC,Liston A

更新日期：2011-05-04 00:00:00

abstract：BACKGROUND:Mitochondrial genomes (mtDNA) of multicellular animals (Metazoa) with bilateral symmetry (Bilateria) are compact and usually carry 13 protein-coding genes for subunits of three respiratory complexes and ATP synthase. However, occasionally reported exceptions to this typical mtDNA organization prompted specul...

journal_title：BMC genomics

authors： Szafranski P

更新日期：2017-03-31 00:00:00

abstract：BACKGROUND:The objective of this research was to investigate the reproducibility of cross-species microarray hybridisation. Comparisons between same- and cross-species hybridisations were also made. Nine hybridisations between a single pig skeletal muscle RNA sample and three human cDNA nylon microarrays were completed...

journal_title：BMC genomics

authors： Moody DE,Zou Z,McIntyre L

更新日期：2002-09-27 00:00:00

abstract：BACKGROUND:The spiral cleavage mode of early development is utilized in over one-third of all animal phyla and generates embryonic cells of different size, position, and fate through a conserved set of stereotypic and invariant asymmetric cell divisions. Despite the widespread use of spiral cleavage, regulatory and mol...

journal_title：BMC genomics

authors： Chou HC,Pruitt MM,Bastin BR,Schneider SQ

更新日期：2016-08-05 00:00:00

abstract：BACKGROUND:Magnaporthe oryzae (anamorph Pyricularia oryzae) is the causal agent of blast disease of Poaceae crops and their wild relatives. To understand the genetic mechanisms that drive host specialization of M. oryzae, we carried out whole genome resequencing of four M. oryzae isolates from rice (Oryza sativa), one ...

journal_title：BMC genomics

authors： Yoshida K,Saunders DG,Mitsuoka C,Natsume S,Kosugi S,Saitoh H,Inoue Y,Chuma I,Tosa Y,Cano LM,Kamoun S,Terauchi R

更新日期：2016-05-18 00:00:00

abstract：BACKGROUND:Glandular trichomes produce a wide variety of commercially important secondary metabolites in many plant species. The most prominent anti-malarial drug artemisinin, a sesquiterpene lactone, is produced in glandular trichomes of Artemisia annua. However, only limited genomic information is currently available...

journal_title：BMC genomics

authors： Wang W,Wang Y,Zhang Q,Qi Y,Guo D

更新日期：2009-10-09 00:00:00

abstract：BACKGROUND:Campylobacter is the leading cause of foodborne diarrhoeal illness in humans and is mostly acquired from consumption or handling of contaminated poultry meat. In the absence of effective licensed vaccines and inhibitors, selection for chickens with increased resistance to Campylobacter could potentially redu...

journal_title：BMC genomics

authors： Psifidi A,Fife M,Howell J,Matika O,van Diemen PM,Kuo R,Smith J,Hocking PM,Salmon N,Jones MA,Hume DA,Banos G,Stevens MP,Kaiser P

更新日期：2016-04-18 00:00:00

abstract：BACKGROUND:Chloroplasts have their own genomes, independent from nuclear genomes, that play vital roles in growth, which is a major targeted trait for genetic improvement in Populus. Angiosperm chloroplast genomes are maternally inherited, but the chloroplast' variation pattern of poplar at the single-base level during...

journal_title：BMC genomics

authors： Zhu S,Xu M,Wang H,Pan H,Wang G,Huang M

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:Understanding the basis for volatile organic compound (VOC) biosynthesis and regulation is of great importance for the genetic improvement of fruit flavor. Lactones constitute an essential group of fatty acid-derived VOCs conferring peach-like aroma to a number of fruits including peach, plum, pineapple and ...

journal_title：BMC genomics

authors： Sánchez-Sevilla JF,Cruz-Rus E,Valpuesta V,Botella MA,Amaya I

更新日期：2014-04-17 00:00:00

abstract：BACKGROUND:The mosquito Anopheles gambiae is a major vector of human malaria. Increasing evidence indicates that blood cells (hemocytes) comprise an essential arm of the mosquito innate immune response against both bacteria and malaria parasites. To further characterize the role of hemocytes in mosquito immunity, we un...

journal_title：BMC genomics

authors： Baton LA,Robertson A,Warr E,Strand MR,Dimopoulos G

更新日期：2009-06-05 00:00:00

abstract：BACKGROUND:High throughput genotyping of single nucleotide polymorphisms (SNPs) for genome-wide association requires technologies for generating millions of genotypes with relative ease but also at a reasonable cost and with high accuracy. In this work, we have developed a theoretical approach to estimate allele freque...

journal_title：BMC genomics

authors： Yin BC,Li H,Ye BC

更新日期：2008-12-16 00:00:00

abstract：BACKGROUND:Among viruses, bacteriophages are a group of special interest due to their capacity of infecting bacteria that are important for biotechnology and human health. Composting is a microbial-driven process in which complex organic matter is converted into humus-like substances. In thermophilic composting, the de...

journal_title：BMC genomics

authors： Amgarten D,Martins LF,Lombardi KC,Antunes LP,de Souza APS,Nicastro GG,Kitajima EW,Quaggio RB,Upton C,Setubal JC,da Silva AM

更新日期：2017-05-04 00:00:00

abstract：BACKGROUND:It is generally agreed that horizontal gene transfer (HGT) is common in phagotrophic protists. However, the overall scale of HGT and the cumulative impact of acquired genes on the evolution of these organisms remain largely unknown. RESULTS:Choanoflagellates are phagotrophs and the closest living relatives ...

journal_title：BMC genomics

authors： Yue J,Sun G,Hu X,Huang J

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Wine produced at low temperature is often considered to improve sensory qualities. However, there are certain drawbacks to low temperature fermentations: e.g. low growth rate, long lag phase, and sluggish or stuck fermentations. Selection and development of new Saccharomyces cerevisiae strains well adapted a...

journal_title：BMC genomics

authors： López-Malo M,García-Rios E,Melgar B,Sanchez MR,Dunham MJ,Guillamón JM

更新日期：2015-07-22 00:00:00

abstract：BACKGROUND:Shotgun sequencing of environmental DNA is an essential technique for characterizing uncultivated microbes in situ. However, the taxonomic and functional assignment of the obtained sequence fragments remains a pressing problem. RESULTS:Existing algorithms are largely optimized for speed and coverage; in con...

journal_title：BMC genomics

authors： Stark M,Berger SA,Stamatakis A,von Mering C

更新日期：2010-08-05 00:00:00

abstract：BACKGROUND:Rhesus macaques serve a critical role in the study of human biomedical research. While both Indian and Chinese rhesus macaques are commonly used, genetic differences between these two subspecies affect aspects of their behavior and physiology, including response to simian immunodeficiency virus (SIV) infecti...

journal_title：BMC genomics

authors： Ferguson B,Street SL,Wright H,Pearson C,Jia Y,Thompson SL,Allibone P,Dubay CJ,Spindel E,Norgren RB Jr

更新日期：2007-02-07 00:00:00

abstract：BACKGROUND:Protein-protein interaction (PPI) maps are useful tools for investigating the cellular functions of genes. Thus far, large-scale PPI mapping projects have not been implemented for the rice blast fungus Magnaporthe grisea, which is responsible for the most severe rice disease. Inspired by recent advances in P...

journal_title：BMC genomics

authors： He F,Zhang Y,Chen H,Zhang Z,Peng YL

更新日期：2008-11-02 00:00:00

abstract：BACKGROUND:At sexual maturity, the liver of laying hens undergoes many metabolic changes to support vitellogenesis. In published transcriptomic approaches, hundreds of genes were reported to be overexpressed in laying hens and functional gene annotation using gene ontology tools have essentially revealed an enrichment ...

journal_title：BMC genomics

authors： Gloux A,Duclos MJ,Brionne A,Bourin M,Nys Y,Réhault-Godbert S

更新日期：2019-11-07 00:00:00

abstract：BACKGROUND:Despite significant efforts from the research community, an extensive portion of the proteins encoded by human genes lack an assigned cellular function. Most metazoan proteins are composed of structural and/or functional domains, of which many appear in multiple proteins. Once a domain is characterized in on...

journal_title：BMC genomics

authors： Kemmer D,Podowski RM,Arenillas D,Lim J,Hodges E,Roth P,Sonnhammer EL,Höög C,Wasserman WW

更新日期：2006-03-13 00:00:00

abstract：BACKGROUND:Simple Sequence Repeats (SSRs) are widely used in population genetic studies but their classical development is costly and time-consuming. The ever-increasing available DNA datasets generated by high-throughput techniques offer an inexpensive alternative for SSRs discovery. Expressed Sequence Tags (ESTs) hav...

journal_title：BMC genomics

authors： Lopez L,Barreiro R,Fischer M,Koch MA

更新日期：2015-10-13 00:00:00

abstract：BACKGROUND:Research using the model system Xenopus laevis has provided critical insights into the mechanisms of early vertebrate development and cell biology. Large scale sequencing efforts have provided an increasingly important resource for researchers. To provide full advantage of the available sequence, we have ana...

journal_title：BMC genomics

authors： Sczyrba A,Beckstette M,Brivanlou AH,Giegerich R,Altmann CR

更新日期：2005-09-14 00:00:00