Dynamic modeling of in vitro lipid digestion: individual fatty acid release and bioaccessibility kinetics.

Abstract:

:The aim of this study was to gain knowledge about the role of triacylglycerol (TAG) composition in fatty acids (FA) of o/w emulsions on both the pancreatic lipolysis kinetics and the bioaccessibility of released products (i.e. contained within the bile salt micellar phase). A mathematical model was developed and its predictions were compared to a set of experimental data obtained during an in vitro digestion of a whey protein stabilized emulsion. Modeling results show that FA residues of TAG were hydrolyzed at specific rates, inducing different bioaccessibility kinetics. The estimated lipolysis rate constants of the studied FA (C8:0, C10:0≫C18:1 n-9≫C12:0>C14:0>C16:0≈C16:1 n-7>C22:6 n-3) were in close agreement with the available literature on the substrate specificity of pancreatic lipase. Results also suggest that lipolysis products are very rapidly solubilized in the bile salt mixed micelles with no fractionation according to the FA carbon chain.

journal_name

Food Chem

journal_title

Food chemistry

authors

Giang TM,Gaucel S,Brestaz P,Anton M,Meynier A,Trelea IC,Le Feunteun S

doi

10.1016/j.foodchem.2015.08.125

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

1180-8

eissn

0308-8146

issn

1873-7072

pii

S0308-8146(15)01334-5

journal_volume

194

pub_type

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