Abstract：
:The mechanical resistance of the stratum corneum, the outermost layer of skin, to deformation has been evaluated at different length scales using Atomic Force Microscopy. Nanomechanical surface mapping was first conducted using a sharp silicon tip and revealed that Young׳s modulus of the stratum corneum varied over the surface with a mean value of about 0.4GPa. Force indentation measurements showed permanent deformation of the skin surface only at high applied loads (above 4µN). The latter effect was further demonstrated using nanomechanical imaging in which the obtained depth profiles clearly illustrate the effects of increased normal force on the elastic/plastic surface deformation. Force measurements utilizing the single hair fiber probe supported the nanoindentation results of the stratum corneum being highly elastic at the nanoscale, but revealed that the lateral scale of the deformation determines the effective elastic modulus.This result resolves the fact that the reported values in the literature vary greatly and will help to understand the biophysics of the interaction of razor cut hairs that curl back during growth and interact with the skin.
journal_name
J Mech Behav Biomed Materauthors
Álvarez-Asencio R,Wallqvist V,Kjellin M,Rutland MW,Camacho A,Nordgren N,Luengo GSdoi
10.1016/j.jmbbm.2015.09.014subject
Has Abstractpub_date
2016-02-01 00:00:00pages
185-93eissn
1751-6161issn
1878-0180pii
S1751-6161(15)00350-1journal_volume
54pub_type
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