Abstract：
:Two new glucosides (1 and 2) of geldanamycin (GA) analogs were obtained from in vitro glycosylation by UDP-glycosyltransferase (YjiC). Based on spectroscopic (HR-ESI-MS, 1D, and 2D-NMR) analyses, the glucosides were elucidated as 4,5-dihydro-7-O-descarbamoyl-7- hydroxyl GA-7-O-β-D-glucoside (1) and ACDL3172-18-O-β-D-glucoside (2). Furthermore, the water solubility of compounds 1 and 2 was about 215.2 and 90.7 times higher respectively, than that of the substrates. Among compounds 1-4, only 3 showed weak antiproliferative activity against four human tumor cell lines: MDA-MB-231, SMMC7721, HepG2, and SW480 (IC50: 13.6, 15.1, 31.8, and 22.7 micrometer, respectively).
journal_name
J Microbiol Biotechnoljournal_title
Journal of microbiology and biotechnologyauthors
Huo Q,Li HM,Lee JK,Li J,Ma T,Zhang X,Dai Y,Hong YS,Wu CZdoi
10.4014/jmb.1508.08069subject
Has Abstractpub_date
2016-01-01 00:00:00pages
56-60issue
1eissn
1017-7825issn
1738-8872pii
10.4014/jmb.1508.08069journal_volume
26pub_type
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