Abstract：
:In the present study, the adhesion of bacteriocin-producing probiotic strains of Lactobacillus plantarum onto extracellular matrix (ECM) proteins such as collagen and mucin and their potential to prevent pathogen invasion onto the ECM was ascertained. Fluorescence-based in vitro assays indicated that L. plantarum strains CRA21, CRA38 and CRA52 displayed considerable adhesion to ECM molecules, which was comparable to the probiotic Lactobacillus rhamnosus GG. Flow cytometry-based quantitative assessment of the adhesion potential suggested that L. plantarum CRA21 exhibited superior adhesion onto the ECM as compared with other lactic acid bacteria strains. Furthermore, fluorescence-based assays suggested that the highest inhibition of Staphylococcus aureus adhesion onto collagen and mucin by bacteriocin-producing L. plantarum strains was observed in the exclusion mode as compared with the competition and displacement modes. This observation was supported by the higher binding affinity (k(d)) for the ECM exhibited by the L. plantarum strains as compared with S. aureus. Interestingly, a crude plantaricin A extract from food isolates of L. plantarum displayed potent antibacterial activity on ECM-adhered S. aureus cells. It is envisaged that the L. plantarum isolates displaying bacteriocinogenic and ECM-adhering traits can perhaps be explored to develop safe antibacterial therapeutic agents.
journal_name
J Med Microbioljournal_title
Journal of medical microbiologyauthors
Mukherjee S,Ramesh Adoi
10.1099/jmm.0.000181subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1514-1526issue
12eissn
0022-2615issn
1473-5644journal_volume
64pub_type
杂志文章abstract：:In order to develop a model for the study of gastric spiral bacteria, and based on the observation that Wistar rats do not carry urease-positive spiral bacteria in their gastric mucosa, mucus from a pig naturally colonised by 'Gastrospirillum suis' (an organism with I6S rDNA 99.5% similar to that of 'G. hominis' type ...
journal_title：Journal of medical microbiology
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abstract：:Hepatitis E virus (HEV) is an RNA virus that is an important cause of both acute and chronic hepatitis worldwide. To date, there are eight HEV genotypes that can infect mammals. HEV-1 and HEV-2 infect exclusively humans, while HEV-3 and HEV-4 infect humans and various animals, mainly pigs and deer. Additionally, two n...
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journal_title：Journal of medical microbiology
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doi：10.1099/jmm.0.075044-0
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pub_type： 杂志文章,评审
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journal_title：Journal of medical microbiology
pub_type： 杂志文章,评审
doi：10.1099/jmm.0.004465-0
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doi：10.1099/00222615-22-1-51
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更新日期：2013-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1099/00222615-11-3-325
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journal_title：Journal of medical microbiology
pub_type： 杂志文章
doi：10.1099/00222615-16-1-13
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doi：10.1099/jmm.0.000533
更新日期：2017-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1099/jmm.0.036103-0
更新日期：2011-12-01 00:00:00
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journal_title：Journal of medical microbiology
pub_type： 杂志文章
doi：10.1099/00222615-26-1-19
更新日期：1988-05-01 00:00:00
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doi：10.1099/jmm.0.47660-0
更新日期：2008-03-01 00:00:00
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更新日期：2013-05-01 00:00:00
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更新日期：2008-12-01 00:00:00
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更新日期：2017-11-01 00:00:00
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journal_title：Journal of medical microbiology
pub_type： 杂志文章
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更新日期：2010-10-01 00:00:00
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journal_title：Journal of medical microbiology
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更新日期：1996-07-01 00:00:00
