Abstract:
BACKGROUND:The purpose of this study was to investigate the association between Trp719Arg (rs20455) and Coronary Heart Disease (CHD), and also Coronary Heart Disease reduction in individuals with this SNP during statin therapy in southern Iran. It has been shown that rs20455, which could affect the function of kinesin protein, is associated with Coronary Heart Disease and could be an effective factor for patients who take statin therapy. METHODS:Patients and control individuals were genotyped for rs20455 Single Nucleotide Polymorphism (SNP) using ARMS PCR (Amplification Refractory Mutation System Polymerase Chain Reaction) and RFLP (Restriction Fragment Length Polymorphism) analysis. The effect of kinesin family member 6 (KIF6) on statin therapy was also examined among patients who had a history of one or two heart attacks. RESULTS:It was found that rs20455 had a significant association with Coronary Heart Disease (Odds Ratio [OR] 3.17, 95% Confidence Interval [CI] 1.68 to 5.98). In addition, statin therapy was more effective in rs20455 carriers than non-carriers, with 80% of the carriers showed positive response to this treatment. CONCLUSIONS:Trp 719Arg have an effect on development of Coronary Heart Disease but it is very useful for statin therapy. Overall, individuals with this Single Nucleotide Polymorphism can take statin therapy to prevent the catastrophic consequences of Coronary Heart Disease.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Hamidizadeh L,Haji Hosseini Baghdad Abadi R,Babaee Baigi MA,Dastsooz H,Khazaei Nejhad A,Fardaei Mdoi
0151810/AIM.008subject
Has Abstractpub_date
2015-10-01 00:00:00pages
683-7issue
10eissn
1029-2977issn
1735-3947pii
008journal_volume
18pub_type
杂志文章abstract::Acute hemorrhagic edema of infancy is a distinctive, cutaneous small vessel leukocytoclastic vasculitis of young children with dramatic characteristic skin findings. It is characterized by low- grade fever, erythematous edema, and purpuric lesions mainly on the face and extremities. Visceral involvement is uncommon, a...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:08111/AIM.0019
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Our aim was to determine the association between age at menarche (AAM) and breast cancer adjusted for recall bias (misclassification) in AAM. METHODS:We have used data provided from a case-control study conducted in Iran from 2005 to 2009. The cases and controls were frequency matched based on 5-year age gr...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:The present study reported a six-year follow up of patients with chronic myeloid leukemia who were on imatinib therapy. METHODS:We performed a retrospective study on a total of 417 patients diagnosed with chronic-phase, Philadelphia-positive (Ph+) chronic myeloid leukemia within six months before study entr...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:011146/AIM.004
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Many risk factors have been investigated in multiple sclerosis (MS); however, few studies have focused on the association between risk factors and the disease severity. The aim of our study was to evaluate the association between some of these risk factors and MS severity in a population sample of Iranian pa...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0161912/AIM.007
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Mucocutaneous candidiasis (almost endogenous) is one of the most common manifestations of human immunodeficiency virus (HIV) infection. The aim of this study was the investigation of colonization patterns of Candida species, particularly C. dubliniensis, among mucosal sites of HIV-positive patients and deter...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:010134/AIM.006
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Wrong beliefs about risky actions such as sunbathing and tanning are common due to media advertisements or general lack of knowledge. This work has focused on the knowledge and attitude of a group of citizens in Tehran, Iran and the protective actions they take regarding undesirable effects of the sun. M...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:011142/AIM.0011
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is a major health problem in many developing countries including Iran. ESCC has a very poor prognosis, largely due to late diagnosis. As a first step in developing an early detection and treatment program, we conducted a population-based endoscopic screening for ESCC...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:014174/AIM.006
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The threshold of thyroid-stimulating hormone (TSH) in current screening for congenital hypothyroidism (CH) from the heel prick test is 5 mU/l. This study uses cost-effective analysis to evaluate increasing the threshold to minimize false-positive results and recall rates. METHODS:Cost of screening, diagnosi...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:012153/AIM.006
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Sleep disturbances are common among adult populations and can have a significant effect on daytime activities. The aim of this study is to determine the prevalence of sleep problems and subjective sleep quality in the adult population of Tehran, Iran. METHODS:From an urban community of Tehran, a random samp...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:012152/AIM.0010
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Non-invasive ventilation (NIV) has brought about a significant change in care and treatment of respiratory distress syndrome (RDS) in very low birth weight (VLBW) neonates. The present study was designed and conducted to evaluate different strategies of initial respiratory support (IRS) in VLBW neonates hosp...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0172003/AIM.008
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:In recent years the increasing use of nanoparticles has led researchers to study their effects on biological systems. The most important effects of nanoparticles on cells are their ability to induce or suppress production of reactive oxygen species (ROS). Changes in reactive oxygen species play an important ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0151809/AIM.008
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:The childhood obesity epidemic is one of the most serious global health challenges, and many relevant policies have been designed and implemented. Regarding health equity policy-making, it is important to adopt proper interventional strategies, including childhood obesity policies. The purpose of this study ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Growth is an increase in the physical dimensions and its result is a quantitative change in the body. Development is a progressive increase in the skills and functional capacity of a child and its result is a qualitative change in a child's function. METHODS:This investigation was a descriptive, decompositi...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Venous thromboembolism refers to thrombotic events in the venous system that are most commonly manifested as deep vein thromboses in the upper or lower extremity and/or pulmonary embolism. Venous thromboembolism is a common disorder that is associated with significant mortality, morbidity and health care-related cost....
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,评审
doi:
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Little is known about the degree of utilization of information resources on diabetes by general practitioners (GPs) and its impact on their clinical behavior in developing countries. Such information is vital if GPs' diabetes knowledge is to be improved. METHODS:This cross-sectional study recruited 319 GPs ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:012154/AIM.0010
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:The current study aimed to evaluate the mechanisms involved in protection against doxorubicin-induced cardiac and renal toxicities upon treatment with eicosapentaenoic acid and vitamin E. METHODS:Rats were randomly assigned to 4 groups: normal control, doxorubicin inducted control, eicosapentaenoic acid tre...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Non-antifungal drugs appear promising in treatment of opportunistic infections of Candida spp. that are often resistant to current antifungals. METHODS:The broth macrodilution method (NCCLS M27-P document) was used to compare the antifungal activity of trifluoperazine, propranolol, and lansoprazole with tha...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:012151/AIM.009
更新日期:2012-01-01 00:00:00
abstract::Heterotopic neuroglial tissue, composed of differentiated neuroectodermal tissue, represents developmental heterotopia of neuroglial tissue rather than true neoplasm. Herein, we present a patient with nasopharyngeal heterotopic neuroglial tissue who presented with respiratory distress and feeding difficulty in early d...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:We aimed to assess the results of first- and fifth-year outcomes and the effect on quality of life (QoL) of transobturator tape (TOT) treatment in patients with stress urinary incontinence (SUI). METHODS:The patients who underwent TOT surgery between January 2008 and June 2013 were screened retrospectively....
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:10.34172/aim.2020.110
更新日期:2020-12-01 00:00:00
abstract::Longitudinal studies are very common in medical, behavioral, and interventional sciences. One measure of effect of interest in longitudinal studies is risk ratio, naturally estimated by log-binomial regression which suffers from convergence problem. Odds ratio does not well approximate risk ratio when the outcome is c...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:(125)I is one of the important sources frequently used in brachytherapy. Up to now, several different commercial models of this source type have been introduced to the clinical radiation oncology applications. Recently, a new source model, IrSeed-125, has been added to this list. The aim of the present study...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0161903/AIM.006
更新日期:2016-03-01 00:00:00
abstract::Head injury is a common occurrence in motor vehicle accidents. There are numerous causes for cranial nerve injury that include head trauma or other lesions. Few studies regarding cranial nerve injury following mild head trauma (GCS: 14 - 15) exist in the literature. The oculomotor nerve is a somatic and visceral motor...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:012159/AIM.0015
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Oxidative stress is involved in the pathophysiology of diabetes mellitus. METHODS:In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically healthy individuals were evaluated. The patients were divided into two groups. Group 1 included 29 patients without diabetic complications and g...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:There is a lack of data regarding the incidence rate, etiology, risk factors, and natural course of thyroid disorders and their relationship with cardiovascular disease and mortality in populations undergoing nutrition transition. Therefore, we aimed to assess the natural course of thyroid disease in Tehrani...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:013167/AIM.0011
更新日期:2013-07-01 00:00:00
abstract::Primary glomus tumors are extremely rare in the liver. To this date, only two cases of primary glomus tumors of the liver have been reported in the literature. This report is the third case of this specified tumor. The patient was a 50 year-old Iranian woman who presented with a history of epigastric pain and nausea. ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0011144/AIM.0015
更新日期:2011-07-01 00:00:00
abstract::This brief review presents Razi's concepts of bone and joint disorders. Razi differentiated between ligaments, tendons, and nerves and recognized the role of the brain, spinal cord, and peripheral nervous system in the perception of senses and voluntary movements. He described paralysis and loss of sensation following...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:10.34172/aim.2020.74
更新日期:2020-09-01 00:00:00
abstract::This paper presents a systematic literature review of studies that shed light on the health of migrants in Iran from the perspective of social justice. A systematic search was conducted in PubMed and Iranian databases, including IranMedex, Magiran, and SID, in June 2012. All studies that were published until June 2012...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,评审
doi:0161910/AIM.0012
更新日期:2016-10-01 00:00:00
abstract:INTRODUCTION:Lynch Syndrome (LS) is a genetically inherited autosomal disorder that increases the risk of many types of cancer, especially colorectal cancer (CRC). Identifying these subjects improves morbidity and mortality. We aimed to assess the prevalence of LS with both clinical criteria and universal strategy in M...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,多中心研究
doi:0172006/AIM.003
更新日期:2017-06-01 00:00:00
abstract::Intravenous drug abuse is an increasing social and health problem. Repeated injuries to the veins, injection of some types of insoluble substances, and needle sharing habits result in various complications. Increasing incidence of major vascular complications has been reported worldwide. The objective of this study wa...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:07104/AIM.0018
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Polycystic ovary syndrome is not uncommon in women of reproductive age. We conducted this study to determine the clinical, hormonal, and biochemical effects of metformin therapy on girls with polycystic ovary syndrome. METHODS:In a self-controlled clinical trial conducted at the Gynecology Center of Yahyane...
journal_title:Archives of Iranian medicine
pub_type: 临床试验,杂志文章
doi:07102/AIM.0010
更新日期:2007-04-01 00:00:00