Abstract:
BACKGROUND/AIMS:Rats with a spontaneous null mutation in endothelin receptor type B or Ednrb (sl/sl; spotting lethal) lack enteric neurons in the distal bowel and usually die within the first week after birth. This early postnatal lethality limits their use for examining the potential of cell therapy to treat Hirschsprung disease, and for studies of the influence of EDNRB on the mature CNS and vascular systems. METHODS:We have developed a surgical intervention to prolong the life of the spotting lethal sl/sl rat, in which we perform a colostomy on postnatal (P) day 4-6 rats to avoid the fatal obstruction caused by the lack of colonic enteric neurons. RESULTS:The stomas remained patent and functional and the rats matured normally following surgery. Weight gains were comparable between control and Hirschsprung phenotype (sl/sl) rats, which were followed until 4 weeks after surgery (5 weeks old). We confirmed the absence of enteric neurons in the distal colon of rats whose lives were saved by the surgical intervention. CONCLUSIONS:This study provides a novel approach for studying EDNRB signalling in multiple organ systems in mature rats, including an animal model to study the efficacy of cell therapy to treat Hirschsprung disease.
journal_name
J Neurogastroenterol Motiljournal_title
Journal of neurogastroenterology and motilityauthors
Stamp LA,Obermayr F,Pontell L,Young HM,Xie D,Croaker DH,Song ZM,Furness JBdoi
10.5056/jnm15079subject
Has Abstractpub_date
2015-10-01 00:00:00pages
552-9issue
4eissn
2093-0879issn
2093-0887pii
jnm15079journal_volume
21pub_type
杂志文章abstract:BACKGROUND/AIMS:While it is well established that acupuncture relieves somatic pain, its therapeutic effect on visceral pain such as irritable bowel syndrome (IBS) is unclear. We evaluated the effect of acupuncture in treating visceral hyperalgesia in an animal model. METHODS:Sprague-Dawley rats (n = 8 per group) with...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2010.16.3.306
更新日期:2010-07-01 00:00:00
abstract::Patients with dyspepsia/functional dyspepsia (FD) show frequent overlapping of other gastrointestinal (GI) diseases, such as irri-table bowel syndrome, and non-GI diseases, in addition to internal subgroup overlapping. These overlap patients have more frequent or more severe symptoms, poorer health-related quality of ...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm14080
更新日期:2014-10-30 00:00:00
abstract:Background/Aims:High-resolution manometry (HRM) has broadened the awareness of minor esophageal peristaltic disorders. However, the treatments for these minor disorders are limited and the role of prokinetics has been controversial. This study evaluates the effect of mosapride in patients with minor peristaltic disorde...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm19062
更新日期:2020-04-30 00:00:00
abstract::Assessment of transit through the gastrointestinal tract provides useful information regarding gut physiology and patho-physiology. Although several methods are available, each has distinct advantages and limitations. Recently, an ingestible wire-less motility capsule (WMC), similar to capsule video endoscopy, has bec...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2014.20.2.265
更新日期:2014-04-30 00:00:00
abstract:Background/Aims:Integrated relaxation pressure (IRP) is defined as the average minimum esophagogastric junction (EGJ) pressure for 4 seconds of relaxation (contiguous or noncontiguous) within 10 seconds of swallowing. The durability of IRP values during successive swallows in the supine position remains to be elucidate...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm20139
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND/AIMS:To draw a normative database of laryngopharynx pH profile in Chinese subjects. METHODS:Normal volunteers were recruited from "www.Ganji.com" and People's hospital between May 2008 and December 2009. The Restech pH Probes were calibrated in pH 7 and pH 4 buffer solutions according to the manufacturer's ...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm13138
更新日期:2014-07-31 00:00:00
abstract::Cyclic vomiting syndrome (CVS) is a disorder characterized by recurrent episodes of incapacitating nausea and vomiting interspersed with symptom free periods. Common triggers of cyclic vomiting include noxious stress, excitement, fatigue and menstrual period. Here, we report a case of cyclic vomiting syndrome in adult...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2010.16.1.77
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND/AIMS:Solifenacin, a muscarinic type 3 receptor antagonist, is used to treat overactive bladder in adults. The aim of this study is to examine the efficacy of solifenacin on the symptomatic relief of diarrhea predominant irritable bowel syndrome (IBS-D). METHODS:A total of 20 patients with IBS-D were enrolle...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2012.18.3.317
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND/AIMS:Recent studies reveal that acute gastroenteritis can precipitate irritable bowel syndrome (IBS) symptoms leading to the concept of post-infectious IBS. However, the overall contribution of gastroenteritis to the total IBS prevalence is unknown. In this exercise we try to estimate the contribution of gas...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2012.18.2.200
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND/AIMS:Functional gastrointestinal disorders (FGIDs), diagnosed by symptom-based criteria due to lack of biomarkers, need translatedvalidated questionnaires in different languages. As Bengali, the mother tongue of Bangladesh and eastern India, is the seventh most spoken language in the world, we translated and...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm15129
更新日期:2016-04-30 00:00:00
abstract:Background/Aims:The prevalence of eosinophilic esophagitis (EoE) is reportedly increasing in Western countries. However, its prevalence in Korea remains unknown. We investigated the diagnostic trends and clinical characteristics of EoE in Korea. Methods:Using an endoscopic database maintained at a tertiary care center...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm17047
更新日期:2018-04-30 00:00:00
abstract:Background/Aims:Currently, there exists no biomarker for visceral hypersensitivity in irritable bowel syndrome (IBS). Piezo proteins have been proven to play an important role in the mechanical stimulation to induce visceral pain in other tissues and may also be a biomarker candidate. The aim of this study was to test ...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm16114
更新日期:2017-07-30 00:00:00
abstract:Background/Aims:Current evidence suggests the presence of motility or functional abnormalities in one area of the gastrointestinal tract increases the likelihood of abnormalities in others. However, the relationship of gastroparesis to chronic constipation (slow transit constipation and dyssynergic defecation) has been...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm18206
更新日期:2019-04-30 00:00:00
abstract::An increase in intracellular Ca(2+) is the primary trigger of contraction of gastrointestinal (GI) smooth muscles. However, increasing the Ca(2+) sensitivity of the myofilaments by elevating myosin light chain phosphorylation also plays an essential role. Inhibiting myosin light chain phosphatase activity with protein...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章,评审
doi:10.5056/jnm15186
更新日期:2016-04-30 00:00:00
abstract:BACKGROUND/AIMS:Researches on the potential risk factors for the development of erosive esophagitis have been conducted extensively, however, the results are conflicting. The aim of this multicenter study was to identify the prevalence rate and risk factors of erosive esophagitis and their interactions with residency s...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2013.19.1.70
更新日期:2013-01-01 00:00:00
abstract:Background/Aims:Recent studies suggest that air pollution may play a role in gastrointestinal disorders. However, the effect of long-term exposure to air pollution on childhood irritable bowel syndrome (IBS) is unclear. Hence, we conducted a nationwide cohort study to investigate the association between long-term air p...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm18135
更新日期:2019-04-30 00:00:00
abstract:BACKGROUND/AIMS:Transient lower esophageal sphincter relaxation (TLESR) is the main mechanism of gastroesophageal reflux disease (GERD). The aim of this study was to investigate the characteristics of transient lower esophageal sphincter movement in patients with or without gastroesophageal reflux by high-resolution ma...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2013.19.3.332
更新日期:2013-07-01 00:00:00
abstract::Visceral pain is the most common form of pain caused by varied diseases and a major reason for patients to seek medical consultation. It also leads to a significant economic burden due to workdays lost and reduced productivity. Further, long-term use of non-specific medications is also associated with side effects aff...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm15026
更新日期:2015-03-30 00:00:00
abstract:BACKGROUND/AIMS:Proton pump inhibitors (PPIs) which are the most effective agents for the treatment of gastroesophageal reflux disease (GERD), have been known to delay gastric emptying. Mosapride has been used as prokinetics by accelerating gastric emptying. We evaluated the efficacy of mosapride to prevent PPI-induced...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2013.19.4.495
更新日期:2013-10-01 00:00:00
abstract:Background/Aims:Since the use of dexlansoprazole in Asian subjects with gastroesophageal reflux disease (GERD) has not been adequately characterized, this study was conducted to evaluate the efficacy and safety of dexlansoprazole modified-release in Asian subjects with non-erosive reflux disease (NERD) and erosive esop...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm19031
更新日期:2020-01-30 00:00:00
abstract::Irritable bowel syndrome (IBS) has been one of the commonly presented gastrointestinal disorders. It is of interest how commonly it presents in the society. Western studies indicated that most population-based IBS prevalences range 10%-15%. It is believed that IBS is prevalent in both East and West countries without a...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2010.16.4.389
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND/AIMS:To evaluate the effects of the phosphodiesterase type 5 (PDE5) inhibitor vardenafil on esophageal function, including bolus transit, using multichannel intraluminal impedance and esophageal manometry (MII-EM). METHODS:Sixteen healthy volunteers (15 men) underwent an MII-EM study including 10 liquid swa...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2012.18.4.399
更新日期:2012-10-01 00:00:00
abstract::In predisposed individuals with long standing gastroesophageal reflux disease (GERD), esophageal squamous mucosa can transform into columnar mucosa with intestinal metaplasia, commonly called Barrett's esophagus (BE). Barrett's mucosa can develop dysplasia, which can be a precursor for esophageal adenocarcinoma (EAC)....
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm18156
更新日期:2019-04-30 00:00:00
abstract:Background/Aims:Lipopolysaccharide (LPS) is the key factor inducing mucosal and systemic inflammation in various intestinal and parenteral diseases, which could initially disrupt the epithelial barrier function. EphrinA1/ephA2 is speculated to increase the epithelial permeability for its "repulsive interaction" between...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm19095
更新日期:2020-07-30 00:00:00
abstract:Background/Aims:The prevalence and severity of irritable bowel syndrome (IBS) declines with age, but the cause of this is unknown. This study tested 2 hypotheses: (1) autonomic nervous system responses to eating and bowel distention, measured by heart rate variability (HRV), differs by age in IBS patients and (2) HRV i...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm16216
更新日期:2018-01-30 00:00:00
abstract:BACKGROUND/AIMS:In isolated guinea-pig colon, we investigated regional differences in peristalsis evoked by intrinsic electrical nerve stimulation. METHODS:Four colonic segments from mid and distal colon of Hartley guinea pigs, were mounted horizontally in an organ bath. Measurement of pellet propulsion time, intralum...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2013.19.2.192
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND/AIMS:Gastroparesis-like syndrome (GLS) is defined as gastroparesis-like symptoms with normal gastric scintigraphy. While the efficacy of gastric electrical stimulation (GES) in gastroparesis is well known, the utility of GES in GLS is largely unknown. Our aim was to clarify the role of GES in GLS. We implant...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm15046
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND/AIMS:Rome criteria classifying functional gastrointestinal disorder (FGID) were updated. The aims of this study were to assess the spectra of FGID and to evaluate the applicability of Rome III criteria in Korea. METHODS:New patients who visited 2 primary clinics and 2 tertiary care hospitals were consecutiv...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2011.17.3.279
更新日期:2011-07-01 00:00:00
abstract::Radiofrequency catheter ablation (RFCA) is a potentially curative method for treatment of highly symptomatic and drug-refractory atrial fibrillation (AF). However, this technique can provoke esophageal and nerve lesion, due to thermal injury. To our knowledge, there have been no reported cases of a newly described mot...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm15034
更新日期:2015-10-01 00:00:00
abstract:Background/Aims:The Gastroesophageal Reflux Disease Questionnaire (GerdQ) has been developed and validated as a tool for the diagnosis of gastroesophageal reflux disease (GERD) in patients with gastrointestinal symptoms. However, the GerdQ and the cutoff value for determining GERD has not been validated in Korea. Meth...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm18133
更新日期:2019-01-31 00:00:00