Abstract:
BACKGROUND:Acinetobacter baumannii has emerged as an important nosocomial pathogen. Hospital outbreaks of extensively drug resistant (XDR) A. baumannii are a great concern. OBJECTIVES:Aims of this study were to characterize the resistance determinants and genetic relatedness of (XDR) A. baumannii isolates in hospitals in Tehran, Iran. MATERIALS AND METHODS:During a three-year study, clinical isolates of A. baumannii were collected from two hospitals in Tehran, Iran. Susceptibility testing to antibiotics was performed by disk diffusion method and XDR A. baumannii isolates were identified. Genes' encoding for carbapenemase production and integrons were identified by PCR. MICs of imipenem and meropenem were determined by agar dilution. Multiple locus variable-number tandem repeat analysis (MLVA) typing was used to determine genetic relationships of XDR isolates. RESULTS:Using PCR for amplification of bla OXA-51 , 93.9% (123.131) of isolates were identified as A. baumannii and 24.4% (30.123) were XDR. These isolates were resistant to gentamicin, ciprofloxacin, amikacin, cotrimoxazole, cefepime, cefotaxime, aztreonam and ceftazidime. Thirty percent of the isolates were resistant to tigecycline. All isolates were susceptible to colistin and polymyxin-B, while 93.3% (28.30) possessed bla OXA-23 -like and 6.7% (2.30) possessed bla OXA-24 -like. All isolates possessed insertion sequence (ISAba1) in the upstream region of the OXA-23-like gene. Almost 96.7% (29.30) of the isolates were positive for class I integron and 43.3% (13.30) for class II. These isolates were also positive for class I. Class III integron was not detected. MLVA typing of XDR isolates showed seven clonally complexes and 16 singletons. CONCLUSIONS:The population structure of the A. baumannii isolates in our hospitals was genetically diverse. A significant association between XDR pattern and presence of class 1 integron (P < 0.001) was found indicating that many antibiotic resistance determinants are involved in development of XDR strains.
journal_name
Jundishapur J Microbioljournal_title
Jundishapur journal of microbiologyauthors
Najar Peerayeh S,Karmostaji Adoi
10.5812/jjm.27021v2subject
Has Abstractpub_date
2015-07-25 00:00:00pages
e27021issue
7eissn
2008-3645issn
2008-4161journal_volume
8pub_type
杂志文章abstract:BACKGROUND:Poly 3-Hydroxybutyrate (PHB), a class of Poly Hydroxyalkanoates (PHAs), is a group of bacterial storage polymers, produced by various microorganisms in response to nutrient limitation. PHAs are biodegradable polymers which could be a good substitute for current petrochemical plastics. PHB has been synthesize...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.16318
更新日期:2015-02-20 00:00:00
abstract:BACKGROUND:Drug design against human immunodeficiency virus type 1 (HIV-1) integrase through its mechanistic study is of great interest in the area in biological research. The main obstacle in this area is the absence of the full-length crystal structure for HIV-1 integrase to be used as a model. A complete structure, ...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.29773
更新日期:2016-02-15 00:00:00
abstract:BACKGROUND:Human cutaneous infection caused by a homogeneous group of keratinophilic fungi called dermatophytes. These fungi are the most common infectious agents in humans that are free of any population and geographic area. Microsporum canis is a cause of dermatophytosis (Tinea) in recent years in Iran and atypical s...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.8(5)2015.14874
更新日期:2015-05-31 00:00:00
abstract:BACKGROUND:Despite the effectiveness of prophylactic antimicrobials to prevent surgical site infection the use of antibiotic prophylaxis is often inappropriate. OBJECTIVES:The current study aimed to determine the pattern of prophylactic antibiotic use in a teaching hospital affiliated to Jundishapur University of Medi...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.12251
更新日期:2014-11-01 00:00:00
abstract:CONTEXT:Acne vulgaris affects about 85% of teenagers and may continue to adulthood. There are about two million visits to physicians per year for teenagers and the direct cost of acne treatment in the US exceeds $1 billion per year. EVIDENCE ACQUISITION:A wide variety of treatment regimens exist for acne vulgaris incl...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章,评审
doi:10.5812/jjm.25580
更新日期:2015-11-21 00:00:00
abstract:BACKGROUND:Food-borne pathogens are among the most significant problems in maintaining the health of people. Many probiotics have been widely reported to alleviate and protect against gastrointestinal infections through antibacterial secretion. However, the majority of them cannot always play antagonistic roles under g...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.8(5)2015.18264
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Helicobacter pylori is curved Gram negative and microaerophilic bacilli that have infected half of the world's population. It is recognized as the causative agent of duodenal ulcer, gastritis peptic ulcer, mucosa-associated lymphoid tissue (MALT) lymphoma and is associated with gastric adenocarcinoma. Resist...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.29694
更新日期:2016-02-15 00:00:00
abstract:BACKGROUND:Pseudomonas aeruginosais a frequent nosocomial pathogen that causes severe diseases in many settings. Carbapenems, including meropenem and imipenem, are effective antibiotics against this organism. However, the use of carbapenems has been hampered by the emergence of strains resistant to carbapenemsvia diffe...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.22582
更新日期:2015-09-22 00:00:00
abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a major cause of nosocomial infections. Methicillin resistance in S. aureus is caused by the acquisition of the mecA gene, located on a mobile genetic element called the staphylococcal cassette chromosome (SCC). OBJECTIVES:The aim of this st...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.16998v2
更新日期:2015-06-27 00:00:00
abstract:BACKGROUND:Escherichia coli and Klebsiella pneumoniae are common human pathogens that cause a wide spectrum of infections. Antimicrobial resistance is a basic obstacle in the management of these infections which has different patterns in various regions. OBJECTIVES:In this study, the antibiotic resistance patterns and...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.27517
更新日期:2015-10-25 00:00:00
abstract:BACKGROUND:Chlamydia trachomatis is one of the major bacterial agents of the sexually transmitted diseases worldwide, especially among young females. There is no data regarding the prevalence of genital Chlamydia infection among young females in Kashan, Iran. OBJECTIVES:The current study aimed to determine the prevale...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.8(4)2015.15576
更新日期:2015-04-18 00:00:00
abstract:BACKGROUND:Coagulase-negative staphylococci (CoNS), especially Staphylococcus epidermidis, are considered as normal flora of human epithelia and also important opportunistic pathogens for nosocomial infections. S. epidermidis can also act as a reservoir for mecA, responsible for high-level resistance to methicillin and...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.11188
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:The etiology of morphea is still unknown. Borrelia spp. as a causative agent of morphea has been discussed since 1985, but the relationship remains uncertain. OBJECTIVES:We aimed to find the frequency of Borrelia in morphea lesions by polymerase chain reaction (PCR) in northeast of Iran. PATIENTS AND METHO...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.19730v2
更新日期:2015-08-27 00:00:00
abstract:BACKGROUND:Uropathogenic Escherichia coli (UPEC) with its virulence factors is the most prevalent cause of urinary tract infection (UTI). OBJECTIVES:This study aimed to determine the occurrence of fim, pap, sfa, and afa genes among 100 UPEC isolates collected from patients diagnosed with UTI. MATERIALS AND METHODS:A ...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.22647
更新日期:2015-08-17 00:00:00
abstract:BACKGROUND:Infection with non-typhoid Salmonella (NTS) is one of the most important health problems all over the world. Antimicrobial drug resistance is increasing among Salmonella infantis species. OBJECTIVES:The aim of this study was to investigate the frequency of presence of class 1 integrons in S. infantis specie...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.10019
更新日期:2014-05-01 00:00:00
abstract:INTRODUCTION:Acute Hepatitis A Virus (HAV) infection is common in the developing countries among children, but hydrops of gallbladder due to hepatitis A infection is an uncommon presentation. CASE PRESENTATION:A five-year-old boy was admitted in Namazi Hospital, Shiraz, Iran due to jaundice and severe abdominal pain f...
journal_title:Jundishapur journal of microbiology
pub_type:
doi:10.5812/jjm.15779
更新日期:2014-12-10 00:00:00
abstract:BACKGROUND:Mycobacterium tuberculosis is a vicious microbe co-existing with the infected host. This pathogen exploited opportunities to spread during periods of urbanization and social upheaval, and got retreated with improved hygiene. OBJECTIVES:This investigation was designed to clone and characterize M. tuberculosi...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.9367
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:The sensing mechanism of glucose in Saccharomyces cerevisiae is well studied. However, such information is scarcely found in other yeast species such as Candida glabrata. OBJECTIVES:This study aimed to identify the glucose sensing pathway related genes of C. glabrata and to analyze the regulation pattern of...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.25177
更新日期:2015-11-21 00:00:00
abstract:BACKGROUND:Sepsis remains a major problem for both scientists and clinicians. Cecal ligation and puncture (CLP) is considered the gold standard for animal models of sepsis. The undesirable side effects of certain antibiotics have forced scientists to discover new, natural, and safe antimicrobial agents, such as cephalo...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.29331
更新日期:2016-01-02 00:00:00
abstract:BACKGROUND:Enterically-transmitted acute viral hepatitis is caused predominantly by hepatitis A virus (HAV) and hepatitis E virus (HEV). The prevalence of HEV and HAV infections varies in different geographical regions. OBJECTIVES:This study was conducted to determine the prevalence of HEV and HAV infections among Ira...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.19311v2
更新日期:2015-07-27 00:00:00
abstract:BACKGROUND:Acinetobacter baumannii has emerged as a highly troublesome pathogen and a leading cause of mortality and morbidity among hospitalized burn patients. OBJECTIVES:The aims of this study were to determine the frequency of the AdeABC genes and the role of the efflux pump (s) in the imipenem resistance of A. bau...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.19048
更新日期:2015-10-12 00:00:00
abstract:BACKGROUND:Cervical cancer is the leading cause of death from cancer in under-developed countries. Human papilloma virus (HPV) 16 and 18 are the most prevalent types associated with carcinogenesis in the cervix. Conventional Polymerase Chain Reaction (PCR), type-specific and consensus primer-based PCR followed by seque...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.26441
更新日期:2015-12-26 00:00:00
abstract:BACKGROUND:Toxoplasmosis is a public health problem worldwide. This complication principally affects immunodeficient patients and pregnant women. Toxoplasma gondii is an opportunistic parasite, causing severe illness among and death of high-risk individuals and treatment is becoming increasingly difficult owing to side...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.22572
更新日期:2015-09-07 00:00:00
abstract:BACKGROUND:The search for novel antibiotics continues to be of immense importance in research programs around the world for pharmaceutical, industrial and agricultural applications. Filamentous soil bacteria, belonging to the Streptomyces genus, are widely used as an important biological tool for their ability to produ...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.15107
更新日期:2015-02-10 00:00:00
abstract:BACKGROUND:Khuzestan and other parts of Iran were involved with Influenza A (H1N1) pandemic in 2009. OBJECTIVES:The aim of this study was to describe the prevalence and mortality of H1N1 in Behbahan, a city in Khuzestan, Southwest of Iran. PATIENTS AND METHODS:The study population consisted of cases of influenza, hos...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.9263
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The surveillance of kidney transplant patients depends on function of different immunologic markers like co-stimulatory molecules. These molecules may also be associated with post kidney transplant viral related outcomes. OBJECTIVES:The aim of this study was to investigate the possible associations between ...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.31338
更新日期:2016-02-17 00:00:00
abstract:BACKGROUND:Pathogenic mycobacteria are a major cause of human morbidity and mortality. Mycobacterium tuberculosis is an etiological agent of human tuberculosis (TB). Designing new vaccines, including DNA vaccines, may be a useful strategy for preventing TB. OBJECTIVES:The purpose of this study was to design and constr...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.23560
更新日期:2015-10-26 00:00:00
abstract:BACKGROUND:Brucellosis is an inflammatory disease which may infect any organs or systems in the body. Mean Platelet Volume (MPV) is one of the most frequently used surrogate markers of platelet function. It reveals the presence of disease activity in many inflammatory diseases. Red blood cell distribution width (RDW) i...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.20039
更新日期:2015-02-20 00:00:00
abstract:BACKGROUND:At present, limited clinical data is available regarding survival rates of patients co-infected with human immunodeficiency virus (HIV)/tuberculosis (TB) in developing countries. OBJECTIVES:The present study aimed to evaluate the effect of HIV infection on the survival chances of active TB adults who disclo...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.10565
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Enterococci are important pathogens in nosocomial infections. Various types of antibiotics, such as aminoglycosides, are used for treatment of these infections. Enterococci can acquire resistant traits, which can lead to therapeutic problems with aminoglycosides. OBJECTIVES:This study was designed to identi...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.28923
更新日期:2016-03-12 00:00:00