Abstract:
BACKGROUND AND PURPOSE:In advanced Parkinson's disease (PD), the emergence of symptoms refractory to conventional therapy poses a therapeutic challenge. The success of deep brain stimulation (DBS) and advances in the understanding of the pathophysiology of PD have raised interest in non-invasive brain stimulation as an alternative therapeutic tool. The rationale for its use draws from the concept that reversing abnormalities in brain activity and physiology thought to cause the clinical deficits may restore normal functioning. Currently the best evidence in support of this concept comes from DBS, which improves motor deficits, and modulates brain activity and motor cortex physiology, though whether a causal interaction exists remains largely undetermined. CONCLUSION:Most trials of non-invasive brain stimulation in PD have applied repetitive transcranial magnetic stimulation (rTMS) targeting the primary motor cortex and cortical areas of the motor circuit. Published studies suggest a possible therapeutic potential of rTMS and transcranial direct current stimulation (tDCS), but clinical effects so far have been small and negligible regarding functional independence and quality of life. Approaches to potentiate the efficacy of rTMS, including increasing stimulation intensity and novel stimulation parameters, derive their rationale from studies of brain physiology. These novel parameters simulate normal firing patterns or act on the hypothesized role of oscillatory activity in the motor cortex and basal ganglia in motor control. There may also be diagnostic potential of TMS in characterizing individual traits for personalized medicine.
journal_name
NeuroRehabilitationjournal_title
NeuroRehabilitationauthors
Benninger DH,Hallett Mdoi
10.3233/NRE-151237subject
Has Abstractpub_date
2015-01-01 00:00:00pages
11-24issue
1eissn
1053-8135issn
1878-6448pii
NRE1237journal_volume
37pub_type
杂志文章,评审abstract::The purpose of this study was to examine and compare the cognitive profiles of three groups of Israeli individuals who exhibit cognitive deficits for diverse reasons, using the Neurobehavioural Cognitive Status Examination (Cognistat, former name NCSE). The test is a standardized cognitive screening instrument which i...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-1997-9302
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To determine if the demographic characteristics and health care needs of younger people with MS differ from older people with MS. PARTICIPANTS:The study analyzed enrollment data from the NARCOMS Registry to compare 1,987 younger adults with MS (30 years and younger) to 29,245 other adults with MS (over 30 ye...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-2009-0525
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The restoration of trunk function following stroke is a key component of rehabilitation, however there is limited evidence of the efficacy of additional trunk training. OBJECTIVES:To evaluate the efficacy of trunk exercises added to conventional rehabilitation on functional outcomes. METHODS:Relevant rando...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,meta分析,评审
doi:10.3233/NRE-141123
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To generate normative data for the Verbal Fluency Tests across 11 countries in Latin America, with country-specific adjustments for gender, age, and education, where appropriate. METHOD:The sample consisted of 3,977 healthy adults who were recruited from Argentina, Bolivia, Chile, Cuba, El Salvador, Guatemal...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-151279
更新日期:2015-01-01 00:00:00
abstract::The purpose of this paper was to examine the reliability and validity (concurrent and construct) of a newly developed online Chinese version of the Rivermead Behavioral Memory Test (OL-RBMT) and its equivalence with the face-to-face version (FTF-RBMT). The OL-RBMT and FTF-RBMT were administered to 30 subjects with str...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.3233/NRE-2009-0473
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Sleep disturbances are common following traumatic brain injury (TBI). The Pittsburgh Sleep Quality Index (PSQI) is a widely used measure of sleep quality that has been used in numerous populations. Although this measure has been used in TBI research, there are few studies examining the psychometric propertie...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.3233/NRE-141141
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The aim of his study was to evaluate the reliability and validity of the Expanded Timed Get-up-and-Go (ETGUG) test in patients with bilateral vestibular loss (BVL). METHODS:21 BVL patients (58 ± 14 years) were recruited and measured twice by two raters. After a one hour break ETGUG was repeated by the first...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-141083
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Bone loss is a common and often debilitating condition that accompanies spinal cord injury. Because bone loss after spinal cord injury is multifactorial, it can be difficult to assess and treat. This process becomes even more complex as secondary conditions associated with aging are introduced. PURPOSE:Th...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:10.3233/NRE-2011-0702
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The caregivers of Multiple Sclerosis (MS) individuals are usually burdened with a wide range of MS-related caregiving tasks which may result in damages of their daily life and quality of life (QOL). OBJECTIVES:This study was designed to compare according to the disability level (1) the walking ability, qual...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-131037
更新日期:2014-01-01 00:00:00
abstract::A step-by-step case report describes the rehabilitation program for visual dysfunction of a 52-year-old woman, beginning 2 years post-trauma. Methods to ameliorate such symptoms as diplopia, ocular discomfort, dry eye, inefficient saccadic movement, spasms of accommodation, poor reading comprehension and very limited ...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-1996-6304
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of motor swallowing exercises on swallowing dynamic, quality of life and swallowing complaints in Parkinson's disease (PD). DESIGN:A before-after trial. SETTING:University Medical Center. PARTICIPANTS:Parkinson's disease patients with dysphagia complaints. INTERVENTIONS:Motor swa...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-130918
更新日期:2013-01-01 00:00:00
abstract::Research suggests that the occurrence of a traumatic brain injury (TBI) in childhood may disrupt self-regulation abilities, putting children at risk for difficulty on everyday tasks requiring self-regulation throughout their development. In the current exploratory study, a novel age-appropriate task assessed the abili...
journal_title:NeuroRehabilitation
pub_type: 临床试验,杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::This article provides readers with a review of the major considerations for designing living environments for persons with neurodisability due to acquired brain injury (ABI). Components that need to be considered in order to assure that the environment is designed with a functional perspective in mind are explored. Th...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:10.3233/NRE-2009-0518
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Trunk alignment is thought to contribute to neck function. However, this common assumption is not clear in patients with Parkinson's disease (PwPD) suffering from different postural deformities such as: Pisa syndrome (PS), Camptocormia & Antecollis (C&A). OBJECTIVES:to investigate the effect of different po...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-182505
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Brain-computer interfaces (BCIs) allow persons with impaired mobility to communicate and interact with the environment, supporting goal-directed thinking and cognitive function. Ideally, a BCI should be able to recognize a user's internal state and adapt to it in real-time, to improve interaction. OBJECTIVE...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,meta分析,评审
doi:10.3233/NRE-151266
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Robot-assisted gait training provide a big therapeutic advantage in functional mobility for postural control. OBJECTIVES:The purpose of this study was investigate the effects of robot-assisted gait training using virtual reality and auditory stimulation on balance and gait abilities in stroke patients. MET...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.3233/NRE-172415
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Endocrinopathy, including hypogonadism, is common following traumatic brain injury (TBI). Prior evidence suggests hypogonadism is associated with poorer function. OBJECTIVE:Determine the feasibility, safety, and efficacy of testosterone (T) therapy in hypogonadal men following TBI in acute rehabilitation. ...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.3233/NRE-192992
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Individuals with Amyotrophic Lateral Sclerosis (ALS) exhibit speech disorders since the early stages that decrease the communication rate and interfere in social participation. OBJECTIVE:To conduct a literature review on communication vulnerable and Augmentative and Alternative Communication (AAC) in Amyotr...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:10.3233/NRE-171443
更新日期:2017-01-01 00:00:00
abstract::The purpose of this study was to examine the relationship between exaggeration and scores on a test of olfactory discrimination in patients being assessed in connection with a claim for financial benefits. Participants were 448 patients referred to a private practice in Edmonton, Alberta, Canada for psychological or n...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:White matter lesions (WML) are prevalent in older adults. The association between WML and cognition in different subtypes of Mild Cognitive Impairment (MCI) is inconsistent in the literature. OBJECTVES:We aim to provide a systematic review on the impact of WML in different subtypes of MCI, and discuss the r...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:10.3233/NRE-171471
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The Timed up and go test (TUG), the Five times sit-to-stand test (FTSTS) and the Bed Mobility test (BMT) are widely used in clinical practice for Parkinson Disease (PD). However, no reported studies have evaluated the responsiveness to group physical therapy intervention (GPTI). OBJECTIVE:To verify if TUG, ...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-172379
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:This investigation examined the demographic characteristics along with 3 measures of motor function in determining outcomes in activities of daily living (ADL) after distributed constraint-induced therapy (dCIT). METHODS:The study recruited 69 stroke patients who received 3 weeks of dCIT for 2 hours daily, 5...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-2012-0755
更新日期:2012-01-01 00:00:00
abstract::Removal of an indwelling catheter and the initiation of intermittent catheterization (IC) has become a standard urological goal over the past decades. While realistic for men it is more difficult for women, mainly due to their anatomical differences and lack of development of a satisfactory external collection device....
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-1994-4407
更新日期:1994-01-01 00:00:00
abstract::Little is known about prognostic factors associated with motor outcome when the corticospinal tract (CST) was compressed by hematoma. Using diffusion tensor tractography (DTT), we attempted to investigate prognostic factors for motor outcome in patients whose affected CST was compressed by hematoma. The study included...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-2011-0681
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Contemporary goals of rehabilitation after traumatic brain injury (TBI) aim to improve cognitive and motor function by applying concepts of neuroplasticity. This can be challenging to carry out in TBI patients with motor, balance, and cognitive impairments. OBJECTIVE:To determine whether use of dynamic body...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-192898
更新日期:2019-12-18 00:00:00
abstract:BACKGROUND:Assessment of impaired motor behaviour serves as tool for diagnosis and for evaluation of progression of chronic neurodegeneration. METHODS:We measured performance of rapid alternating movements, simple and complex motion series with instruments in scored, drug naïve patients with Huntington's disease and c...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-130992
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To determine the effect of repeated passive motion (RPM) exercise on position sense of the shoulder joint in patients with hemiplegia. METHODS:Shoulder flexion position sense was evaluated for the affected side of 15 patients with hemiplegia, using an assessment board set at five angles (30 degrees, 60 degre...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-2009-0504
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The Functional Assessment for Control of Trunk (FACT) was developed to evaluate trunk function after stroke. However, only a few studies used FACT to show functional outcome. OBJECTIVE:This study aimed to validate the FACT predictive ability for functional outcome following stroke and create an English vers...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-201533
更新日期:2021-01-01 00:00:00
abstract::The corticospinal tract (CST) is the most important neural tract for motor function in the human brain. Therefore, clarification of CST injury would be an important topic in traumatic brain injury (TBI) rehabilitation. In this review, I reviewed diffusion tensor imaging (DTI) studies on CST injuries in terms of etiolo...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:10.3233/NRE-2011-0710
更新日期:2011-01-01 00:00:00
abstract::This review provides an overview of pediatric ischemic stroke to serve as a foundation for the discussion of rehabilitation strategies following focal injury in the developing brain. Cerebrovascular disease is an important cause of acquired brain injury in neonates and children. Ischemic strokes are caused by a multit...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00