NIR-driven Smart Theranostic Nanomedicine for On-demand Drug Release and Synergistic Antitumour Therapy.

abstract：:Pyrosomes are tunicates in the phylum Chordata, which also contains vertebrates. Their gigantic blooms play important ecological and biogeochemical roles in oceans. Pyrosoma, meaning "fire-body", derives from their brilliant bioluminescence. The biochemistry of this light production is unknown, but has been hypothesiz...

journal_title：Scientific reports

authors： Tessler M,Gaffney JP,Oliveira AG,Guarnaccia A,Dobi KC,Gujarati NA,Galbraith M,Mirza JD,Sparks JS,Pieribone VA,Wood RJ,Gruber DF

更新日期：2020-10-20 00:00:00

abstract：:Tunneling nanotubes (TNTs) are actin-based membranous structures bridging distant cells for intercellular communication. We define roles for TNTs in stress adaptation and treatment resistance in prostate cancer (PCa). Androgen receptor (AR) blockade and metabolic stress induce TNTs, but not in normal prostatic epithel...

journal_title：Scientific reports

authors： Kretschmer A,Zhang F,Somasekharan SP,Tse C,Leachman L,Gleave A,Li B,Asmaro I,Huang T,Kotula L,Sorensen PH,Gleave ME

更新日期：2019-05-24 00:00:00

abstract：:In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have onl...

journal_title：Scientific reports

authors： Loley C,Alver M,Assimes TL,Bjonnes A,Goel A,Gustafsson S,Hernesniemi J,Hopewell JC,Kanoni S,Kleber ME,Lau KW,Lu Y,Lyytikäinen LP,Nelson CP,Nikpay M,Qu L,Salfati E,Scholz M,Tukiainen T,Willenborg C,Won HH,Zeng L

更新日期：2016-10-12 00:00:00

abstract：:Cardiotrophin-1 is known to be a key regulator of energy homeostasis, as well as glucose and lipid metabolism in vivo. However, there are inconsistent results of the association between cardiotrophin-1 and obesity in humans, possibly confounded by hyperglycemia. Therefore, the aim of this study was to investigate the ...

journal_title：Scientific reports

authors： Hung HC,Lu FH,Wu HT,Ou HY,Yang YC,Wu JS,Chang CJ

更新日期：2015-12-01 00:00:00

abstract：:A marine isolate, Nesiotobacter exalbescens COD22, isolated from deep sea sediment (2100 m depth) was capable of degrading aromatic hydrocarbons. The Nesiotobacter sp. grew well in the presence of toluene at 0.1 MPa and 10 MPa at a rate of 0.24 h-1 and 0.12 h-1, respectively, in custom designed high pressure reactors....

journal_title：Scientific reports

authors： Ganesh Kumar A,Mathew NC,Sujitha K,Kirubagaran R,Dharani G

更新日期：2019-12-10 00:00:00

abstract：:Screening programs for lung cancer aim to allow diagnosis at the early stage, and therefore the decline in mortality rates. Thus, the aim of this retrospective cohort study was to the comparison of screened and non-screened lung cancer in terms of lung cancer characteristics, overdiagnosis and survival rate. A retrosp...

journal_title：Scientific reports

authors： Wu FZ,Kuo PL,Huang YL,Tang EK,Chen CS,Wu MT,Lin YP

更新日期：2019-12-18 00:00:00

abstract：:The current study aims at characterizing the mechanisms that allow humans to entrain the mind and body to incoming rhythmic sensory inputs in real time. We addressed this unresolved issue by examining the relationship between covert neural processes and overt behavior in the context of musical rhythm. We measured temp...

journal_title：Scientific reports

authors： Nozaradan S,Peretz I,Keller PE

更新日期：2016-02-05 00:00:00

abstract：:Site variation in fixation, staining, and scanning can confound automated tissue based image classifiers for disease characterization. In this study we incorporated stability into four feature selection methods for identifying the most robust and discriminating features for two prostate histopathology classification t...

journal_title：Scientific reports

authors： Leo P,Elliott R,Shih NNC,Gupta S,Feldman M,Madabhushi A

更新日期：2018-10-08 00:00:00

abstract：:It is notable that the adoption of GM glyphosate-tolerant crops increases glyphosate use but reduces non-glyphosate herbicide use; and adoption of GM insect-resistant crops significantly reduces insecticide use. While the health hazard of pesticide use has been well documented, little literature evaluates the health e...

journal_title：Scientific reports

authors： Zhang C,Hu R,Huang J,Huang X,Shi G,Li Y,Yin Y,Chen Z

更新日期：2016-10-10 00:00:00

abstract：:Galectin-3 is a biomarker of fibrosis, inflammation and oxidative stress, and its role in heart remodelling and exercise intolerance has not been conclusively proven in heart failure (HF) patients with reduced ejection fraction (rEF). We prospectively assessed 67 consecutive patients with symptomatic HF and left ventr...

journal_title：Scientific reports

authors： Zaborska B,Sygitowicz G,Smarż K,Pilichowska-Paszkiet E,Budaj A

更新日期：2020-10-07 00:00:00

abstract：:Thus far, underwater and underground positioning techniques have been limited to those using classical waves (sound waves, electromagnetic waves or their combination). However, the positioning accuracy is strongly affected by the conditions of media they propagate (temperature, salinity, density, elastic constants, op...

journal_title：Scientific reports

authors： Tanaka HKM

更新日期：2020-11-03 00:00:00

abstract：:The newly designed fentanyl derivative [( ±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide] (NFEPP) was recently shown to produce analgesia selectively via peripheral mu-opioid receptors (MOR) at acidic pH in rat inflamed tissues. Here, we examined the pH-dependency of NFEPP binding to brain MOR and it...

journal_title：Scientific reports

authors： Baamonde A,Menéndez L,González-Rodríguez S,Lastra A,Seitz V,Stein C,Machelska H

更新日期：2020-10-29 00:00:00

abstract：:Nucleotide excision repair (NER) excises bulky DNA lesions induced by mutagens and carcinogens. The repair process includes recognition of DNA damage, excision of a short patch of nucleotides containing the damaged base, re-synthesis of a new DNA strand and ligation of the nicks to restore the sequence integrity. Muta...

journal_title：Scientific reports

authors： Shen JC,Fox EJ,Ahn EH,Loeb LA

更新日期：2014-05-08 00:00:00

abstract：:Al substitution in hematite is ubiquitous in soils. With the increase of Al amount, the hematite morphology changes from rhombohedral crystals to disk-shaped ones, but the underlying mechanism is poorly understood. Herein, a series of Al-substituted hematite were synthesized and characterized by synchrotron X-ray diff...

journal_title：Scientific reports

authors： Li W,Liang X,An P,Feng X,Tan W,Qiu G,Yin H,Liu F

更新日期：2016-10-27 00:00:00

abstract：:Osteosarcoma pulmonary metastases are typically treated with resection and/or chemotherapy. We hypothesize that stereotactic radiosurgery (SRS) can be an alternative to surgery that can achieve high rates of local control with limited toxicity. From January 2005 to December 2013, 73 patients who developed pulmonary me...

journal_title：Scientific reports

authors： Yu W,Liu Z,Tang L,Lin F,Yao Y,Shen Z

更新日期：2017-12-12 00:00:00

abstract：:Practical application of superhydrophobic surfaces is limited by the fragility of nanoscale asperities. Combining chemical etching and anodization, microscale pits and nanoscale pores, instead of the micro and nano protrusions on traditional superhydrophobic surfaces mimicking Lutos leaves, were fabricated on commerci...

journal_title：Scientific reports

authors： Wang G,Liu S,Wei S,Liu Y,Lian J,Jiang Q

更新日期：2016-02-08 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen that thrives in diverse environments and causes a variety of human infections. Pseudomonas aeruginosa AG1 (PaeAG1) is a high-risk sequence type 111 (ST-111) strain isolated from a Costa Rican hospital in 2010. PaeAG1 has both blaVIM-2 and blaIMP-18 genes encoding for...

journal_title：Scientific reports

authors： Molina-Mora JA,Chinchilla-Montero D,Chavarría-Azofeifa M,Ulloa-Morales AJ,Campos-Sánchez R,Mora-Rodríguez R,Shi L,García F

更新日期：2020-08-13 00:00:00

abstract：:The tick receptor for outer surface protein A (TROSPA) is the only identified factor involved in tick gut colonization by various Borrelia species. TROSPA is localized in the gut epithelium and can recognize and bind the outer surface bacterial protein OspA via an unknown mechanism. Based on earlier reports and our la...

journal_title：Scientific reports

authors： Urbanowicz A,Lewandowski D,Szpotkowski K,Figlerowicz M

更新日期：2016-04-26 00:00:00

abstract：:Retinal diseases generally are vision-threatening conditions that warrant appropriate clinical decision-making which currently solely dependents upon extensive clinical screening by specialized ophthalmologists. In the era where molecular assessment has improved dramatically, we aimed at the identification of biomarke...

journal_title：Scientific reports

authors： Kuiper JJ,Beretta L,Nierkens S,van Leeuwen R,Ten Dam-van Loon NH,Ossewaarde-van Norel J,Bartels MC,de Groot-Mijnes JD,Schellekens P,de Boer JH,Radstake TR

更新日期：2017-01-27 00:00:00

abstract：:Multigene expression signatures provide a molecular subdivision of early breast cancer associated with patient outcome. A gap remains in the validation of such signatures in clinical treatment groups of patients within population-based cohorts of unselected primary breast cancer representing contemporary disease stage...

journal_title：Scientific reports

authors： Vallon-Christersson J,Häkkinen J,Hegardt C,Saal LH,Larsson C,Ehinger A,Lindman H,Olofsson H,Sjöblom T,Wärnberg F,Ryden L,Loman N,Malmberg M,Borg Å,Staaf J

更新日期：2019-08-21 00:00:00

abstract：:Silica columns from PCR purification and gel extraction kits are widely used in laboratories worldwide to assist in gene cloning. However, the use of these columns can generate plastic waste that has an environmental impact due to their one-off design and massive consumption. Thus, it is important to develop a novel m...

journal_title：Scientific reports

authors： Zhou Y,Zhang Y,He W,Wang J,Peng F,Huang L,Zhao S,Deng W

更新日期：2018-08-27 00:00:00

abstract：:Monosodium Glutamate (MSG) is used as flavour enhancer, with potential beneficial effects due to its nutritional value. Given the decline in kidney functions during aging, we investigated the impact of MSG voluntary intake on the kidney of male mice, aged 6 or 18 months. For 2 months, they freely consumed water (contr...

journal_title：Scientific reports

authors： Celestino M,Balmaceda Valdez V,Brun P,Castagliuolo I,Mucignat-Caretta C

更新日期：2021-01-12 00:00:00

abstract：:Conventional disease animal models have limitations on the conformity to the actual clinical situation. Disease-syndrome combination (DS) modeling may provide a more efficient strategy for biomedicine research. Disease model and DS model of renal fibrosis in chronic kidney disease were established by ligating the left...

journal_title：Scientific reports

authors： Li S,Xu P,Han L,Mao W,Wang Y,Luo G,Yang N

更新日期：2017-08-18 00:00:00

abstract：:We report here that CYB5D2 is associated with tumor suppression function in breast cancer (BC). CYB5D2 expression was significantly reduced in tamoxifen resistant MCF7 cells and in MCF7 cell-derived xenografts treated with TAM. CYB5D2 overexpression induced apoptosis in MCF7 cells; CYB5D2 knockdown enhanced MCF7 cell ...

journal_title：Scientific reports

authors： Ojo D,Rodriguez D,Wei F,Bane A,Tang D

更新日期：2019-04-29 00:00:00

abstract：:c-FLIP (cellular FLICE-inhibitory protein) is the pivotal regulator of TRAIL resistance in cancer cells, It is a short-lived protein degraded through the ubiquitin/proteasome pathway. The discovery of factors and mechanisms regulating its protein stability is important for the comprehension of TRAIL resistance by tumo...

journal_title：Scientific reports

authors： Gao X,Feng J,He Y,Xu F,Fan X,Huang W,Xiong H,Liu Q,Liu W,Liu X,Sun X,He QY,Zhang Q,Liu L

更新日期：2016-03-14 00:00:00

abstract：:MicroRNAs (miRNAs) are important effectors in mediating host-pathogen interaction. In this report, coelomocytes miRNA libraries of three Japanese sea cucumbers Apostichopus japonicus were built by Illumina(®) Hiseq2000 from different time points after lipopolysaccharide challenge (at time 0 h, 6 h and 12 h). The clean...

journal_title：Scientific reports

authors： Zhong L,Zhang F,Zhai Y,Cao Y,Zhang S,Chang Y

更新日期：2015-12-04 00:00:00

abstract：:Feedback information is essential for us to adapt appropriately to the environment. The feedback-related negativity (FRN), a frontocentral negative deflection after the delivery of feedback, has been found to be larger for outcomes that are worse than expected, and it reflects a reward prediction error derived from th...

journal_title：Scientific reports

authors： Gu Y,Hu X,Pan W,Yang C,Wang L,Li Y,Chen A

更新日期：2016-10-03 00:00:00

abstract：:Potato (Solanum tuberosum L.) is the fourth most important crop worldwide. Potato virus A (PVA) is one of the most harmful viruses infecting potatoes. However, the molecular mechanisms governing the responses to PVA infection in potato at the transcriptional and post-transcriptional levels are not well understood. In ...

journal_title：Scientific reports

authors： Li Y,Hu X,Chen J,Wang W,Xiong X,He C

更新日期：2017-12-05 00:00:00

abstract：:Faces presented upside-down are harder to recognize than presented right-side up, an effect known as the face inversion effect. With inversion the perceptual processing of the spatial relationship among facial parts is disrupted. Previous literature indicates a face inversion effect in chimpanzees toward familiar and ...

journal_title：Scientific reports

authors： Dahl CD,Rasch MJ,Tomonaga M,Adachi I

更新日期：2013-01-01 00:00:00

abstract：:Archeological researches have proposed arguments for human mobility and long-distance trading over the Eurasia before the Silk Roads. Here we utilize biologically available strontium isotope analysis to assess the extent of pre-Silk Road population movements and cultural communications across the Asian interior. From ...

journal_title：Scientific reports

authors： Wang X,Tang Z,Wu J,Wu X,Wu Y,Zhou X

更新日期：2016-10-20 00:00:00