当前位置： SCI文献检索 > MICROBIOLOGY AND IMMUNOLOGY期刊下所有文献 > Early-shared Mycobacterium bovis bacillus Calmette-Guérin sub-strains induce Th1 cytokine production in vivo.

Early-shared Mycobacterium bovis bacillus Calmette-Guérin sub-strains induce Th1 cytokine production in vivo.

Abstract：

:Interleukin-12 is one of the cytokines that induce acquired immunity by progressing the differentiation of T cells. When antigens are presented by APCs, including macrophages and DCs, T cells are activated and produce the Th1 cytokines IL-2 and IFN-γ. We have previously reported greater IL-12 production from macrophages infected with early-shared BCG sub-strains (ex. BCG-Japan, -Sweden) than from those infected with late-shared BCG (ex. BCG-Pasteur and -Connaught) . In this study, we investigated the Th1 cytokine-inducing activity of splenocytes co-cultured with BCG-infected DCs. Early-shared BCG-infected DCs produced IL-12 and TNF-α⋅ Furthermore, when they were co-cultured with purified protein derivative-stimulated DCs, the splenocytes of mice immunized with BCG-Tokyo/Japan produced more Th1 cytokine than did those of mice immunized with BCG-Connaught. In conclusion, early-shared BCG sub-strains more strongly induce Th1 cytokine production in vivo. This study provides basic information to inform the selection of candidates for primary vaccination.

journal_name

Microbiol Immunol

journal_title

Microbiology and immunology

authors

Taniguchi K,Miyatake Y,Hayashi D,Takami A,Itoh S,Yamamoto S,Hida S,Onozaki K,Takii T

doi

10.1111/1348-0421.12326

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

684-9

issue

11

eissn

0385-5600

issn

1348-0421

journal_volume

59

pub_type

杂志文章

相关文献

MICROBIOLOGY AND IMMUNOLOGY文献大全
  • Human immunodeficiency virus type 1 neutralization by a single molecule of V3-targeted antibody.

    abstract：:Human immunodeficiency virus type-1 (HIV-1) infection generally provokes antibody responses to the viral envelope glycoprotein. Two major regions of gp120, the third variable (V3) domain and the CD4-binding site, have been identified as neutralization targets. The precise mechanism of HIV-1 neutralization by antibodie...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.2002.tb02773.x

    authors： Harada S

    更新日期：2002-01-01 00:00:00

  • Nucleotide sequence of the 5'nontranslated and virion polypeptides regions of coxsackievirus B6.

    abstract：:The nucleotide sequence of coxsackievirus B6 (CVB6) has been determined, and the nucleotides encoding the 5' nontranslated region (5' NTR) and virion polypeptides (VP4, 2, 3 and 1) were compared with other serotype CVBs. An Unweighted Pair-Group Method Analysis (UPGMA) of phylogenetic trees indicated that the 5' NTR o...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1999.tb01222.x

    authors： Kato S,Tsutsumi R,Sato S

    更新日期：1999-01-01 00:00:00

  • Filamentous phage fs1 of Vibrio cholerae O139.

    abstract：:Filamentous phage, fs1, was obtained from Vibrio cholerae O139. The lysogenized strains produced a large amount of fs1 phage in the culture supernatant. This phage was previously reported as novel fimbriae of that organism. The genome of the phage was a 6.5 kb single-stranded DNA. The capsid of fsl consists of a small...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1998.tb02277.x

    authors： Nakasone N,Honma Y,Toma C,Yamashiro T,Iwanaga M

    更新日期：1998-01-01 00:00:00

  • Genus Enhydrobacter Staley et al. 1987 should be recognized as a member of the family Rhodospirillaceae within the class Alphaproteobacteria.

    abstract：:The genus Enhydrobacter, first reported as a member of the family Vibrionaceae, has been placed in the family Moraxellaceae, but as a genus incertae sedis in Bergey's Manual of Systematic Bacteriology 2nd edition. During our taxonomic investigation of Enhydrobacter-like organisms, we observed that the 16S rRNA sequenc...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.2011.00401.x

    authors： Kawamura Y,Fujiwara N,Naka T,Mitani A,Kubota H,Tomida J,Morita Y,Hitomi J

    更新日期：2012-01-01 00:00:00

  • Mycoplasma pulmonis arthritis in congenitally athymic (nude) mice. Clinical and biological features.

    abstract：:Congenitally athymic BALB/cA nu/nu mice were employed to elucidate the role of the thymus in experimental Mycoplasma pulmonis strain m53 infection, and nu/+ mice were used for comparison. Chronic polyarthritis was frequently produced in both of nu/nu and nu/+ mice by intravenous injection of the organisms. Macroscopic...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1979.tb00537.x

    authors： Tanaka H

    更新日期：1979-01-01 00:00:00

  • Clostridium botulinum type C in healthy swine in Japan.

    abstract：:Healthy cattle and swine bred in a district of Japan were examined for the presence of Clostridium botulinum in their liver. Liver specimens were cultivated in chopped meat-glucose medium and the cultures were examined for botulinum toxin. In cattle, none of the cultures of 100 liver specimens yielded the toxin. In sw...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1992.tb01639.x

    authors： Yamakawa K,Kamiya S,Yoshimura K,Nakamura S

    更新日期：1992-01-01 00:00:00

  • Phosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A.

    abstract：:In recent years, phosphatidylinositol 4-kinase III beta (PI4KB) has emerged as a conserved target of anti-picornavirus compounds. In the present study, PI4KB was identified as the direct target of the plant-derived anti-picornavirus compounds, oxoglaucine and pachypodol (also known as Ro 09-0179). PI4KB was also ident...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/1348-0421.12261

    authors： Arita M,Philipov S,Galabov AS

    更新日期：2015-06-01 00:00:00

  • Staphylococcus aureus requires increased level of Ca(2+) or Mn(2+) to grow normally in a high-NaCl/low-Mg(2+) medium.

    abstract：:Mg2+-availability in Staphylococcus aureus cells decreased significantly with increasing NaCl concentration in growth media. Cells grew in a NaCl-free, Chelex resin-treated complex medium only if the medium was supplemented with 50 microM MgCl2, while, growth was limited when the medium was further supplemented with 1...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.2001.tb01313.x

    authors： Ochiai T

    更新日期：2001-01-01 00:00:00

  • Autolysis of Porphyromonas gingivalis is accompanied by an increase in several periodontal pathogenic factors in the supernatant.

    abstract：:Porphyromonas gingivalis autolyzes in the culture media. To examine in more detail the molecular components of the autolysate, two-dimensional gel electrophoresis was performed. Many protein spots varied both in number and volume. One of these spots included Arg-gingipain (Rgp) as determined by N-terminal amino acid s...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.2004.tb03550.x

    authors： Kamaguchi A,Nakano M,Shoji M,Nakamura R,Sagane Y,Okamoto M,Watanabe T,Ohyama T,Ohta M,Nakayama K

    更新日期：2004-01-01 00:00:00

  • Immunopotentiating activity of whole cells and mini-cells of Salmonella typhimurium.

    abstract：:Salmonella typhimurium strain 9 produces mini-cells during cell proliferation. Mini-cells are viable but cannot proliferate since they do not contain chromosomal DNA. Effects of whole cells and mini-cells of S. typhimurium on the immune responses were investigated, with the following results. Phagocytosis of peritonea...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1981.tb00049.x

    authors： Kurashige S,Yoshida T,Kodama K,Mitsuhashi S

    更新日期：1981-01-01 00:00:00

  • A mouse model of the pathogenesis and postexposure prophylaxis of rabies.

    abstract：:A mouse model for the study of postexposure prophylaxis of rabies was established. Mice injected intramuscularly with a street strain of rabies virus were significantly protected from death by five daily 0.2-ml doses of inactivated rabies vaccine of chick embryo cell culture origin initiated immediately or 3 hr after ...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1980.tb02888.x

    authors： Mifune K,Shichijo A,Makino Y,Takeuchi E,Yamada A,Sakamoto K

    更新日期：1980-01-01 00:00:00

  • Macrophage migration inhibitory factor (MIF) produced by a human T cell hybridoma clone.

    abstract：:A human T cell hybridoma clone, F5, producing high levels of macrophage migration inhibitory factor (MIF) was established by the emetine-actinomycin D selection method. This clone produced two species of MIF which were separated on a Phenyl Sepharose column. We purified MIF-2 (the more hydrophobic species of the two) ...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1991.tb01552.x

    authors： Hirose S,Ooki S,Higuchi M,Osawa T

    更新日期：1991-01-01 00:00:00

  • Immunological characterization of lipopolysaccharides from Proteus strains used in Weil-Felix test and reactivity with patient sera of tsutsugamushi diseases.

    abstract：:Immunological analyses of lipopolysaccharides (LPS) isolated from Proteus strains OX2, OX19, and OXK used as antigens of Weil-Felix (WF) test, were performed by quantitative agglutination, enzyme-linked immunosorbent assay (ELISA), and immunoblotting. Antisera against LPS and whole cells (WC) of the three Proteus stra...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1990.tb00998.x

    authors： Amano K,Mizushiri S,Fujii S,Fukushi K,Suto T

    更新日期：1990-01-01 00:00:00

  • Cloning of hok gene into anhydrotetracycline inducible pASK75 vector reveals potent antimicrobial effect of 19 amino acid long N-terminal fragment of hok peptide.

    abstract：:An important toxin-antitoxin (TA) system hok/sok, encoded by R1 plasmid of Escherichia coli, is involved in the post segregation killing of cells that have lost the plasmid. The lethal properties of hok protein have been utilized for the environmental containment of microbes and the development of potential vaccine ca...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/1348-0421.12849

    authors： Kaur A,Muthukumarappa T,Kanta P,Banday AZ,Chidananda MK

    更新日期：2020-11-01 00:00:00

  • Cell elongation and cell death of helicobacter pylori is modulated by the disruption of cdrA (cell division-related gene A).

    abstract：:The cell division-related gene A (cdrA) of Helicobacter pylori is dispensable in vivo and unique in having a repressive role on cell division and long-term survival. To clarify its role, comparisons of the wildtype HPK5 and isogenic cdrA-disrupted mutant HPKT510 were examined by ultrastructural morphology, PBP profile...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.2006.tb03819.x

    authors： Takeuchi H,Nakazawa T,Okamoto T,Shirai M,Kimoto M,Nishioka M,Con SA,Morimoto N,Sugiura T

    更新日期：2006-01-01 00:00:00

  • Suppressive effect of topoisomerase inhibitors on JC polyomavirus propagation in human neuroblastoma cells.

    abstract：:JC polyomavirus (JCPyV) causes progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease of the central nervous system, in immunocompromised patients. Because no drugs have been approved for treating PML, many antiviral agents are currently being investigated for this purpose. The inhibitory effe...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/1348-0421.12372

    authors： Nukuzuma S,Nakamichi K,Kameoka M,Sugiura S,Nukuzuma C,Tasaki T,Takegami T

    更新日期：2016-04-01 00:00:00

  • Effect of activation of the Epstein-Barr virus genome on expression of B cell differentiation antigens of Burkitt's lymphoma lines.

    abstract：:Using anti-human B cell monoclonal antibodies prepared against B1 (CD20), B2 (CD21), B4 (CD19), and BB-1 (B lymphoblast antigen-1), we compared the expression of B cell differentiation antigens on a Jijoye-P3HR-1 cell line family of Burkitt's lymphomas. The expression of BB-1 and B2 antigens was faint on P3HR-1 K cell...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1988.tb01457.x

    authors： Yokochi T,Inoue Y,Iwata H,Miyadai T,Kimura Y

    更新日期：1988-01-01 00:00:00

  • Adhesion of Staphylococcus aureus to bovine mammary epithelial cells induced by growth in milk whey.

    abstract：:Staphylococcus aureus strains isolated from bovine intramammary infection (mastitis) were tested for adhesion to bovine mammary epithelial cells after growth in milk whey or TSB. Bacteria grown in milk whey adhered more efficiently to mammary gland epithelial cells in vitro than the corresponding homologous bacteria g...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1994.tb01781.x

    authors： Mamo W,Fröman G

    更新日期：1994-01-01 00:00:00

  • Immunological studies of a 21 kDa cellular component efficiently incorporated into rabies virion grown in a BHK-21 cell culture.

    abstract：:To investigate cellular components incorporated into the rabies virion, monoclonal antibodies (MAbs) were screened based on their reactivity with additional virion components. Two of the MAbs we prepared recognized a virion-associated 21 kDa polypeptide (referred to as VAP21) from a BHK-21 cell. Since the MAbs precipi...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1997.tb01954.x

    authors： Sagara J,Tochikura TS,Yamamoto T,Tsukita S,Tsukita S,Kawai A

    更新日期：1997-01-01 00:00:00

  • Moraxella (Branhamella) catarrhalis adherence to human bronchial and oropharyngeal cells: the role of adherence in lower respiratory tract infections.

    abstract：:To study the role of Moraxella (subgenus Branhamella) catarrhalis (B. catarrhalis) adherence to airway cells in lower respiratory tract infections, the in vitro attachments of B. catarrhalis to upper airway (oropharyngeal) and lower airway (bronchial) epithelial cells were compared. The adherence of 4 strains (1 nonfi...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1997.tb01882.x

    authors： Rikitomi N,Ahmed K,Nagatake T

    更新日期：1997-01-01 00:00:00

  • Purine metabolic enzymes in lymphocytes. II. Adenosine deaminase and purine nucleoside phosphorylase activities in the immune response.

    abstract：:ICR mice were immunized with sheep red blood cells (sRBC). Both adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) activities in spleen lymphocytes increased faster than the serum antibody titer and reached a peak one week after the immunization. ADA activity increased significantly in T lymphocytes b...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1982.tb00156.x

    authors： Kurashige S,Akuzawa Y,Yoshida T,Teshima C,Kodama K,Mitsuhashi S

    更新日期：1982-01-01 00:00:00

  • Comparative characterization of inducible and virulent Vibrio parahaemolyticus bacteriophages having unique head projections.

    abstract：:Phage TP1, induced from Vibrio parahaemolyticus K-20 pilot strain by mitomycin C, exhibited a unique hexagonal head with knob-like projections which covered the whole capsid and a noncontractile tail. The appearance of this phage was very similar to those of phages VP3 and VP6, isolated from seawater. The host range o...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1991.tb01532.x

    authors： Koga T,Kawata T

    更新日期：1991-01-01 00:00:00

  • Neutrophil extracellular Taps play an important role in clearance of Streptococcus suis in vivo.

    abstract：:Streptococcus suis infection induces formation of neutrophil extracellular traps (NETs) in vitro; however, the contribution of NETs-mediated killing to the pathogenesis of S. suis in vivo is yet to be elicited. The findings of the present study indicated that extracellular DNA fiber can be induced in a murine model in...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/1348-0421.12367

    authors： Zhao J,Lin L,Fu L,Han L,Zhang A

    更新日期：2016-04-01 00:00:00

  • Infection of J774A.1 with different Mycobacterium species induces differential immune and miRNA-related responses.

    abstract：:Macrophages act as a reservoir for Mycobacterium tuberculosis, producing latent infection in approximately 90% of infected people. In this study, J774A.1 mouse macrophage cell line response and microRNA (miRNA) expression during infection with the most relevant mycobacterial strains for humans (M. tuberculosis, M. bov...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/1348-0421.12380

    authors： Elizabeth MC,Hernández de la Cruz ON,Mauricio CA

    更新日期：2016-05-01 00:00:00

  • Regulation of marA, soxS, rob, acrAB and micF in Salmonella enterica serovar Typhimurium.

    abstract：:Importance of the overexpression of AcrAB efflux pumps in the low-level resistance of pathogens to antimicrobials requires a better understanding of the AcrAB regulation. The goal of the present research was to study the transcription of acrAB, as well as the genes that play a role in its regulation in Salmonella ente...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.2008.00075.x

    authors： Hartog E,Ben-Shalom L,Shachar D,Matthews KR,Yaron S

    更新日期：2008-12-01 00:00:00

  • Characterization of an outer membrane protein gene, pgmA, and its gene product from Porphyromonas gingivalis.

    abstract：:A gene upstream from fimA, the gene encoding fimbrilin, on the chromosome of Porphyromonas gingivalis was sequenced and shown to be the gene encoding an outer membrane protein in this organism based on homology and biochemical analyses. Therefore, the gene (formerly ORF5) was designated pgmA, the P. gingivalis outer m...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1999.tb03354.x

    authors： Hongo H,Osano E,Ozeki M,Onoe T,Watanabe K,Honda O,Tani H,Nakamura H,Yoshimura F

    更新日期：1999-01-01 00:00:00

  • Expression of the colH gene encoding Clostridium histolyticum collagenase in Bacillus subtilis and its application to enzyme purification.

    abstract：:The colH gene encoding 116-kDa collagenase of Clostridium histolyticum (cColH) was cloned into an Escherichia coli-Bacillus subtilis shuttle vector to develop a method for purification of recombinant collagenase (rColH). When plasmid pJCM310 containing the colH gene was introduced into B. subtilis DB104 and the transf...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.1996.tb01161.x

    authors： Jung CM,Matsushita O,Katayama S,Minami J,Ohhira I,Okabe A

    更新日期：1996-01-01 00:00:00

  • Mycobacterial cord factor enhances migration of neutrophil-like HL-60 cells by prolonging AKT phosphorylation.

    abstract：:Trehalose 6,6'-dimycolate (TDM), or cord factor, is a crucial stimulus of immune responses during Mycobacterium tuberculosis infection. Although TDM has immuno-stimulatory properties, including adjuvant activity and the ability to induce granuloma formation, the mechanisms underlying these remain unknown. We hypothesi...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/1348-0421.12544

    authors： Lee WB,Yan JJ,Kang JS,Chung S,Kim LK

    更新日期：2017-12-01 00:00:00

  • Functional analysis of the type III secretion system in enteropathogenic Escherichia coli O157:H45.

    abstract：:A mass outbreak of Escherichia coli O157:H45 was first reported in Japan in 1998. This pathogen was classified as an enteropathogenic E. coli (EPEC) O157 because it was characterized by the Shiga toxin gene (stx)-negative and bundle-forming pilus (bfp) gene-positive genotypes. In this study, we investigated the type I...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.2000.tb02574.x

    authors： Abe A,Nagano H

    更新日期：2000-01-01 00:00:00

  • Overexpression of complement receptor type I (CR1, CD35) on erythrocytes in patients with hemoplasma infection.

    abstract：:In the present study, 12 patients with fever of undetermined origin, anemia and icterus were diagnosed with hemoplasma infection by light microscopy, transmission electron microscopy examination and PCR assay after being excluded from other usual febrile diseases. Complement receptor type I (CR1, CD35) expression on t...

    journal_title：Microbiology and immunology

    pub_type： 杂志文章

    doi：10.1111/j.1348-0421.2010.00240.x

    authors： Congbin Y,Aibin L,Congli Y,Juan X,Lanjun B,Weiping Z,Zhibiao Y,Xiuguo H

    更新日期：2010-08-01 00:00:00