Abstract：
PURPOSE OF INVESTIGATION:To compare the therapeutic and side effects of using Californium252 (252Cf) neutron brachytherapy with neoadjuvant intra-arterial embolism chemotherapy in combination with surgery for treating Stage Ib2-IIb cervical cancers (CCs). MATERIALS AND METHODS:Thirty-two Stage Ib2-IIb CC patients were enrolled and randomly divided into two groups from January 2007 to April 2010 in the present Hospital. Prior to surgery within four weeks, a total of 17 cases were treated with 252Cf neutron brachytherapy (700-800 cGy doses at point A) once a week (Group A), and 15 cases were treated by neoadjuvant intra-arterial embolism chemotherapy using a combination of bleomycin, carboplatin, and cyclophosphamide twice (Group B). The clinical symptoms and signs, side effects, and relapse condition follow up until July 2013 were compared between the two groups for the perioperation. RESULTS:Reductions in tumor mass and CR+PR were not significantly different between the groups before the surgery (p > 0.05). Abdominal pain and pelvic adhesions were significantly more severe in Group B (p < 0.05). There were no significant differences in surgical time, blood loss or the other side effects between Groups A and B (p > 0.05). The percentage of pelvic tumor recurrences in Group A was lower than that of the patients in Group B (11.8% vs 20.0%) although with no significant difference at present. No distant metastasis has been found in both two groups. CONCLUSION:Except for less abdominal pain and pelvic adhesions, 252Cf neutron brachytherapy has perioperative effects similar to those of neoadjuvant intra-arterial embolism chemotherapy.
journal_name
Eur J Gynaecol Oncoljournal_title
European journal of gynaecological oncologyauthors
Fei H,Ke P,Wang N,Shen H,Huang J,Tan J,Liang L,Song Xsubject
Has Abstractpub_date
2015-01-01 00:00:00pages
442-6issue
4eissn
0392-2936issn
2709-0086journal_volume
36pub_type
杂志文章,随机对照试验abstract：:Xanthogranulomas from the retroperitoneal space are rare. To our knowledge only a few cases have been reported in the literature in the retroperitoneal space. In this report, the authors present the case of a 24-year-old woman with a recurrence of this rare tumor. Two years after resection, the mass showed rapid local...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：AIM:The aim of this study was to determine the diagnostic value of thrombocytosis and high CA 125 levels in women with benign and malign adnexal masses. Thrombocytosis (platelet counts > 400 x 10(9)/l) has been identified as a poor prognostic factor in many cancers including certain gynecologic malignant tumors such as...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:The preceding platinum-based combination chemotherapy could possibly reduce tumor masses, allowing for adequate surgical debulking in advanced ovarian cancer. In this study, a total of 18 patients with peritoneal carcinomatosis of the ovary were evaluated between 1996 and 2003. All patients underwent open biopsy for t...
journal_title：European journal of gynaecological oncology
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Peritoneal cytology, obtained at the start of planned radical hysterectomy in 200 consecutive patients with Stage IB cervical cancer, none of whom had intra-abdominal extension of disease, was positive in only one patient; this patient received no adjuvant treatment and remains disease-free at 48 months. Routine perit...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Infection with high-risk human papillomavirus (hr-HPV) 16, 18, and 45 causes 94% of cervical carcinoma. In the present screening center the authors perform the hr-HPV test followed by Pap test to women aged 35-64 years if they result hr-HPV+. The authors' aimed to provide data regarding the genotyping test and eventua...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：:Ovarian yolk sac tumor (YST) is a malignant ovarian neoplasm differentiated from primordial germ cells that occur in young age, while endometrioid carcinoma (ECA) is a müllerian epithelial tumor that usually occurs in older patients. The coexistence of an ovarian ECA and YST component is very rare. Only 12 cases have ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:A combination therapy with gemcitabine and oxaliplatin (GEMOX) yielded a moderate activity in platinum-resistant ovarian cancers; however, frequent severe toxicities, such as thrombocytopenia and neurotoxicity, were observed. A certain modification of schedule might therefore facilitate the clinical applicat...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Vulvar dermatofibrosarcoma is a rare fibrous tumor of intermediate grade malignancy, with a tendency for local recurrence, and rarely metastasizes. Management should be multidisciplinary. This is a report of an apparently benign vulvar mass with delayed diagnosis of vulvar dermatofibrosarcoma. CASE REPORT:A...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:The diagnostic accuracy of an investigational test for cervix cancer screening is studied. The method involves a vaginal tampon that changes colour in relation to LDH activity and can detect preinvasive and invasive cervical lesions. The test was applied in 50 women with CIN, 50 women with histologically proved cervic...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Primitive omental leiomyomas are very rare. The primitive omental location of the leiomyoma is quite difficult to determine, with the possible presence of "parasite" myomas and of omental metastasizing myomas. Moreover, omental masses may be primitive or secondary metastasis from neoplasms. In this case report a primi...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:Twenty cases of ovarian carcinoma with normal-sized ovaries were examined histologically. Fifteen of them had metastatic disease of the peritoneal cavity and three of the remaining showed uterine involvement. Only in one case was the tumor confined to the ovary, but this patient had experienced systemic chemotherapy b...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Four patients with hypersensitivity reaction to carboplatin of variable severity, after previous uneventful cisplatin and carboplatin treatment, are described. Skin testing performed in two of the patients suggests a cross-reaction with cisplatin but was negative with carboplatin in one of them. The mechanism of hyper...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Ovarian tumors of low malignant potential (LMP) appear to be intermediate between adenomas and ovarian carcinomas. Such tumors are often associated with a significantly better prognosis than for ovarian carcinomas. However, a subset of LMPs can progress and become lethal even in patients with early-stage disease. In o...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:Lactic Dehydrogenase (LDH) serum levels were evaluated in three patients with ovarian dysgerminoma and LDH isoenzymes only in one of them. LDH serum levels were elevated at diagnosis and normal after therapy in all the patients; remained low in two patients in remission, increased in one at the moment of progression. ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：:Ductal carcinoma in situ (DCIS) represents a biologically and morphologically heterogeneous disease. It is characterized by a proliferation of presumably epithelial malignant cells confined within the lumens of the mammary ducts, without evidence of invasion beyond the basement membrane into the adjacent breast stroma...
journal_title：European journal of gynaecological oncology
pub_type： 历史文章,杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Exaggerated placental site is defined as a non-neoplastic trophoblastic lesion featuring exuberant infiltration into the endometrium and myometrium by intermediate trophoblasts and syncytiotrophoblasts. Exaggerated placental site can occur following normal or ectopic pregnancy, abortion, or hydatidiform mole. We encou...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:This paper reports an investigation of the mechanism involved in the response of endometrial adenocarcinoma to MPA. The following protocol was used for a period of 8 years: 1 g/day MPA per os for 30 days and 60 days after surgery, following by 500 mg/day for 1 year. Adenocarcinoma glycolytic activity, G-6-P cycle, pol...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:A new diagnostic method, technetium-99m-sestamibi scintigraphy, and its potential use in gynecological oncology is described. The biochemical mechanisms of uptake and retention of technetium-99m-sestamibi in neoplastic cells are presented and the grounds for the potential use of the tracer in predicting the response t...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:A phase II trial was conducted to further explore the potential of salvage intraperitoneal (IP) cisplatin-based therapy in patients with residual ovarian cancer. Twenty-five patients were treated with a regimen of cisplatin (75 mg/m2) and mitoxantrone (15 mg/m2) delivered IP every three weeks for a maximum of six cycl...
journal_title：European journal of gynaecological oncology
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Malignant mesothelioma of the peritoneum is a rare tumor that must be distinguished from the more common primary peritoneal serous epithelial neoplasms. We report a case of a 66-year-old female presenting with weight loss, anemia, and a large pelvic mass on ultrasound. At laparotomy a large (9 x 6.5 x 3.5 cm) mass in ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Transrectal ultrasonography is a new diagnostic method recently introduced in the study of normal and pathologic pelvis. The Authors describe their preliminary experience with the use of a rectal linear probe in the evaluation of the carcinoma of the cervix. This ultrasonographic method has resulted very useful in pro...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:We report the first case of bullous pemphigoid complicating radiation therapy for vulvar cancer. Shortly after completion of postoperative radiation therapy for a TIN1 vulvar carcinoma, the patient presented with a rash that started within, but continued to extend, well beyond the radiation field. A biopsy of the lesi...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to examine the prognostic significance of vascular endothelial growth factor (VEGF) in epithelial ovarian cancer (EOC). METHODS:Surgical specimens of 105 patients with primary EOC FIGO Stages 1 to 4, who underwent surgical staging, were investigated. Expression of VEGF was evaluate...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:Changes in CA 125 antigen concentration and serum half-life were determined in 63 women with ovarian carcinoma during chemotherapy following various types of surgery. Concentration of CA 125 in serum correlated with the degree of clinical advancement of the tumor, 20.00 and 688.84 U per ml at stages I, II, and IV, res...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:More and more malignancies are identified by laparoscopy. Concerns have been risen about the safety of these procedures, especially after the publications on trocar metastases. General laparoscopic techniques should include safety measures in order to reduce the risk of implantation metastasis. ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:To establish the accuracy of endometrial biopsy with the Cornier pipelle in the diagnosis of endometrial cancer and atypical endometrial hyperplasia in our milieu. MATERIAL AND METHOD:We reviewed 1,535 anatomopathologic reports on endometrial biopsies taken from outpatients using the Cornier pipelle between ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：AIM:Examination of the potential role of leptin in the development of uterine myomas. Expression of the leptin gene and leptin receptor gene was tested in the myometrium of healthy women, and in myomas and the surrounding myometrium of women with benign tumors. METHODS:Using RT-PCR, expression of the leptin gene and l...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:To determine the safety of omitting routine interval laboratory assessments, dietary restrictions, and isolation precautions between cycles of chemotherapy for gynecologic malignancies. METHODS:Data were retrospectively obtained from the records of women receiving chemotherapy for gynecologic cancer from July ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:We aimed to investigate the utility and efficacy of the Keyes skin biopsy instrument for cervical biopsy procedures. MATERIAL AND METHODS:A prospective clinical trial was conducted on 50 women with cervical lesions. Colposcopy-guided cervical biopsies were collected using a Keyes biopsy punch and a Kevorkian...
journal_title：European journal of gynaecological oncology
pub_type： 临床试验,杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:A phyllodes tumor is a rare breast neoplasm, and in the majority of cases is benign. Its diagnosis is difficult because many characteristics of this neoplasm are also typical for other changes within the breast, especially for fibroadenoma. Palpable examination and imaging diagnostics are obviously very important in t...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
