Abstract:
:It has been known for many decades that multiple abnormalities of the autonomic nervous system (ANS) are present in heart failure (HF). Moreover, many of the effective therapies currently used to treat HF have either direct or indirect effects on the ANS. While therapies that block over-activity of the sympathetic nervous system are now standard of care, much less well studied are therapies aimed at augmenting the parasympathetic nervous system. This review will cover recent and ongoing investigations targeting modulation of the ANS, especially highlighting new and ongoing studies directed toward augmenting parasympathetic mechanisms.
journal_name
Curr Cardiol Repjournal_title
Current cardiology reportsauthors
Dunlap ME,Bhardwaj A,Hauptman PJdoi
10.1007/s11886-015-0652-2subject
Has Abstractpub_date
2015-11-01 00:00:00pages
103issue
11eissn
1523-3782issn
1534-3170pii
10.1007/s11886-015-0652-2journal_volume
17pub_type
杂志文章,评审abstract::Viable treatment options for advanced heart failure have not emerged as the number of people afflicted with this condition has grown. Although heart transplantation is the only curative strategy for patients with end-stage heart failure, the relative shortage of donors has led to a worldwide plateau of this option ove...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-014-0468-5
更新日期:2014-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This review discusses the benefits of a completely percutaneous approach to endovascular aortic aneurysm repair (EVAR), and provides an outline as to how this is performed by a multidisciplinary team of cardiologists and cardiovascular surgeons at a quaternary care community hospital. RECENT FINDINGS...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-018-1023-6
更新日期:2018-07-26 00:00:00
abstract::Imaging with radionuclides has historically played an important role in detection of cardiovascular disease as well as in risk stratification and prognostication. With the growth of molecular biology have come new therapeutic interventions and the requirement for new diagnostic imaging approaches. Noninvasive targeted...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-005-0025-3
更新日期:2005-03-01 00:00:00
abstract::Gut microbiota has been recently established to have a contributory role in the development of cardiometabolic disorders, such as atherosclerosis, obesity, and type 2 diabetes. Growing interest has focused on the modulation of gut microbiota as a therapeutic strategy in cardiovascular diseases and metabolic disorders....
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-015-0671-z
更新日期:2015-12-01 00:00:00
abstract::Patients from racial and ethnic minorities experience higher mortality after cardiac surgery compared to white patients, both during the early postoperative phase as well as long term. A number of factors likely explain poor outcomes in black and minority patients, which include differences in biology, comorbid health...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-015-0587-7
更新日期:2015-05-01 00:00:00
abstract::Aldosterone is the principal circulating mineralocorticoid in humans, and aldosterone synthesis normally occurs in the face of volume depletion and renin stimulation. In primary and secondary aldosteronism, aldosterone synthesis continues despite volume expansion and causes hypertension. Other steroid hormones that ar...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-005-0059-6
更新日期:2005-11-01 00:00:00
abstract::Although clinical evidence indicates that many of the electrophysiologic and functional changes associated with atrial fibrillation (AF) can be reversed by maintaining normal sinus rhythm (NSR), a series of large-scale randomized trials failed to demonstrate that this strategy provides a survival advantage. These stud...
journal_title:Current cardiology reports
pub_type: 杂志文章
doi:10.1007/s11886-006-0078-y
更新日期:2006-09-01 00:00:00
abstract::A number of reports demonstrate the importance of serum triglyceride values in predicting the clinical onset of vascular disease. However, adjustment for measurements highly correlated with triglyceride (TG) levels, such as history of diabetes, body mass index, and high-density lipoprotein cholesterol (HDL-C), lessen ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-001-0060-7
更新日期:2001-09-01 00:00:00
abstract::Hypertension in patients with renovascular disease poses a major clinical challenge. Renal arterial disease accelerates hypertension by activation of multiple pressor systems. Although younger individuals with fibromuscular lesions often respond well to angioplasty with minor associated risks, care must be taken in ca...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/BF02938389
更新日期:2007-11-01 00:00:00
abstract::Hypertension is highly prevalent affecting nearly one third of the US adult population. Though generally approached as an outpatient disorder, elevated blood pressure is observed in a majority of hospitalized patients. The spectrum of hypertensive disease ranges from patients with hypertensive emergency including mark...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-015-0648-y
更新日期:2015-11-01 00:00:00
abstract::Aortic stenosis affects many people worldwide with a significant impact on morbidity and mortality with uncorrected, symptomatic aortic valve stenosis carrying mortality of 50% at one year. Degenerative calcific pathology, the most common cause of aortic stenosis, increases in prevalence with age; estimated prevalence...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-013-0367-1
更新日期:2013-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Ocular perfusion pressure (OPP) is defined as the difference between BP and intraocular pressure (IOP). With low BP comes low OPP and resultant ischemic damage to the optic nerve, leading to glaucoma progression. The purpose of this article is to review the literature on BP as it relates to glaucoma a...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-017-0927-x
更新日期:2017-09-19 00:00:00
abstract::Patients with diabetes mellitus are at particularly high risk for cardiovascular disease. Although global risk factor scoring systems, such as the Framingham Risk Score, are well established for screening asymptomatic adults, they are not as predictive in diabetics. Therefore, there has been considerable interest in n...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-013-0358-2
更新日期:2013-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The present review aims to discuss the recent advances in surgical management of spontaneous intracerebral hemorrhage (ICH), safety and efficacy of minimally invasive surgical techniques, and the existing evidence supporting their use. RECENT FINDINGS:Newer surgical techniques, collectively referred ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-018-1078-4
更新日期:2018-10-11 00:00:00
abstract::The heart and kidney interact in terms of hemodynamics and neurohumoral regulatory mechanisms, and this helps to maintain circulatory homeostasis under normal conditions. However, the normal regulatory mechanisms become inappropriate in the setting of congestive heart failure (CHF), and significant renal dysfunction o...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-012-0258-x
更新日期:2012-06-01 00:00:00
abstract::Although overall stroke incidence has been declining in developed countries, there is evidence that stroke in the young is increasing. Increasing incidence may be particularly pronounced among minorities in whom historically a higher burden of stroke has been reported. Compared with older adults, time spent with disab...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-013-0421-z
更新日期:2013-12-01 00:00:00
abstract::Heart failure management is complex and costly. Genetic variations that alter drug absorption, metabolism, and receptor-ligand interactions have the potential to modify drug response and safety. Evidence shows that genetic factors interact with numerous heart failure medications, including vasodilators, beta blockers,...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-008-0031-3
更新日期:2008-05-01 00:00:00
abstract::Selective coronary angiography was originally performed through open brachial arteriotomy. Thereafter, the percutaneous Seldinger technique and the use of preformed Judkins-type catheters popularized the femoral approach. More recently, after the first report of successful coronary angiography by the transradial appro...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-009-0054-4
更新日期:2009-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Real-time 3-dimensional (3-D) imaging of cardiovascular injury and regeneration remains challenging. We introduced a multi-scale imaging strategy that uses light-sheet illumination to enable applications of cardiovascular injury and repair in models ranging from zebrafish to rodent hearts. RECENT FIN...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-018-0979-6
更新日期:2018-03-24 00:00:00
abstract:PURPOSE OF REVIEW:The aim of low-density lipoprotein-cholesterol (LDL-C) lowering therapies is to safely achieve a consistent and long-term reduction in exposure of the vasculature to atherogenic lipoproteins in order to reduce the risk of atherosclerotic cardiovascular (CV) disease and the associated CV events, such a...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01427-6
更新日期:2020-10-21 00:00:00
abstract::The accurate differentiation of viable and nonviable myocardium is crucial for therapy planning in patients with coronary artery disease and left ventricular dysfunction. Traditional techniques such as echocardiography, positron emission tomography, single photon emission computed tomography, and dobutamine echocardio...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-005-0012-8
更新日期:2005-01-01 00:00:00
abstract::Management of severe chronic mitral regurgitation (MR) in severe heart failure is challenging. There are controversies over the efficacy of surgical correction of MR in the presence of severely depressed left ventricular (LV) function. The etiology of MR plays an important role in clinical decision making. In organic ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-006-0038-6
更新日期:2006-05-01 00:00:00
abstract::Thrombolytic therapy aims to achieve rapid and sustained infarct-related artery patency, although this results in a procoagulant state. Heparin has limitations as an antithrombin agent, which has led to clinical investigation of alternative agents. Direct thrombin inhibitors, as adjuncts to thrombolytic therapy, have ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-999-0021-0
更新日期:1999-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Cardiovascular magnetic resonance (CMR) provides the most comprehensive imaging assessment of pericardial disease, providing a three-dimensional assessment of the pericardium, functional assessment of its impact on cardiac contractility, and pericardial tissue/fluid characterization. This review prese...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01392-0
更新日期:2020-09-15 00:00:00
abstract::Diabetes mellitus (DM) is a metabolic disorder of multiple etiologies that causes long-term damage of various organs including the cardiovascular system. A consistent observation shows that DM amplifies the risk of cardiovascular events by 4- to 6-fold. Since coronary artery disease (CAD) in diabetic patients exhibits...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-012-0323-5
更新日期:2013-01-01 00:00:00
abstract::Innate differences in gender physiology result in unique exposures, risk, and protection that are specific to women. Recognition and appreciation of these differences results in better treatment adaptations for women and better outcomes. Disparities between genders in the treatment of major cardiovascular risk factors...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-010-0135-4
更新日期:2010-11-01 00:00:00
abstract::Cardiovascular magnetic resonance (CMR) is widely regarded as capable of providing a cornucopia of detailed diagnostic information. However, of that information, very little is truly unique, and can be obtained by a combination of alternate diagnostic modalities. Given this, it is anticipated that in the short term (1...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-004-0067-y
更新日期:2004-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Acute pulmonary embolism (PE) is a common condition associated with high morbidity and mortality. Prior studies have evaluated the role of systemic fibrinolysis and catheter-directed therapy (CDT) in the management of PE. In this review, we examine current data on risk stratification and the appropria...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-017-0864-8
更新日期:2017-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To review methodological and logistical aspects of CT myocardial perfusion, current clinical evidence and possible future directions, with specific focus on use in patients with coronary artery disease (CAD). RECENT FINDINGS:CT myocardial perfusion imaging may be performed as an add-on to standard co...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-017-0937-8
更新日期:2017-10-25 00:00:00
abstract:PURPOSE OF REVIEW:The aim of the present manuscript is to review the latest advancements of radionuclide molecular imaging in the diagnosis and prognosis of individuals with cardiac amyloidosis. RECENT FINDINGS:99mTechnetium labeled bone tracer scintigraphy had been known to image cardiac amyloidosis, since the 1980s;...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-017-0868-4
更新日期:2017-07-01 00:00:00