Abstract:
BACKGROUND:Little is known about sex-specific risk for nonmedical prescription opioid use (NMPOU) and DSM-5 nonmedical prescription opioid use disorder (NMPOUD). The objective of the present study was to present prevalence, correlates, psychiatric comorbidity, treatment and disability of NMPOU and DSM-5 NMPOUD among men and women. METHODS:Nationally representative sample of the U.S. RESULTS:Prevalences of 12-month and lifetime NMPOU were greater among men (4.4%, 13.0%) than women (3.9%, 9.8%), while corresponding rates of DSM-5 NMPOUD did not differ between men (0.9%, 2.2%) and women (0.9%, 1.9%). Regardless of time frame and sex, NMPOU and NMPOUD generally decreased with age and were lower among Blacks, Asians/Pacific Islanders and Hispanics, and respondents with lower socioeconomic status. Among men with NMPOU, rates were lower among respondents in the Northeast and South and among those previously married (lifetime). Across time frames and gender, NMPOU and NMPOUD were generally associated with other substance use disorders, posttraumatic stress and borderline, schizotypal and antisocial personality disorders, but associated with major depressive disorder, persistent depression and bipolar I disorder only among men. Disability increased with NMPOU frequency and NMPOUD severity. Only 7.6% and 8.2% of men and women with NMPOU ever received treatment, while 26.8% and 31.1% ever received treatment for NMPOUD. CONCLUSIONS:NMPOU and NMPOUD are highly disabling, associated with a broad array of sex-specific and shared correlates and comorbidities and largely go untreated in the U.S. Valid assessment tools are needed that include gender as a stratification variable to identify NMPOU and NMPOUD.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Kerridge BT,Saha TD,Chou SP,Zhang H,Jung J,Ruan WJ,Smith SM,Huang B,Hasin DSdoi
10.1016/j.drugalcdep.2015.08.026subject
Has Abstractpub_date
2015-11-01 00:00:00pages
47-56eissn
0376-8716issn
1879-0046pii
S0376-8716(15)01619-1journal_volume
156pub_type
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pub_type: 杂志文章,meta分析,评审
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更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-01-15 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2012.08.014
更新日期:2013-02-01 00:00:00
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更新日期:2004-02-07 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-10-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
abstract::The relationship between the effect of citalopram on alcohol intake and central serotonergic neurotransmission, as assessed by prolactin (PRL) response to fenfluramine, was investigated in 17 male heavy drinkers. A positive correlation was obtained, suggesting that the status of central serotonergic neurotransmission ...
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pub_type: 杂志文章
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更新日期:2001-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-09-01 00:00:00