Abstract:
BACKGROUND/AIMS:Gastroparesis-like syndrome (GLS) is defined as gastroparesis-like symptoms with normal gastric scintigraphy. While the efficacy of gastric electrical stimulation (GES) in gastroparesis is well known, the utility of GES in GLS is largely unknown. Our aim was to clarify the role of GES in GLS. We implanted consecutive patients with symptoms of gastroparesis with temporary gastric electrical stimulation and observed changes in gastric scintigraphy and total symptom score. METHODS:Five hundred and fifty-one patients suffering from symptoms of gastroparesis (nausea, vomiting, bloating/distension, anorexia/early satiety, and abdominal pain) with negative endoscopy underwent gastric scintigraphy with analysis of 1) solid radionuclide gastric emptying at 1, 2, and 4 hours (% remaining); 2) area under the gastric emptying curve (AUC) at 1, 2, and 4 hours; and 3) total gastric emptying test (GET) (the sum of 1, 2, and 4 hour values). Patients were stratified into: delayed gastric emptying, normal gastric emptying, and rapid gastric emptying (Appendix). Of the 551 patients in the larger cohort, 379 had implantation of temporary gastric electrical stimulation (tGES). Gastrointestinal symptoms and gastric emptying were com - pared pre and post tGES implantation. RESULTS:After tGES, 2 hour gastric retention decreased (P < 0.01) for the delayed patients, and increased (P < 0.001) for normal and rapid patients. These changes were accompanied by improvements (P < 0.001) in vomiting, nausea, and total symptom scores in all 3 subgroups. CONCLUSIONS:Gastric electrical stimulation may be an effective therapy for treating the symptoms of gastroparesis with normal gastric emptying. Further exploration of endoscopic electrical stimulation as a treatment for gastroparesis-like symptoms with non-delayed gastric emptying is needed.
journal_name
J Neurogastroenterol Motiljournal_title
Journal of neurogastroenterology and motilityauthors
Singh S,McCrary J,Kedar A,Weeks S,Beauerle B,Weeks A,Endashaw O,Lahr C,Starkebaum W,Abell Tdoi
10.5056/jnm15046subject
Has Abstractpub_date
2015-10-01 00:00:00pages
520-7issue
4eissn
2093-0879issn
2093-0887pii
jnm15046journal_volume
21pub_type
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2012.18.4.399
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2011.17.4.402
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm15096
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm17047
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2011.17.2.140
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2013.19.4.495
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journal_title:Journal of neurogastroenterology and motility
pub_type: 评审
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2012.18.1.70
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2011.17.3.279
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