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CAMWI: Detecting protein complexes using weighted clustering coefficient and weighted density.

Abstract：

:Detection of protein complexes is very important to understand the principles of cellular organization and function. Recently, large protein-protein interactions (PPIs) networks have become available using high-throughput experimental techniques. These networks make it possible to develop computational methods for protein complex detection. Most of the current methods rely on the assumption that protein complex as a module has dense structure. However complexes have core-attachment structure and proteins in a complex core share a high degree of functional similarity, so it expects that a core has high weighted density. In this paper we present a Core-Attachment based method for protein complex detection from Weighted PPI Interactions using clustering coefficient and weighted density. Experimental results show that the proposed method, CAMWI improves the accuracy of protein complex detection.

journal_name

Comput Biol Chem

journal_title

Computational biology and chemistry

authors

Lakizadeh A,Jalili S,Marashi SA

doi

10.1016/j.compbiolchem.2015.07.012

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

231-40

eissn

1476-9271

issn

1476-928X

pii

S1476-9271(15)30094-3

journal_volume

58

pub_type

杂志文章

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