Abstract:
:The development of robust and straightforward methods to efficiently label aromatic moieties starting from simple and convenient radio-synthetic sources still represents a considerable challenge. In this report, a new palladium-catalyzed decarboxylative cyanation protocol has been described. This procedure utilizes [(14)C]-labeled potassium cyanide, one of the simplest and commercially available sources of carbon-14. Under the optimized reaction conditions, a series of [(13)C] and [(14)C]-aromatic nitriles were easily prepared (12-74% yield starting from potassium cyanide). The usefulness of this methodology is highlighted by a rare example of a formal two-step [(12)C]-[(14)C] carbon isotope exchange. The current synthetic approach may represent a promising alternative to traditional preparations of relevant building blocks such as labeled aromatic nitriles.
journal_name
J Labelled Comp Radiopharmjournal_title
Journal of labelled compounds & radiopharmaceuticalsauthors
Loreau O,Georgin D,Taran F,Audisio Ddoi
10.1002/jlcr.3330subject
Has Abstractpub_date
2015-09-01 00:00:00pages
425-8issue
11-12eissn
0362-4803issn
1099-1344journal_volume
58pub_type
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journal_title:Journal of labelled compounds & radiopharmaceuticals
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