当前位置： SCI文献检索 > Orthopaedic Surgery期刊下所有文献 > Intra-articular Adjuvant Analgesics following Knee Arthroscopy: Comparison between Single and Double Dose Dexmedetomidine and Ropivacaine A Multicenter Prospective Double-blind Trial.

Intra-articular Adjuvant Analgesics following Knee Arthroscopy: Comparison between Single and Double Dose Dexmedetomidine and Ropivacaine A Multicenter Prospective Double-blind Trial.

Abstract：

OBJECTIVE:Knee arthroscopy is a commonly performed orthopedic procedure. Post-operatively, adequate pain relief reduces the surgical stress response and patient's morbidity and facilitates rehabilitation. The analgesic effect of dexmedetomidine (2 μg/kg body weight) as an adjunct to ropivacaine in knee arthroscopic knee procedures was studied to determine whether this would achieve longer post-operative analgesia and whether the study dosage of dexmedetomidine was safe and free of adverse effects. PATIENTS AND METHODS:In a multicenter prospective double blind trial of sixty patients undergoing knee arthroscopic procedures, patients were randomly assigned to three groups: Group R, receiving intra-articular ropivacaine (20 mL); Group D1 (18 mL ropivacaine, dexmedetomidine 1 μg/kg body weight); and Group D2 (18 mL ropivacaine, dexmedetomidine 2 μg/kg). RESULTS:Group D2 had significantly lower pain scores for the first 12 postoperative hours than Group D1 and Group R. Time to first analgesic requirement was longest in Group D2 (757.30 ± 207.68 min), followed by Group D1 (433.2 ± 54.3 min) and Group R (311.80 ± 61.56 min); these differences were significant (P < 0.05). Total analgesic requirement was significantly lower in Group D2 (82.50 ± 48.05 mg; P < 0.05). Intensity of pain was significantly less in Group D2 in the third (P < 0.01) and sixth hours (P < 0.05). CONCLUSION:Intra-articular dexmedetomidine (2 μg/kg) has superior analgesic efficacy, delayed the first postoperative requirement for analgesia and decreasing the need for postoperative analgesics with no major adverse effects.

journal_name

Orthop Surg

journal_title

Orthopaedic surgery

authors

Panigrahi R,Roy R,Mahapatra AK,Prasad A,Priyadarshi A,Palo N

doi

10.1111/os.12182

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

250-5

issue

3

eissn

1757-7853

issn

1757-7861

journal_volume

7

pub_type

杂志文章,多中心研究,随机对照试验

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