Abstract：
:The extensive and unregulated use of antibacterial drugs in animal farms in Lebanon can lead to detrimental consequences for the public health. To monitor the levels of sulfonamides and their metabolites in farms in Lebanon, a total of 304 meat samples were collected and analyzed using liquid chromatography coupled to triple quadrupole and hybrid linear ion trap-Orbitrap mass spectrometry following QuEChERS-based extraction. Sulfonamide residues could be detected in forty-six samples, ten of which contained a concentration of sulfaquinoxaline (151.4-1196.7 μg kg(-1) in chicken samples) and sulfadiazine (109.8 μg kg(-1) in a beef sample) exceeding the European Union-based maximum residue level by 1-12 folds, and thus were unfit for human consumption. Several acetylated, hydroxylated, and/or sulfated metabolites were identified, some of which were not previously detected in edible tissues. Most identified metabolites exhibited potential toxicity equivalent or higher than that of the parent molecule as estimated by in silico tests.
journal_name
Food Chemjournal_title
Food chemistryauthors
Hiba A,Carine A,Haifa AR,Ryszard L,Farouk Jdoi
10.1016/j.foodchem.2015.06.093subject
Has Abstractpub_date
2016-02-01 00:00:00pages
212-27eissn
0308-8146issn
1873-7072pii
S0308-8146(15)00985-1journal_volume
192pub_type
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