Abstract:
:We introduce a non-invasive approach for optogenetic regulation in biological cells through highly scattering skull tissue using wavefront shaping. The wavefront of the incident light was systematically controlled using a spatial light modulator in order to overcome multiple light-scattering in a mouse skull layer and to focus light on the target cells. We demonstrate that illumination with shaped waves enables spatiotemporal regulation of intracellular Ca(2+) level at the individual-cell level.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yoon J,Lee M,Lee K,Kim N,Kim JM,Park J,Yu H,Choi C,Heo WD,Park Ydoi
10.1038/srep13289subject
Has Abstractpub_date
2015-08-21 00:00:00pages
13289issn
2045-2322pii
srep13289journal_volume
5pub_type
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