Optogenetic control of cell signaling pathway through scattering skull using wavefront shaping.

Abstract:

:We introduce a non-invasive approach for optogenetic regulation in biological cells through highly scattering skull tissue using wavefront shaping. The wavefront of the incident light was systematically controlled using a spatial light modulator in order to overcome multiple light-scattering in a mouse skull layer and to focus light on the target cells. We demonstrate that illumination with shaped waves enables spatiotemporal regulation of intracellular Ca(2+) level at the individual-cell level.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Yoon J,Lee M,Lee K,Kim N,Kim JM,Park J,Yu H,Choi C,Heo WD,Park Y

doi

10.1038/srep13289

subject

Has Abstract

pub_date

2015-08-21 00:00:00

pages

13289

issn

2045-2322

pii

srep13289

journal_volume

5

pub_type

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