Amyloidoma secondary to insulin injection: Cytologic diagnosis and pitfalls.

Abstract:

:Amyloidomas are rare tumors composed of deposits of amyloid protein not associated with systemic amyloidosis. They can present as an initial manifestation of a systemic disease process or can be a completely localized phenomenon. We present a case of amyloidoma associated with insulin injection site found incidentally in an 80-year-old male with multiple co-morbidities who presented with diverticulitis associated bleeding. A subcutaneous abdominal mass was found on physical examination. Imaging revealed a 5 cm × 1.6 cm homogenous subcutaneous lesion. A fine-needle aspiration (FNA) and core biopsy were performed under ultrasound guidance to reveal amorphous material proven to be amyloidosis at insulin injection sites (AIns) type amyloid. The patient had no treatment for this lesion and has had his care triaged to his more serious health problems. This is the first case of AIns type amyloidoma associated with insulin injection site reported in cytology literature. We highlight the cytologic findings and diagnostic pitfalls. As the incidence of diabetes is increasing, cytopathologists may encounter this lesion more often on FNA.

journal_name

Cytojournal

journal_title

CytoJournal

authors

Grunes D,Rapkiewicz A,Simsir A

doi

10.4103/1742-6413.161602

subject

Has Abstract

pub_date

2015-07-28 00:00:00

pages

15

eissn

0974-5963

issn

1742-6413

pii

CJ-12-15

journal_volume

12

pub_type

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