Abstract:
:Organ transplantation can offer a curative option for patients with end stage organ failure. Unfortunately the treatment is severely limited by the availability of donor organs. Organ bioengineering could provide a solution to the worldwide critical organ shortage. The majority of protocols to date have employed the use of decellularization-recellularization technology of naturally occurring tissues and organs with promising results in heart, lung, liver, pancreas, intestine and kidney engineering. Successful decellularization has provided researchers with suitable scaffolds to attempt cell reseeding. Future work will need to focus on the optimization of organ specific recellularization techniques before organ bioengineering can become clinically translatable. This review will examine the current progress in organ bioengineering and highlight future challenges in the field.
journal_name
Bioengineeredjournal_title
Bioengineeredauthors
Welman T,Michel S,Segaren N,Shanmugarajah Kdoi
10.1080/21655979.2015.1081320subject
Has Abstractpub_date
2015-01-01 00:00:00pages
257-61issue
5eissn
2165-5979issn
2165-5987journal_volume
6pub_type
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