Abstract:
:Age-related increase in frailty is accompanied by a fundamental shift in cellular iron homeostasis. By promoting oxidative stress, the intracellular accumulation of non-heme iron outside of binding complexes contributes to chronic inflammation and interferes with normal brain metabolism. In the absence of direct non-invasive biomarkers of brain oxidative stress, iron accumulation estimated in vivo may serve as its proxy indicator. Hence, developing reliable in vivo measurements of brain iron content via magnetic resonance imaging (MRI) is of significant interest in human neuroscience. To date, by estimating brain iron content through various MRI methods, significant age differences and age-related increases in iron content of the basal ganglia have been revealed across multiple samples. Less consistent are the findings that pertain to the relationship between elevated brain iron content and systemic indices of vascular and metabolic dysfunction. Only a handful of cross-sectional investigations have linked high iron content in various brain regions and poor performance on assorted cognitive tests. The even fewer longitudinal studies indicate that iron accumulation may precede shrinkage of the basal ganglia and thus predict poor maintenance of cognitive functions. This rapidly developing field will benefit from introduction of higher-field MRI scanners, improvement in iron-sensitive and -specific acquisition sequences and post-processing analytic and computational methods, as well as accumulation of data from long-term longitudinal investigations. This review describes the potential advantages and promises of MRI-based assessment of brain iron, summarizes recent findings and highlights the limitations of the current methodology.
journal_name
Neuropsychol Revjournal_title
Neuropsychology reviewauthors
Daugherty AM,Raz Ndoi
10.1007/s11065-015-9292-ysubject
Has Abstractpub_date
2015-09-01 00:00:00pages
272-87issue
3eissn
1040-7308issn
1573-6660journal_volume
25pub_type
杂志文章,评审abstract::Over the past few decades, research has established that the cerebellum is involved in executive functions; however, its specific role remains unclear. There are numerous theories of cerebellar function and numerous cognitive processes falling under the umbrella of executive function, making investigations of the cere...
journal_title:Neuropsychology review
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journal_title:Neuropsychology review
pub_type: 杂志文章,meta分析
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journal_title:Neuropsychology review
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journal_title:Neuropsychology review
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journal_title:Neuropsychology review
pub_type: 杂志文章,评审
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journal_title:Neuropsychology review
pub_type: 杂志文章,评审
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journal_title:Neuropsychology review
pub_type: 历史文章,杂志文章,评审
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journal_title:Neuropsychology review
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journal_title:Neuropsychology review
pub_type: 杂志文章,评审
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journal_title:Neuropsychology review
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journal_title:Neuropsychology review
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journal_title:Neuropsychology review
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