Abstract：
INTRODUCTION:Several bioactive bioceramics with osteoconductive effects can inhibit osteoclast formation and bone resorption in vitro, but the exact underlying mechanism has not been fully elucidated. Bioaggregate (BA), a novel calcium silicate nanoparticulate bioceramic, significantly induces bone and periodontal regeneration. In this study, we aimed to explore the effect of BA extracts on osteoclastogenesis and bone resorption. METHODS:The RAW264.7 cells were treated with soluble receptor activator of nuclear factor kappa B ligand to osteoclastogenesis. BA extracts were used to investigate the effect of BA on osteoclast differentiation, fusion, and bone resorption. Furthermore, the ions in BA extracts were quantitatively analyzed. Finally, the key molecules in the receptor activator of nuclear factor kappa B ligand-RANK signaling pathway, including receptor activator of nuclear factor κB (RANK), tumor necrosis factor receptor associated factor 6 (TRAF6), nuclear factor-kappa B (NF-κB), and nuclear factor of activated T cells c1 (NFATc1), were explored. RESULTS:BA suppressed osteoclastogenesis and bone resorption in vitro. BA releases Si ions and a small amount of Sr ions and provides alkalinity. Treatment with BA extracts decreased the migration ability and fusion of RAW264.7 cells. We also observed that BA causes a significantly decreased expression of RANK, TRAF6, NF-κB, and NFATc1. CONCLUSIONS:Our study provides further insight into the mechanism by which calcium silicate-based bioceramics inhibit osteoclastogenesis and bone resorption and also suggests that BA is a useful material for several clinical situations because it both stimulates osteoblast differentiation and inhibits osteoclast formation.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
Tian J,Qi W,Zhang Y,Glogauer M,Wang Y,Lai Z,Jiang Hdoi
10.1016/j.joen.2015.05.018subject
Has Abstractpub_date
2015-09-01 00:00:00pages
1500-6issue
9eissn
0099-2399issn
1878-3554pii
S0099-2399(15)00504-Xjournal_volume
41pub_type
杂志文章abstract：:Amalgam, IRM, and a mineral trioxide aggregate were tested for repair of experimentally created root perforations. Fifty sound, extracted mandibular and maxillary molars were used in this study. A perforation was created on the mesial root surface at about a 45-degree angle to the long axis of each tooth. The tooth wa...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(06)81282-3
更新日期：1993-11-01 00:00:00
abstract：INTRODUCTION:Optical coherence tomography (OCT) is a noninvasive modality to obtain in-depth images of biological structures. A dental OCT system has become available for chairside application. This in vitro study hypothesized that swept-source OCT can be used to measure the remaining dentin thickness (RDT) at the roof...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2015.03.016
更新日期：2015-08-01 00:00:00
abstract：:Apical periodontitis and its concomitant periapical osteolysis is caused by pulpal infection, and bacterial lipopolysaccharide (LPS) is known to play a major role in the bone resorption process. Little is known concerning the effect of root canal intervisit dressings on residual LPS in root canals after bacterial cell...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(06)81199-4
更新日期：1993-02-01 00:00:00
abstract：INTRODUCTION:The radicular groove is clinically significant due to its relevance to onset of inflammatory processes in the periodontal tissues. This study examined anatomic features of radicular grooves by using micro-computed tomography (micro-CT) scans. METHODS:Eleven extracted permanent maxillary lateral incisors w...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2011.03.002
更新日期：2011-06-01 00:00:00
abstract：INTRODUCTION:Electronic working length measurement during root canal treatment in teeth with enlarged apical foramina is a challenge. The aims of this in vitro study were (1) to assess the influence of foramen widening on the accuracy of 5 different electronic foramen locators (EFLs) and (2) to compare the accuracy of ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2013.09.032
更新日期：2014-01-01 00:00:00
abstract：:This report documents the case of a patient who developed neuropathy that presented as dental pain and was later diagnosed with Lyme disease. A healthy female patient presented to the endodontist with toothache symptoms. Her symptoms included intense pain in the left mandible irradiating into the temporalis area and t...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2020.06.011
更新日期：2020-09-01 00:00:00
abstract：INTRODUCTION:Root resorption is a common complication after replantation following traumatic dental avulsion. Endodontic therapy combined with local and intracanal medications aims to avoid osteoclastic activity. In such cases, the application of alendronate (ALN), a bisphosphonate widely used for the treatment of bone...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2014.07.010
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:Root canal therapy is a highly successful in-office treatment and preventive measure against periapical abscesses. Left untreated, periapical abscesses can have serious consequences that can lead to hospitalization. This study observes the trends of hospitalizations attributed to periapical abscesses. MET...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2013.04.042
更新日期：2013-09-01 00:00:00
abstract：:The Editorial Board of the Journal of Endodontics has developed a literature-based study guide of topical areas related to endodontics. This study guide is intended to give the reader a focused review of the essential endodontic literature and does not cite all possible articles related to each topic. Although citing ...
journal_title：Journal of endodontics
pub_type： 杂志文章,评审
doi：10.1016/j.joen.2007.11.007
更新日期：2008-05-01 00:00:00
abstract：INTRODUCTION:Calcium hydroxide (CH) and nano-calcium hydroxide (NCH) as intracanal medicaments may affect the physical and chemical properties of dentin. The aim of this investigation was to evaluate the effects of CH and NCH on the microhardness and superficial chemical structure of radicular dentin. METHODS:In this ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2019.06.002
更新日期：2019-09-01 00:00:00
abstract：:The purpose of this study was to investigate histologically and histometrically the changes in pulpal and periapical tissues after pulpal exposure in rats. All animals received a pulpal exposure in the left mandibular first molar. Animals were killed at 1 to 56 days after pulpal exposure, and their mandibles were eval...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/s0099-2399(06)80020-8
更新日期：1994-01-01 00:00:00
abstract：INTRODUCTION:Different single-file systems are available for endodontic treatment; however, comparative studies are scarce. Thus, the present study evaluated bacterial reduction promoted by 2 single-file systems: Wave One (Dentsply Maillefer, Ballaigues, Switzerland) and One Shape (Micromega, Besancon, France). METHOD...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2014.07.024
更新日期：2014-12-01 00:00:00
abstract：:This study assessed in vitro the diagnostic ability of cone beam computed tomography (CBCT) scans with different voxel resolutions in the detection of simulated external root resorption (ERR). For that purpose, 59 teeth were viewed through iCAT tomography (Imaging Sciences International, Inc, Hatfield, PA) following t...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2008.11.005
更新日期：2009-02-01 00:00:00
abstract：INTRODUCTION:Microorganisms are able to survive and cause persistent infection in the extraradicular area. The aims of this study were to investigate the primary bacterial flora and the localization of extraradicular biofilm in persistent apical periodontitis lesions. METHODS:Apical root samples from root-end surgery ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2012.03.004
更新日期：2012-07-01 00:00:00
abstract：INTRODUCTION:This study evaluated the cyclic fatigue resistance (CFR) of Reciproc (R25 and R40; VDW, Munich, Germany) and Reciproc Blue (R25 and R40, VDW) instruments used in an artificial S-shaped canal. METHODS:A total of 80 files were tested in an S-shaped canal (n = 20 for each file, Reciproc R25 and R40 and Recip...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2017.04.009
更新日期：2017-10-01 00:00:00
abstract：:There is an increasing interest in the utility of dental pulp stem cells (DPSCs) for dentin regeneration. The mechanisms involved in DPSC differentiation remain poorly understood. The purpose of the study was to investigate the mineralization capacity of human dental pulp cells (DPCs) and identify potential markers fo...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2007.02.009
更新日期：2007-06-01 00:00:00
abstract：:Root canal bacteria in teeth with apical periodontitis were enumerated after extraction and incubation. Canals in 36 teeth were sampled after: S1, incubation for 2 hours (group A), 2 days (group B), 4 days (group C), and 6 days (group D); S2, subsequent incubation for 1 week; S3, canal disinfection; and S4, final incu...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2008.08.038
更新日期：2008-12-01 00:00:00
abstract：INTRODUCTION:The purpose of this prospective, randomized, single-blind crossover study was to evaluate the anesthetic efficacy of a combination palatal and buccal infiltration of the maxillary first molar. MATERIALS AND METHODS:Using a crossover design, 40 subjects received two sets of maxillary first molar infiltrati...
journal_title：Journal of endodontics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.joen.2011.01.005
更新日期：2011-04-01 00:00:00
abstract：INTRODUCTION:This in vitro study compared cone-beam computed tomography (CBCT) exam with different voxel sizes with digital periapical radiography in the detection of vertical root fractures in teeth with and without intracanal metallic posts. METHODS:Eighteen single-rooted human teeth were endodontically treated, pre...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2013.08.031
更新日期：2013-12-01 00:00:00
abstract：INTRODUCTION:Culture-independent studies have revealed a broad spectrum of oral bacterial taxa that may be associated with disease. This study investigated the prevalence of three new candidate oral pathogens: Prevotella baroniae, Prevotella multisaccharivorax, and as-yet-uncultivated Bacteroidetes oral clone X083 in p...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2009.05.033
更新日期：2009-10-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to determine the extent of disinfection mediated by 2 concentrations of sodium hypochlorite for bacteria-laden dentin wall of a root canal. METHODS:A dual-species film, Enterococcus faecalis and Porphyromonas gingivalis, was cultivated on root canal dentin for 7 days. The canal w...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2013.09.045
更新日期：2014-06-01 00:00:00
abstract：:The aim of this laboratory based study was to determine the shaping ability of Lightspeed nickel-titanium rotary instruments in simulated root canals. A total of 40 canals with four different shapes in terms of angle and position of curve were prepared with Lightspeed instruments using the stepback technique recommend...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(97)80347-0
更新日期：1997-12-01 00:00:00
abstract：:With all the potential for endodontic success, the fact remains clinicians are confronted with posttreatment endodontic disease. When the elected treatment plan is endodontic nonsurgical retreatment, then the goal is to access the pulp chamber and remove materials from the root canal space and if present, address defi...
journal_title：Journal of endodontics
pub_type： 杂志文章,评审
doi：10.1097/01.don.0000145033.15701.2d
更新日期：2004-12-01 00:00:00
abstract：:One hundred single-rooted teeth were instrumented with Lightspeed, Profile .04 Taper Series 29, and NT McXIM instruments according to the recommendations of the manufacturers, and Flex-R files using the balanced force technique. Groups were comparable with respect to average curvature, canal length, and major and mino...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(98)80086-1
更新日期：1998-02-01 00:00:00
abstract：INTRODUCTION:A major complication after endodontic treatment is persistent pain on biting or chewing. Although unsuccessful endodontic treatment can account for such pain, pain to chewing and biting can also be a result of an unsupported or propagated crown fracture. Crown fractures that extend apically result in deter...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2014.06.021
更新日期：2015-01-01 00:00:00
abstract：:The effectiveness of endodontic antimicrobial treatment could be determined using sensitive molecular methods. The purpose of this study was to determine if antibiotics or endodontic reagents interfere with the ability of PCR to detect Enterococcus faecalis in vitro. Amoxicillin (25 mg/ml), clindamycin (15 mg/ml), tet...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/01.don.0000152899.54247.4e
更新日期：2005-07-01 00:00:00
abstract：INTRODUCTION:This study was conducted to evaluate and compare the fracture resistance of roots obturated with various contemporary canal-filling systems. METHODS:Fifty single-rooted extracted mandibular premolars were decoronated to obtain 13-mm root segments. Ten roots were left unprepared and unfilled (negative cont...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2011.08.008
更新日期：2011-11-01 00:00:00
abstract：INTRODUCTION:In this study, we investigated if apical periodontitis (AP) associated with diabetes influenced the levels of endogenous antioxidants, the total antioxidant capacity (TAC), and the oxidant parameter in the serum of Wistar rats. METHODS:Forty male rats were divided into 4 equal groups: normal rats (N), rat...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2017.05.014
更新日期：2017-10-01 00:00:00
abstract：INTRODUCTION:Currently, the success of periapical microsurgery is determined by the restoration of the lamina dura and the elimination of symptoms. However, inadequate site preservation may prevent later implant placement. Although not possible before, the advent of cone-beam computed tomographic imaging and computer-a...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2018.11.002
更新日期：2019-04-01 00:00:00
abstract：:The aims of this study were to compare Resilon (Resilon Research LLC, Madison, CT) in conjunction with either a bonding (Epiphany; Pentron Clinical Technologies, Wallingford, CT) or a nonbonding endodontic sealer (Pulp Canal Sealer; Kerr Corporation, Orange, CA) to EndoRez (Ultradent Products Inc, South Jordan, UT) an...
journal_title：Journal of endodontics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.joen.2007.02.018
更新日期：2007-07-01 00:00:00
