当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PEDIATRICS期刊下所有文献 > Risk factors for autism spectrum disorder in the Thai population.

Risk factors for autism spectrum disorder in the Thai population.

Abstract：

UNLABELLED:Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder commonly prevalent in children worldwide including Thailand. However, there are very few studies thus far addressing risk factors for ASD in Thai children. This case-control study aims to investigate whether various risk factors especially socioeconomic status, advanced parental age (age >35 years), perinatal factors, maternal autoimmune diseases, and family history of neuropsychiatric illnesses were associated with the risk of having an offspring with ASD. There were 235 children with ASD (age 8.44 ± 3.37 years) and 235 controls (age 8.39 ± 3.37 years) enrolled in this study. The risk of developing ASD in these children included advanced paternal age (adjusted odds ratio (AOR) = 3.49, 95 % confidence interval (CI) = 2.05-5.96), family history of neuropsychiatric illnesses particularly if such disorders came from the paternal side of the child's family (AOR = 2.87, 95 % CI = 1.29-6.39), and having unemployed mothers (AOR = 1.65, 95 % CI = 1.08-2.54). CONCLUSION:This study supports previous findings of Western countries where risk factors for ASD tend to occur in children whose fathers were of advanced paternal age and in the families with neuropsychiatric illnesses particularly if such disorders came from the paternal side of the child's family. WHAT IS KNOWN:• Family history of neuropsychiatric disorders and advanced paternal age are risk factors for ASD in the offspring previously identified in the studies in Europe and North America. What is New: • To our knowledge, this is the first study documenting risk factors for ASD in the Asian population. • Our study supports previous findings of Western countries where risk factors for ASD tend to occur in the families with neuropsychiatric illnesses particularly if such disorders came from the paternal side of the child's family.

journal_name

Eur J Pediatr

journal_title

European journal of pediatrics

authors

Khaiman C,Onnuam K,Photchanakaew S,Chonchaiya W,Suphapeetiporn K

doi

10.1007/s00431-015-2544-2

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

1365-72

issue

eissn

0340-6199

issn

1432-1076

pii

10.1007/s00431-015-2544-2

journal_volume

174

pub_type

杂志文章,多中心研究

在线工具

Risk factors for autism spectrum disorder in the Thai population.