Abstract:
:To assess prognostic factors for survival and describe Model for End-Stage liver disease (MELD) dynamics in human immunodeficiency virus+/hepatitis C virus+ (HIV+/HCV+) patients after an initial episode of hepatic decompensation.An HIV+/HCV+ cohort of patients experiencing an initial decompensation episode within the year preceding enrollment were followed prospectively. Clinical and biological data were collected every 3 months. Predictors for survival were identified using Kaplan-Meier curves and Cox models. A 2-slope-mixed linear model was used to estimate MELD score changes as a function of survival.Sixty seven patients were included in 32 centers between 2009 and 2012 (72% male; median age: 48 years [interquartile ratio (IQR):45-52], median follow-up: 22.4 months [range: 0.5-65.3]). Overall survival rates were 86%, 78%, and 59% at 6, 12, and 24 months, respectively. Under multivariate analysis, the MELD score at initial decompensation was predictive of survival, adjusted for age, type of decompensation, baseline CD4 counts, and further decompensation during follow-up as a time-dependent variable. The adjusted hazard ratio of death was 1.32 for a score 3 points higher (95% CI: [1.06-1.63], P = 0.012). MELD score kinetics within the 6 months after initial decompensation differed significantly between non-deceased and deceased patients, with a decreased (-0.49/month; P = 0.016), versus a flat (+0.06/month, P = 0.753) mean change in score.MELD is an effective tool to predict survival in HIV+/HCV+ patients with decompensated cirrhosis. A non-decreasing MELD score within 6 months following this initial decompensation episode may benefit from privileged access to liver transplantation in this poor prognosis population.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Gelu-Simeon M,Bayan T,Ostos M,Boufassa F,Teicher E,Steyaert JM,Bertucci I,Anty R,Pageaux GP,Meyer L,Duclos-Vallée JC,ANRS HC EP 25 PRETHEVIC study group.doi
10.1097/MD.0000000000001239subject
Has Abstractpub_date
2015-07-01 00:00:00pages
e1239issue
30eissn
0025-7974issn
1536-5964pii
00005792-201507050-00024journal_volume
94pub_type
杂志文章,多中心研究相关文献
MEDICINE文献大全abstract:BACKGROUND:Mild cognitive impairment (MCI) can be a stage of pre-dementia. Although the traditional Chinese exercise (TCE) has benefits associated with cognitive functions, the effects of the TCE on cognitive functions of older patients with MCI remain controversial. This study performs a meta-analysis to quantify the ...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000014581
更新日期:2019-02-01 00:00:00
abstract::In gastric cancer, HER2 protein overexpression is considered to be conducive to the higher proliferation activity of the tumor cells. Tumor formation is associated with angiogenesis in order to secure an abundant supply of oxygen and glucose to cancer cells. The aim of the study was to assess if HER2 overexpression is...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012854
更新日期:2018-10-01 00:00:00
abstract::In this study, we analyzed the difference of intestinal flora polymorphisms between Wilson's disease (WD) patients and healthy people by high-throughput sequencing technology, and explored the correlation between WD and intestinal flora polymorphism.A total of 22 cases of WD patients and 22 healthy persons as control ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011743
更新日期:2018-08-01 00:00:00
abstract::Qualitative and quantitative analyses of circulating cell-free DNA (cfDNA) are potential methods for the detection of hepatocellular carcinoma (HCC). Many studies have evaluated these approaches, but the results have been variable. This meta-analysis is the first to synthesize these published results and evaluate the ...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000000722
更新日期:2015-04-01 00:00:00
abstract:RATIONALE:Intravesical migrated intrauterine devices (IUDs) have been reported to cause bladder perforation, stone formation, or malignant transition. However, such extensive intravesical benign hyperplasia caused by an extravesical migrated IUD is firstly reported. PATIENT CONCERNS:A 38-year-old woman suffered from r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015671
更新日期:2019-05-01 00:00:00
abstract:RATIONALE:Degenerative spondylolisthesis is defined as forward slippage of a vertebra with respect to the underlying vertebra and is associated with the induction of lumbar canal stenosis. The use of anterior column support for degenerative lumbar conditions has been well documented. Direct lateral interbody fusion (DL...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014700
更新日期:2019-02-01 00:00:00
abstract::Congenital heart disease (CHD) is the most commonly diagnosed congenital disorder in newborns. The incidence and mortality of CHD vary worldwide. A detailed understanding of the global, regional, and national distribution of CHD is critical for CHD prevention.We collected the incidence and mortality data of CHD from t...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020593
更新日期:2020-06-05 00:00:00
abstract::Patients with head and neck cancer are treated through surgery, radiotherapy (RT), and chemotherapy (CT). Carotid artery damage and neurotoxicity were previously observed in these patients. This study estimated the dementia risk associated with different treatment modalities in a head and neck cancer population with l...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001983
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Bimatoprost has been reported to treat primary open-angle glaucoma (POAG) effectively. However, up-to-date, no systematic review has specifically addressed the efficacy and safety of bimatoprost for the treatment of POAG. Therefore, this study will propose to appraise the efficacy and safety of bimatoprost f...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000020356
更新日期:2020-06-05 00:00:00
abstract::Human serotonin receptor 4 (HTR4) encodes a 5-HT4 receptor involved in learning, memory, depression, anxiety, and feeding behavior. The aim of this study was to investigate the association between the deoxyribonucleic acid (DNA) methylation of HTR4 promoter and autism spectrum disorder (ASD), a disease characterized b...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018838
更新日期:2020-01-01 00:00:00
abstract:RATIONALE:Primary neuroendocrine tumors (NETs) of the retroperitoneum are extremely rare. The purpose of this case report is to highlight the unusual growth pattern and radiologic features of primary retroperitoneal NETs. PATIENT CONCERNS:A 46-year-old woman was found to have a retroperitoneal cystic and solid mass du...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000024054
更新日期:2021-01-15 00:00:00
abstract::Awake craniotomy is a unique technique utilized for mapping neuro and motor function during neurosurgical procedures close to eloquent brain tissue. Since active communication is required only during surgical manipulation of eloquent brain tissue and the patient is "sedated" during other parts of the procedure, differ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017473
更新日期:2019-10-01 00:00:00
abstract:RATIONALE:Intraspinal tophaceous gout is relatively rare condition presenting with major clinical manifestations, such as spinal cord or nerve roots compressions (radiculopathy). It is usually difficult to differentiate intraspinal tophaceous gout, lumbar disc herniation, stenosis of spinal canal, ossification of ligam...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020125
更新日期:2020-05-22 00:00:00
abstract::Instrumented spinal fusion has become one of the most common surgeries for patients with various spinal disorders. Only few studies have reported subsequent vertebral compression fractures (VCFs) after instrumented spinal fusion. The purpose of this study was to evaluate the risk of new VCFs in patients undergoing ins...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003455
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:It has been reported that the cluster of differentiation 14 (CD14) gene -159C/T variant may be associated with asthma risk. However, some studies yielded conflicting results. Therefore, a comprehensive meta-analysis was designed to assess the precise association. METHODS:A systematic search in PubMed, Embas...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000004959
更新日期:2016-09-01 00:00:00
abstract::Since the progression of cirrhosis is accelerated each time a complication recurs, the management and treatment of the complication is critical in enhancement of the quality of life and expectation of life in patients. The use of model for end-stage liver disease with incorporation of serum-sodium (MELD-Na) with physi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017862
更新日期:2019-11-01 00:00:00
abstract::Brain metastases deriving from esophageal cancer are very rare with scarce data available concerning these patients' outcome. We, therefore, evaluated outcome after surgical resection followed by radiotherapy of brain metastasis from esophageal cancer.A retrospective analysis was conducted on consecutive patients unde...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000016653
更新日期:2019-08-01 00:00:00
abstract::High prevalence of obstructive sleep apnea (OSA) has increased the demands for more convenient and accessible diagnostic devices other than standard in-lab polysomnography (PSG). Despite the increasing utility of photoplethysmograph (PPG), it remains understudied in underserved populations. This study aimed to evaluat...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006755
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Cardiopulmonary bypass (CPB) is necessary for most cardiac surgery, which may lead to postoperative lung injury. The objective of this paper is to systematically evaluate whether ventilation during CPB would benefit patients undergoing cardiac surgery. METHODS:We searched randomized controlled trials (RCTs)...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000006454
更新日期:2017-03-01 00:00:00
abstract:INTRODUCTION:Despite the benefits, cardiovascular rehabilitation programs (CRPs) have been related to the appearance of signals and symptoms. Risk stratification protocols are commonly used to identify risks during the physical exercise; however, studies that investigate their efficacy to previse signals and symptoms a...
journal_title:Medicine
pub_type: 临床试验,杂志文章
doi:10.1097/MD.0000000000015700
更新日期:2019-06-01 00:00:00
abstract::Acute cellular rejection after liver transplantation (LT) can be treated with steroid pulse therapy, but there is no ideal treatment for steroid-resistant acute rejection (SRAR). We aimed to determine the feasibility and potential complications of rabbit anti-thymocyte globulin (rATG) application to treat SRAR in live...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003711
更新日期:2016-06-01 00:00:00
abstract:INTRODUCTION:The current evidence confirms the effectiveness and safety of several drug interventions in the treatment of acute flares of gout, however, the most preferred drugs are still unclear. We, therefore, seek to conduct a network meta-analysis that can systematically compare non-steroidal anti-inflammatory drug...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019668
更新日期:2020-04-01 00:00:00
abstract::Incidental gastric subepithelial tumor (SET) is frequently found during endoscopy. Although endoscopic ultrasonography (EUS) can provide useful information, its diagnostic accuracy varies. Most of the potentially malignant tumors observed on EUS are hypoechoic lesions. Therefore, we aimed to investigate the diagnostic...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005246
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The prognostic significance of CD44 variant-9 (CD44v9) expression in human cancers has been investigated in several studies, however, definite conclusion has not be reached. The aim of this systematic review and meta-analysis was to evaluate the prognostic significance of CD44v9 expression in various cancers...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000020428
更新日期:2020-07-24 00:00:00
abstract:RATIONALE:Rectal neuroendocrine tumor (NET) is a relatively rare tumor. Well-differentiated NETs (G1 and G2) rarely display distant metastasis at initial diagnosis. Currently, treatment for the primary lesions of rectal NETs with liver metastasis remains controversial. The liver metastasis was resected in local hospita...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009153
更新日期:2017-12-01 00:00:00
abstract::To evaluate the predictive and prognostic significance of the prognostic nutritional index (PNI) in a large cohort of gastric cancer patients who underwent gastrectomy.Assessing a patient's immune and nutritional status, PNI has been reported as a predictive marker for surgical outcomes in various types of cancer.We r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003539
更新日期:2016-05-01 00:00:00
abstract:RATIONALE:Patients who undergo hilar cholangiocarcinoma (HCAC) resection with concomitant hepatectomy have a high risk of postoperative morbidity and mortality due to surgical trauma to the hepatic and biliary vasculature. PATIENT CONCERNS:A 58-year-old Chinese man with yellowing skin and sclera, abdominal distension,...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008083
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To find out whether the intramedullary fixations are superior to the extramedullary fixations in treating unstable femoral intertrochanteric fractures (UFIFs). METHODS:The meta-analysis of randomized controlled trials (RCTs) was conducted by searching the PubMed, Cochrane Library, and Embase databases to evalu...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000017010
更新日期:2019-09-01 00:00:00
abstract::Acute renal failure (ARF) is a common complication in infants who undergo cardiac surgery in the intensive care unit. We report on a modified drainage catheter used in peritoneal dialysis (PD) for the treatment of ARF associated with cardiac surgery in infants. Thirty-nine infants with congenital heart disease undergo...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000077
更新日期:2014-09-01 00:00:00
abstract::Administration of intravenous vancomycin has been associated with the development of linear IgA bullous disease (LABD). In contrast to the idiopathic variant, vancomycin-induced LABD (VILABD) appears to be more transient and to be associated with lower morbidity. The characteristics of this entity remain undefined. Ou...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-199901000-00001
更新日期:1999-01-01 00:00:00