Abstract：
OBJECTIVE:The incidence of nonsteroidal anti-inflammatory drugs (NSAIDs)-induced enteropathy is currently increasing. However, the predictors of small bowel bleeding (SBB) associated with NSAIDs are unknown. This study aimed to assess the risk factors of SBB in chronic NSAIDs users. METHODS:We retrospectively compared the medical records of 147 patients receiving NSAIDs in a tertiary-care setting (31 with SBB and 116 without previous bleeding events) and analyzed the predictors of SBB. RESULTS:In total, 31 patients underwent video capsule endoscopy to detect SBB, 74.2% of whom showed the evidence of SBB. Non-invasive treatment was performed in 90.3% of the patients. Multivariate logistic regression analysis revealed that the presence of coronary artery disease [adjusted odds ratio (aOR) 12.43, 95% confidence interval (CI) 1.19-130.34, P = 0.04], use of thienopyridine (aOR 16.93, 95% CI 3.78-75.72, P < 0.001) and prior use of rebamipide (aOR 0.31, 95% CI 0.12-0.82, P = 0.02) were independently associated with SBB in NSAIDs users. CONCLUSIONS:Coronary artery disease and co-use of thienopyridine were associated with SBB in NSAIDs users. The patients with coronary artery disease co-using thienopyridine need to be monitored for the occurrence of SBB when they were prescribed with NSAIDs.
journal_name
J Dig Disjournal_title
Journal of digestive diseasesauthors
Cho KM,Park SY,Chung JO,Jun CH,Kim TJ,Son DJ,Kim BS,Park CH,Kim HS,Choi SK,Rew JSdoi
10.1111/1751-2980.12269subject
Has Abstractpub_date
2015-09-01 00:00:00pages
499-504issue
9eissn
1751-2972issn
1751-2980journal_volume
16pub_type
杂志文章abstract：OBJECTIVE:To carry out a comprehensive study on gastrointestinal symptoms, motility and autonomic neuropathy in chronic alcoholics before and one year after abstinence. METHODS:Dyspeptic symptoms (questionnaires), fasting and postprandial gallbladder and gastric motility (ultrasonography), oro-cecal transit time (lact...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
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abstract：OBJECTIVE:To investigate retrospectively the efficacy of steroids in patients with acute-on-chronic liver failure (ACLF) precipitated by hepatitis B. METHODS:Patients with ACLF precipitated by hepatitis B were included and categorized according to treatment modalities (steroid vs. control). Survival and clinical chara...
journal_title：Journal of digestive diseases
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doi：10.1111/1751-2980.12691
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:To evaluate whether patients with malignant biliary obstruction (MBO) benefit from balloon dilation before the placement of a self-expanding metal stent (SEMS) for palliative biliary drainage. METHODS:Consecutive patients who underwent endoscopic retrograde cholangiopancreatography with SEMS placement for pa...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12798
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:Non-steroidal anti-inflammatory drugs (NSAID) induce gastroduodenal mucosal injury and are metabolized by cytochrome P450 2C9 (CYP2C9). It is postulated that CYP2C9 genotype is associated with NSAID-induced gastropathy. This study aims to determine whether individuals with a CYP2C9 allele mutation are suscept...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2008.00326.x
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:The microenvironment of tumors constitutes a unique niche that promotes cancer metastasis and resistance. Two remarkable characteristics of this microenvironment are hypoxia and inflammation. Interleukin-1α (IL-1α), an important inflammatory factor, is frequently upregulated in a variety of cancers. This stud...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12496
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the role of endoscopic drainage and endoscopic necrosectomy in the management of symptomatic pancreatic fluid collection. METHODS:The clinical data of patients with symptomatic pancreatic fluid collection referred for endoscopic drainage were captured prospectively and analyzed. Pancreatic duct d...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2009.00388.x
更新日期：2009-08-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2009.00412.x
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to analyze the incidence and risk factors of de novo hepatitis B virus (HBV) infection from hepatitis B core antibody (anti-HBc)-positive donors in pediatric living donor liver transplantation (LDLT). METHODS:We retrospectively analyzed 46 recipients without pre-liver transplantatio...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12066
更新日期：2013-08-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章,评审
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更新日期：2014-01-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2012.00616.x
更新日期：2012-09-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章,评审
doi：10.1111/1751-2980.12849
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of the non-cytotoxic drug (cyclooxygenase-2 (COX-2) inhibitor and octreotide) on growth of the multidrug-resistant human gastric carcinoma cell line SGC-7901/ADR. METHODS:The effects of non-cytotoxic drug on the growth of SGC-7901 and SGC-7901/ADR cells were evaluated by (3)H-thymi...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2009.00370.x
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:Systematic reports on acute upper gastrointestinal bleeding in children/adolescents are scanty. The aim of this study is to analyze its presentation, pathology and outcome in Hong Kong. METHODS:A retrospective review of the hospital database for admissions up to the age of 18 years with signs of acute upper ...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2008.00346.x
更新日期：2008-11-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12342
更新日期：2016-04-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1443-9573.2007.00321.x
更新日期：2008-02-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章,多中心研究
doi：10.1111/1751-2980.12106
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVE:Data on the association between the antioxidant capacity of a diet and the risk of ulcerative colitis (UC) are scarce. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of UC in Iranian adults. METHODS:In this case-control study, patients w...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12823
更新日期：2019-12-01 00:00:00
abstract：:Acute non-variceal upper gastrointestinal bleeding (ANVUGIB) is one of the most common medical emergencies in China and worldwide. In 2009, we published the "Guidelines for the diagnosis and treatment of acute non-variceal upper gastrointestinal bleeding" for the patients in China; however, during the past years numer...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,实务指引
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更新日期：2016-02-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12250
更新日期：2015-08-01 00:00:00
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journal_title：Journal of digestive diseases
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doi：10.1111/1751-2980.12082
更新日期：2013-10-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章,评审
doi：10.1111/1751-2980.12305
更新日期：2016-01-01 00:00:00
abstract：:The development of alcoholic liver disease (ALD) is a complex process involving both the parenchymal and non-parenchymal cells in the liver. The impact of ethanol on hepatocytes can be characterized as a condition of organelle stress with multifactorial changes in hepatocellular function accumulating during ethanol ex...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,评审
doi：10.1111/j.1751-2980.2010.00468.x
更新日期：2011-02-01 00:00:00
abstract：:Cytomegalovirus, regarded as a trigger of several autoimmune diseases, is an opportunistic pathogen. Patients with ulcerative colitis (UC) undergoing steroid treatment are susceptible to this infection. In the presence of cytomegalovirus, inflammation becomes more complex. Patients with active UC who are infected with...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,评审
doi：10.1111/1751-2980.12037
更新日期：2013-04-01 00:00:00
abstract：:The incidence of early esophageal adenocarcinoma has been increasing significantly in recent decades. Prognosis depends greatly on the choice of treatment. Early cancers can be treated by endoscopic resection, whereas advanced carcinomas have to be sent for surgery. Esophageal resection is associated with high periope...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,评审
doi：10.1111/1751-2980.12264
更新日期：2015-07-01 00:00:00
abstract：OBJECTIVE:We aimed to identify the features of microRNA (miRNA) at different fibrotic stages in patients with hepatitis B virus (HBV)-related liver fibrosis. METHODS:Liver tissues were collected from 40 chronic hepatitis B (CHB) patients at fibrotic stages S0-4. Microarrays of miRNAs and genomic informatics analysis w...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12452
更新日期：2017-02-01 00:00:00
abstract：:The incidence and prevalence of inflammatory bowel disease (IBD) show considerable variation over time and across geographical regions. The first studies on the epidemiology of IBD were mainly from traditionally high-incidence areas, such as North America, and northern and western Europe. In the last two decades, more...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,评审
doi：10.1111/1751-2980.12449
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:The monocyte chemoattractant protein-1 (MCP-1) -A2518G gene polymorphism has been found to be involved in the susceptibility to inflammatory bowel disease (IBD); however, the results of existing studies are controversial. The aim of this meta-analysis was to assess the relationship between the MCP-1 -A2518G p...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,meta分析,评审
doi：10.1111/1751-2980.12232
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:Methotrexate (MTX) can be used as an alternative for patients with Crohn's disease (CD) who are intolerant of thiopurine. This retrospective study aimed to provide some clues about MTX treatment in Chinese patients with CD. METHODS:Medical records of 27 adult patients with CD who were treated with MTX betwee...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12694
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:Ursodeoxycholic acid (UDCA) is widely used to treat chronic liver diseases, and its cytoprotective effect on normal hepatocytes has been shown. This study aimed to investigate the apoptotic effects of UDCA on hepatocellular carcinoma (HCC) cells and the underlying molecular events in vitro. METHODS:HCC cells...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12191
更新日期：2014-12-01 00:00:00
