Abstract:
:Epigenetic regulatory mechanisms play key roles in cardiac development, differentiation, homeostasis, response to stress and injury, and disease. Human heart failure (HF) epigenetic regulatory mechanisms have not been deciphered to date. This 2-part review distills the rapidly evolving research focused on human HF epigenetic regulatory mechanisms. Part I, which was published in the September/October issue, focused on epigenetic regulatory mechanisms involving RNA, specifically the role of short, intermediate, and long noncoding RNAs (lncRNAs) and endogenous competing RNA regulatory networks. Part II, now in the November/December issue, focuses on the epigenetic regulatory mechanisms involving DNA, including DNA methylation, histone modifications, and chromatin conformational changes. Part II concludes with 2 examples of well-studied integrated epigenetic regulatory mechanisms: the structural and functional roles of the Mediator complex in regulating transcription and the epigenetic networked "cross-talk" regulating atrial natriuretic peptide and brain natriuretic peptide promoter activation.
journal_name
Cardiol Revjournal_title
Cardiology in reviewauthors
DiSalvo TGdoi
10.1097/CRD.0000000000000074subject
Has Abstractpub_date
2015-11-01 00:00:00pages
269-81issue
6eissn
1061-5377issn
1538-4683journal_volume
23pub_type
杂志文章,评审abstract::Saphenous vein graft (SVG) disease after coronary artery bypass grafting (CABG) occurs in three phases: thrombosis, intimal hyperplasia, and atherosclerosis. Within the first month, thrombosis plays a major role. From month 1 to month 12, intimal hyperplasia occurs. Beyond 12 months, atherosclerosis becomes the primar...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e3182736190
更新日期:2013-03-01 00:00:00
abstract::In this article, we critically evaluate the evidence relating to the effects of the Mediterranean diet (MD) on the risk of cardiovascular disease (CVD). Strong evidence indicating that the MD prevents CVD has come from prospective cohort studies. However, there is only weak supporting evidence from randomized controll...
journal_title:Cardiology in review
pub_type: 杂志文章,meta分析,评审
doi:10.1097/CRD.0000000000000222
更新日期:2019-05-01 00:00:00
abstract::The obesity epidemic has reached unprecedented proportions in Western society. Evidence continues to accumulate that obesity is associated with significant morbidity and mortality and in particular that it is an independent risk factor for cardiovascular disease (CVD). The association of obesity with CVD and its risk ...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200107000-00005
更新日期:2001-07-01 00:00:00
abstract::Intravascular ultrasound imaging is a relatively new imaging modality that uses miniaturized ultrasound transducers, which are mounted on catheter tips and introduced into the vessel lumen to provide cross-sectional images of the vascular structure in real time. It has gained popularity rapidly among interventional ca...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-199909000-00014
更新日期:1999-09-01 00:00:00
abstract::Arsenic is a ubiquitously dispersed metalloid that has been implicated as the cause of various adverse health effects. Human exposure to arsenic primarily occurs through contaminated drinking water and dietary intake of rice and grains, posing a great public health risk to millions of people worldwide. High levels of ...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/CRD.0000000000000357
更新日期:2020-09-15 00:00:00
abstract::The field of durable left ventricular assist devices has advanced dramatically since its introduction into the clinical realm. From the first-generation pulsatile HeartMate XVE device to the second-generation continuous axial flow HeartMate-2 to the current third-generation centrifugal flow devices, the left ventricul...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000268
更新日期:2019-11-01 00:00:00
abstract::Intensive glycemic control significantly increases the risk of hypoglycemia in patients with diabetes mellitus. Recent data have shown that hypoglycemia may also be a marker of cardiovascular disease in these patients. We performed a systemic review and a meta-analysis to evaluate the relationship between severe hypog...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/CRD.0000000000000276
更新日期:2020-09-01 00:00:00
abstract::Two-dimensional speckle tracking echocardiography represents a novel, simple, and reproducible technique for the estimation of left ventricular myocardial deformation (strain) and the evaluation of left ventricular twist mechanics. During the last few years, its clinical and prognostic implications in cardiomyopathies...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000172
更新日期:2018-05-01 00:00:00
abstract::Computed tomography is an established tool in the assessment of cardiac anatomy and function. As demonstrated by single photon emission computed tomography, positron emission tomography, and magnetic resonance, the noninvasive evaluation of coronary hemodynamics is an important step in guiding clinical management. Nev...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/CRD.0000000000000242
更新日期:2019-07-01 00:00:00
abstract::We report a case of spontaneous coronary artery rupture associated with amphetamine abuse in a 31-year-old woman. The patient presented to the emergency department with sudden onset of central chest pain and a normal electrocardiogram. Cardiac enzymes were consistent with acute myocardial infarction. Drug screening wa...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/01.crd.0000132372.38506.45
更新日期:2004-09-01 00:00:00
abstract::Established coronary artery disease has a prevalence of 7% in adult Americans, accounting for 16 million people. As morbidity and mortality rates have risen, research efforts to identify the pathophysiologic mechanisms of systolic dysfunction have risen in parallel. The current goal is to develop new therapeutic strat...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000024
更新日期:2014-09-01 00:00:00
abstract::Spontaneous nontraumatic intracerebral hemorrhage is associated with high morbidity and mortality. Given the risk of rapid neurological deterioration, early identification with rapid neuroimaging is vital. Predictors of outcome, such as spot sign and intracerebral hemorrhage score, can help guide management goals. Man...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/CRD.0000000000000332
更新日期:2021-01-01 00:00:00
abstract::The physiologic effect of the sauna in human beings has been studied extensively, but only recently have there been studies to suggest sauna can be an effective therapeutic modality for patients with cardiovascular disease, especially for those with congestive heart failure. The data reported to date have been promisi...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/01.crd.0000124844.56479.05
更新日期:2004-11-01 00:00:00
abstract::The differentiation of left ventricular pseudoaneurysm from true aneurysm is sometimes difficult. Given the propensity for pseudoaneurysms to rupture leading to cardiac tamponade, shock, and death, compared with a more benign natural history for true aneurysms, accurate diagnosis of these conditions is clinically impo...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/01.crd.0000233756.66532.45
更新日期:2006-11-01 00:00:00
abstract::Reverse redistribution is a well-known pattern found when performing thallium myocardial scintigraphy, and it has been implicated as an indicator of myocardial ischemia. Much more rarely, when using technetium compounds, which do not redistribute, a similar pattern is noted after the second injection of the radiotrace...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/01.crd.0000115927.76990.25
更新日期:2004-05-01 00:00:00
abstract::Sudden death (SD) is the most dramatic event in hypertrophic cardiomyopathy (HCM), often representing the first clinical manifestation of the disease, and the first concern of the clinicians who take care of such patients. HCM is now recognized as the primary cause of SD in young persons (<35 years of age), including ...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000017
更新日期:2014-09-01 00:00:00
abstract::This article provides a brief overview of several recently developed, emerging technologies and discusses their potential uses on clinical grounds. These new technologies include three-dimensional imaging, objective automated evaluation of ventricular function with acoustic quantification, assessment of regional ventr...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200105000-00008
更新日期:2001-05-01 00:00:00
abstract::Atherosclerosis develops and rapidly progresses in saphenous veins grafts after coronary bypass surgery. In contrast to native coronary artery, percutaneous revascularization does not impede the progression of saphenous vein atherosclerosis and saphenous vein graft failure commonly ensues. The protracted patency of ar...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/CRD.0000000000000277
更新日期:2020-09-01 00:00:00
abstract::Cardiovascular disease is the leading cause of death in the United States, accounting for approximately 60% of total mortality in 2002. There is evidence that race and ethnicity is a risk factor for atherothrombotic events. Blacks have a greater risk of complications from coronary heart disease and unstable angina, wi...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e31815685fa
更新日期:2008-03-01 00:00:00
abstract::The increased life expectancy of women living in industrialized countries is associated with an increase in diseases dependent or facilitated by a state of estrogen deficiency, such as cardiovascular and cerebrovascular diseases. Several studies have shown that estrogen replacement therapy reduces the occurrence of co...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200201000-00010
更新日期:2002-01-01 00:00:00
abstract::The complex mechanism of platelet activation creates an optimal target for pharmacological treatment in patients with acute coronary syndromes. Current antiplatelet medications that are used in addition to aspirin include the thienopyridines, clopidogrel and prasugrel, but there are several limitations to the use of t...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e3182099d86
更新日期:2011-03-01 00:00:00
abstract::Atrial fibrillation (AF) is a common cardiac arrhythmia with significant morbidity and public health cost. Because of limitations of efficacy and safety of conventional antiarrhythmic agents, alternative therapies for AF are needed. The potential antiarrhythmic properties of lipid-altering therapy, including the 3-hyd...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e318177271d
更新日期:2008-07-01 00:00:00
abstract::Cardiovascular disease is the leading cause of death in women in most developed countries of the world. Even though cardiovascular deaths of men in the United States have been declining, until recently the number of cardiovascular deaths in US women was on the rise, with 1 in 3 women dying from heart disease. Over the...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e31815cb185
更新日期:2008-01-01 00:00:00
abstract::The ever-increasing complexity of medical device therapy and installation of public electronic security systems demands vigilance in discerning interactions that may be harmful to patients during typical activities of daily living. Premature pacemaker stimulation, isolated skipped beats, or reversion to backup asynchr...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200101000-00004
更新日期:2001-01-01 00:00:00
abstract::As direct oral anticoagulants (DOACs) have demonstrated favorable efficacy and safety outcomes compared with vitamin K antagonists for the treatment and prevention of venous thromboembolism and the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, their role in the management...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000188
更新日期:2018-09-01 00:00:00
abstract::Evacetrapib is a cholesteryl ester transfer protein (CETP) inhibitor that has been recently studied as a cholesterol modifying agent to reduce cardiovascular risk and mortality in high risk cardiovascular disease patients. Evacetrapib acts to decrease lipid exchange through CETP inhibition. CETP acts to transfer chole...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000137
更新日期:2017-03-01 00:00:00
abstract::The introduction of new medicines to treat pulmonary vascular disease has renewed interest in the management of children with idiopathic pulmonary arterial hypertension. We now have a practical classification of pulmonary hypertension, improved diagnostic techniques, and internationally recognized diagnostic and manag...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e3181ce03df
更新日期:2010-03-01 00:00:00
abstract::Acute pericarditis (AP) is basically a clinical diagnosis. Although specific electrocardiographic (ECG) manifestations may indeed point to its diagnosis, sole reliance on such findings in isolation of the clinical setting, however, is often the common pitfall that could lead to a misguided diagnosis. We briefly review...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/01.crd.0000210645.89717.34
更新日期:2007-01-01 00:00:00
abstract::Primary pulmonary hypertension and cor pulmonale represent forms of precapillary pulmonary hypertension due to intrinsic lung disease. In the case of primary pulmonary hypertension, this is due to disease of the pulmonary vasculature while cor pulmonale is related to diseases of the pulmonary vasculature, airways, or ...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200209000-00003
更新日期:2002-09-01 00:00:00
abstract::Vitamin K antagonists (VKAs) such as warfarin have traditionally been the major therapeutic option for anticoagulation in clinical practice. VKAs are effective and extensively recommended for the prevention of venous and arterial thromboembolism in cardiovascular disease. Despite its effectiveness, warfarin is limited...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e3182503e2d
更新日期:2012-09-01 00:00:00