Biochemical and Genetic Analysis of Seven Korean Individuals With Suspected Metachromatic Leukodystrophy.

abstract：:There have been a number of studies about correlations between HLA genotypes in various ethnic groups and occurrence of various cutaneous adverse drug reactions, ranging in intensity from mild to severe, caused by antiepileptic drugs (AEDs). This is the first report analyzing the HLA genotypes of 9 Korean patients wit...

journal_title：Annals of laboratory medicine

authors： Song JS,Kang ES,Joo EY,Hong SB,Seo DW,Lee SY

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The storage temperature and time of blood gas samples collected in syringes constitute preanalytical variables that could affect blood gas or lactate concentration measurement results. We analyzed the effect of storage temperature and time delay on arterial or venous blood gas stability related to pH, partia...

journal_title：Annals of laboratory medicine

authors： Arbiol-Roca A,Imperiali CE,Dot-Bach D,Valero-Politi J,Dastis-Arias M

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:The gold standard for antinuclear antibody (ANA) screening is the indirect immunofluorescence (IIF) assay with human epithelial cells (HEp-2). However, a number of substantial disadvantages of manual IIF assays have highlighted the need for the automation and standardization of fluorescent ANA (FANA) testing...

journal_title：Annals of laboratory medicine

authors： Yoo IY,Oh JW,Cha HS,Koh EM,Kang ES

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The impact of HLA and KIR ligand mismatching on the outcome of hematopoietic stem cell transplantation (HSCT) remains unclear. Previous reports have identified considerable ethnic differences in the impact of HLA and KIR ligand mismatches, as well as KIR ligand status, on HSCT; however, to date, no data has ...

journal_title：Annals of laboratory medicine

authors： Park H,Rho EY,In JW,Kim I,Yoon SS,Park S,Shin S,Park KU,Song EY

更新日期：2015-01-01 00:00:00

abstract：:As various linezolid resistance mechanisms have been identified in methicillin-resistant Staphylococcus aureus (MRSA), we investigated the molecular characteristics of MRSA with elevated linezolid minimum inhibitory concentrations (MICs), using the VITEK 2 system (bioMérieux, Marcy-l'Étoile, France). Twenty-seven MRSA...

journal_title：Annals of laboratory medicine

authors： Yoo IY,Kang OK,Shim HJ,Huh HJ,Lee NY

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Delamanid, bedaquiline, and linezolid have recently been approved for the treatment of multidrug- and extensively drug-resistant (MDR and XDR, respectively) tuberculosis (TB). To use these drugs effectively, drug susceptibility tests, including rapid molecular techniques, are required for accurate diagnosis ...

journal_title：Annals of laboratory medicine

authors： Yang JS,Kim KJ,Choi H,Lee SH

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:High-sensitivity cardiac troponin I (hs-cTnI) and the soluble isoform of suppression of tumorigenicity 2 (sST2) are useful prognostic biomarkers in acute coronary syndrome (ACS). The aim of this study was to test the short term prognostic value of sST2 compared with hs-cTnI in patients with chest pain. METH...

journal_title：Annals of laboratory medicine

authors： Marino R,Magrini L,Orsini F,Russo V,Cardelli P,Salerno G,Hur M,Di Somma S,GREAT NETWORK.

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:This study was aimed to investigate the genetic diversity and antibiotic resistance profile of the nosocomial infection agent Acinetobacter baumannii from a medical intensive care unit (ICU) in a teaching hospital in Suzhou, China. METHODS:The genetic relationship among A. baumannii isolates in an ICU was i...

journal_title：Annals of laboratory medicine

authors： Zhong Q,Xu W,Wu Y,Xu H

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Macrophage colony-stimulating factor (M-CSF), matrix metalloproteinase-9 (MMP-9), and its specific tissue inhibitor - tissue inhibitor of metalloproteinases-1 (TIMP-1) may play an important role in the pathogenesis and spread of cancer. We investigated the plasma levels of M-CSF, MMP-9, and TIMP-1 in compari...

journal_title：Annals of laboratory medicine

authors： Ławicki S,Głażewska EK,Sobolewska M,Będkowska GE,Szmitkowski M

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Clopidogrel is one of the most commonly used anti-platelet agents in cardiovascular diseases. We analyzed the relationship between the platelet function analyzer (PFA)-200 P2Y (INNOVANCE PFA-200 System, Siemens Healthcare, Germany) results and occurrence of major adverse cardiac events (MACEs) in Korean pati...

journal_title：Annals of laboratory medicine

authors： Lim HH,Li S,An GD,Woo KS,Kim KH,Kim JM,Kim MH,Han JY

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:During the 2015 outbreak of Middle East Respiratory Syndrome coronavirus (MERS-CoV), six different commercial MERS-CoV RNA detection kits based on real-time reverse-transcription polymerase chain reaction (rRT-PCR) were available in Korea. We performed analytical and clinical validations of these kits. METH...

journal_title：Annals of laboratory medicine

authors： Kim MN,Ko YJ,Seong MW,Kim JS,Shin BM,Sung H

更新日期：2016-09-01 00:00:00

abstract：:Procalcitonin (PCT) is used as a biomarker for the diagnosis of sepsis, severe sepsis and septic shock. At the same time, PCT has also been used to guide antibiotic therapy. This review outlines the main indications for PCT measurement and points out possible pitfalls. The classic indications for PCT measurement are: ...

journal_title：Annals of laboratory medicine

authors： Meisner M

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Although single antigen bead assays (SAB) are approved qualitative tests, the median fluorescence intensity (MFI) values obtained from SAB are frequently used in combination with quantitative significances for diagnostic purposes. To gauge the reproducibility of SAB results, we assessed the interlaboratory v...

journal_title：Annals of laboratory medicine

authors： Oh EJ,Park H,Park KU,Kang ES,Kim HS,Song EY

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Narcolepsy is a neurologic disorder characterized by excessive daytime sleepiness, symptoms of abnormal rapid eye movement (REM) sleep, and a strong association with HLA-DRB1*1501, -DQA1*0102, and -DQB1*0602. Here, we investigated the clinico-physical characteristics of Korean patients with narcolepsy, their...

journal_title：Annals of laboratory medicine

authors： Woo HI,Joo EY,Hong SB,Lee KW,Kang ES

更新日期：2012-01-01 00:00:00

abstract：:Myocardial infarction (MI) is the leading cause of death in the developed world. Biomarkers have an essential role in diagnosis, risk stratification, guiding management and clinical decision making in the setting of patients presenting with signs and symptoms of MI. Cardiac troponin (cTn) rose to prominence during the...

journal_title：Annals of laboratory medicine

authors： Christenson E,Christenson RH

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:To rapidly obtain outpatient results, we use plasma separation tubes (PST) for chemistry analysis. If lactate dehydrogenase measurement is required, serum separation tubes (SST) are used. There has been no evaluation of hemolysis with these tubes. We compared the hemolytic index (HI) obtained by using PST an...

journal_title：Annals of laboratory medicine

authors： Ko DH,Won D,Jeong TD,Lee W,Chun S,Min WK

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Although the incidence of tuberculosis (TB) is decreasing, cases of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB continue to increase. As conventional phenotype drug susceptibility testing (pDST) takes six to eight weeks, molecular assays are widely used to determine drug resistance. ...

journal_title：Annals of laboratory medicine

authors： Chang Y,Kim S,Kim Y,Ei PW,Hwang D,Lee J,Chang CL,Lee H

更新日期：2020-03-01 00:00:00

abstract：:The platelet-to-lymphocyte ratio (PLR) has emerged as an informative marker revealing shifts in platelet and lymphocyte counts due to acute inflammatory and prothrombotic states. PLR has been extensively examined in neoplastic diseases accompanied by immune suppression and thrombosis, which can be predicted by combine...

journal_title：Annals of laboratory medicine

authors： Gasparyan AY,Ayvazyan L,Mukanova U,Yessirkepov M,Kitas GD

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Differentiation of atypical pathogens is important for community-acquired pneumonia (CAP). In this study, we compared sputum and nasopharyngeal swabs (NPS) for use in detection of Mycoplasma pneumoniae (MP), Chlamydophila pneumoniae (CP), and Legionella pneumophila (LP), using Seeplex PneumoBacter ACE Detect...

journal_title：Annals of laboratory medicine

authors： Cho MC,Kim H,An D,Lee M,Noh SA,Kim MN,Chong YP,Woo JH

更新日期：2012-03-01 00:00:00

abstract：:Angiogenesis is important for the proliferation and survival of multiple myeloma (MM) cells. Bone marrow (BM) microvessel density (MVD) is a useful marker of angiogenesis and an increase in MVD can be used as a marker of poor prognosis in MM patients. We developed an automated image analyzer to assess MVD from images ...

journal_title：Annals of laboratory medicine

authors： Chung Y,Shin S,Shim H,Sohn JY,Lee DE,Lee H,Eom HS,Kim KG,Kong SY

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:The level of Galectin-3 (Gal-3) protein purportedly reflects an ongoing cardiac fibrotic process and has been associated with ventricular remodeling, which is instrumental in the development of heart failure with preserved ejection fraction (HFpEF) syndrome. The aim of this study was to investigate the poten...

journal_title：Annals of laboratory medicine

authors： Ansari U,Behnes M,Hoffmann J,Natale M,Fastner C,El-Battrawy I,Rusnak J,Kim SH,Lang S,Hoffmann U,Bertsch T,Borggrefe M,Akin I

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Duffy (FY) blood group genotyping is important in transfusion medicine because Duffy alloantibodies are associated with delayed hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. In this study, FY allele frequencies in Thai blood donors were determined by in-house PCR with sequen...

journal_title：Annals of laboratory medicine

authors： Nathalang O,Intharanut K,Siriphanthong K,Nathalang S,Kupatawintu P

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The clindamycin-resistant erythromycin-susceptible (CRES) phenotype is rare in Streptococcus agalactiae (group B streptococci). We aimed to determine the molecular characteristics of CRES S. agalactiae using whole genome sequencing (WGS). METHODS:Sixty-six S. agalactiae isolates obtained from blood (N=26), ...

journal_title：Annals of laboratory medicine

authors： Takahashi T,Maeda T,Lee S,Lee DH,Kim S

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:With the advent of sodium glucose co-transporter 2 inhibitors to control glucose and treat diabetes, laboratory data aided by either timed or spot glucose levels in the urine could be used as an alternative marker of drug response. The aim of this study was to assess the agreement between overnight urinary g...

journal_title：Annals of laboratory medicine

authors： Kim SR,Lee YH,Lee SG,Lee SH,Kang ES,Cha BS,Lee HC,Kim JH,Lee BW

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Mutations in calreticulin (CALR) have been reported to be key markers in the molecular diagnosis of myeloid proliferative neoplasms. In most previous reports, CALR mutations were analyzed by using Sanger sequencing. Here, we report a new, rapid, and convenient system for screening CALR mutations without sequ...

journal_title：Annals of laboratory medicine

authors： Jeong JH,Lee HT,Seo JY,Seo YH,Kim KH,Kim MJ,Lee JH,Park J,Hong JS,Park PW,Ahn JY

更新日期：2016-07-01 00:00:00

abstract：:The 2016 WHO diagnostic criteria for chronic myelomonocytic leukemia (CMML) require both absolute and relative monocytosis (≥1×10⁹/L and ≥10% of white blood cell counts) in peripheral blood. Moreover, myeloproliferative neoplasm (MPN) features in bone marrow and/or MPN-associated mutations tend to support MPN with mon...

journal_title：Annals of laboratory medicine

authors： Moon Y,Kim MH,Kim HR,Ahn JY,Huh J,Huh JY,Han JH,Park JS,Cho SR

更新日期：2018-09-01 00:00:00

abstract：:ABO discrepancy refers to an inconsistency between red cell and serum typings and has various causes, including hypogammaglobulinemia. IgM deficiency is a rare disorder that may accompany several conditions such as infection and autoimmune disorders. Here, we describe a case of IgM deficiency discovered during the eva...

journal_title：Annals of laboratory medicine

authors： Jung CL,Cha MK,Jun BH,Hong KS

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:False-positive fecal immunochemical test (FIT) results in the National Cancer Screening Program (NCSP) for colorectal cancer may lead to unnecessary procedures, such as colonoscopies, increasing the medical costs. We estimated reductions in the cost of National Health Insurance according to the accreditation...

journal_title：Annals of laboratory medicine

authors： Jun JK,Sung NY,Song SH,Hong S,Jang MA,Song J,Kim JH,Min WK,Lee YK

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:In the past, ABO incompatibility was an absolute contraindication for solid organ transplantation. However, multiple recent trials have suggested strategies for overcoming the reactions between graft antigens and recipient antibodies that cause graft rejection. In this study, we determined the usefulness of ...

journal_title：Annals of laboratory medicine

authors： Yoo S,Lee EY,Huh KH,Kim MS,Kim YS,Kim HO

更新日期：2012-07-01 00:00:00

abstract：:Candidemia due to uncommon Candida spp. appears to be increasing in incidence. C. dubliniensis has been increasingly recovered from individuals not infected with HIV. Identification of C. dubliniensis can be problematic in routine clinical practice due to its phenotypic resemblance to C. albicans. We report the first ...

journal_title：Annals of laboratory medicine

authors： Yu N,Kim HR,Lee MK

更新日期：2012-05-01 00:00:00