Simultaneous determination of pethidine (meperidine), phenoperidine, and norpethidine (normeperidine), their common metabolite, by gas chromatography with selective nitrogen detection.

Abstract:

:This article describes a selective gas chromatographic method for the resolution and quantification of phenoperidine and its two metabolites, pethidine (meperidine) and norpethidine (normeperidine). Drugs and SKF 525 A, the internal standard, are separated from plasma by solvent extraction under alkaline conditions. They are chromatographed on a 3% OV-17 Chromosorb Q glass column and detected with a nitrogen-phosphorous detector. Linearity is observed in the study range (5-200 ng/ml). No interference by endogenous substances is noted.

journal_name

Forensic Sci Int

authors

Kintz P,Godelar B,Mangin P,Lugnier AA,Chaumont AJ

doi

10.1016/0379-0738(89)90154-0

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

267-73

issue

3

eissn

0379-0738

issn

1872-6283

pii

0379-0738(89)90154-0

journal_volume

43

pub_type

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