Lanreotide and its Potential Applications in Polycystic Kidney and Liver Diseases.

Abstract:

:Multiple Gαi protein-coupled somatostatin receptors (SSTRs) are expressed in human kidney and liver tissues. Also, aberrant cAMP signaling has been shown to play a critical role in cysto-genesis and enlargement of the human kidney and liver. Thus, somatostatin (SST) analogs become potential and promising alternatives in treating human polycystic kidney disease (PKD) and polycystic liver disease (PLD) via interacting with Gαi protein-coupled SSTRs and further blocking cAMP production. Lanreotide is a synthetic, long-acting SST analog with high binding affinity to SSTR2, and has been clinically approved for the treatment of acromegaly due to excessive growth hormone. Recently, this SST analog has been applied in the treatment of PKD and PLD, and has shown an effective reduction of liver and kidney volume compared to placebo. This review will discuss the discovery of this peptide and its clinical applications in the treatment of PKD/PLD patients.

journal_name

Curr Top Med Chem

authors

Sun L,Yu CY,Mackey LV,Coy DH

doi

10.2174/1568026615666150701115157

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

133-40

issue

2

eissn

1568-0266

issn

1873-4294

pii

CTMC-EPUB-68453

journal_volume

16

pub_type

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