Hepcidin and its potential clinical utility.

Abstract:

:A number of pathophysiological conditions are related to iron metabolism disturbances. Some of them are well known, others are newly discovered or special. Hepcidin is a newly identified iron metabolism regulating hormone, which could be a promising biomarker for many disorders. In this review, we provide background information about mammalian iron metabolism, cellular iron trafficking, and the regulation of expression of hepcidin. Beside these molecular biological processes, we summarize the methods that have been used to determine blood and urine hepcidin levels and present those pathological conditions (cancer, inflammation, neurological disorders) when hepcidin measurement may have clinical relevance.

journal_name

Cell Biol Int

authors

Miseta A,Nagy J,Nagy T,Poór VS,Fekete Z,Sipos K

doi

10.1002/cbin.10505

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1191-202

issue

11

eissn

1065-6995

issn

1095-8355

journal_volume

39

pub_type

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