Abstract:
:A number of pathophysiological conditions are related to iron metabolism disturbances. Some of them are well known, others are newly discovered or special. Hepcidin is a newly identified iron metabolism regulating hormone, which could be a promising biomarker for many disorders. In this review, we provide background information about mammalian iron metabolism, cellular iron trafficking, and the regulation of expression of hepcidin. Beside these molecular biological processes, we summarize the methods that have been used to determine blood and urine hepcidin levels and present those pathological conditions (cancer, inflammation, neurological disorders) when hepcidin measurement may have clinical relevance.
journal_name
Cell Biol Intjournal_title
Cell biology internationalauthors
Miseta A,Nagy J,Nagy T,Poór VS,Fekete Z,Sipos Kdoi
10.1002/cbin.10505subject
Has Abstractpub_date
2015-11-01 00:00:00pages
1191-202issue
11eissn
1065-6995issn
1095-8355journal_volume
39pub_type
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