The neuropeptide tachykinin is essential for pheromone detection in a gustatory neural circuit.

abstract：:The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex. Leveraging an ultra-high-resolution histological reconstruction of ...

journal_title：eLife

authors： Paquola C,Benkarim O,DeKraker J,Larivière S,Frässle S,Royer J,Tavakol S,Valk S,Bernasconi A,Bernasconi N,Khan A,Evans AC,Razi A,Smallwood J,Bernhardt BC

更新日期：2020-11-04 00:00:00

abstract：:Grid cells in the brain respond when an animal occupies a periodic lattice of 'grid fields' during navigation. Grids are organized in modules with different periodicity. We propose that the grid system implements a hierarchical code for space that economizes the number of neurons required to encode location with a giv...

journal_title：eLife

authors： Wei XX,Prentice J,Balasubramanian V

更新日期：2015-09-03 00:00:00

abstract：:In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Kandela et al., 2015) that described how we intended to replicate selected experiments from the paper "BET bromodomain inhibition as a therapeutic strategy to target c-Myc" (Delmore et al., 2011). Here we report the resu...

journal_title：eLife

authors： Aird F,Kandela I,Mantis C,Reproducibility Project: Cancer Biology.

更新日期：2017-01-19 00:00:00

abstract：:Dorsal/ventral (DV) patterning of the sea urchin embryo relies on a ventrally-localized organizer expressing Nodal, a pivotal regulator of the DV gene regulatory network. However, the inceptive mechanisms imposing the symmetry-breaking are incompletely understood. In Paracentrotus lividus, the Hbox12 homeodomain-conta...

journal_title：eLife

authors： Cavalieri V,Spinelli G

更新日期：2014-12-02 00:00:00

abstract：:Although activation/deactivation of specific brain regions has been shown to be predictive of successful memory encoding, the relationship between time-varying large-scale brain networks and fluctuations of memory encoding performance remains unclear. Here, we investigated time-varying functional connectivity patterns...

journal_title：eLife

authors： Keerativittayayut R,Aoki R,Sarabi MT,Jimura K,Nakahara K

更新日期：2018-06-18 00:00:00

abstract：:Optical imaging has become a powerful tool for studying brains in vivo. The opacity of adult brains makes microendoscopy, with an optical probe such as a gradient index (GRIN) lens embedded into brain tissue to provide optical relay, the method of choice for imaging neurons and neural activity in deeply buried brain s...

journal_title：eLife

authors： Meng G,Liang Y,Sarsfield S,Jiang WC,Lu R,Dudman JT,Aponte Y,Ji N

更新日期：2019-01-04 00:00:00

abstract：:Burkholderia thailandensis uses acyl-homoserine lactone-mediated quorum sensing systems to regulate hundreds of genes. Here we show that cell-cell contact-dependent type VI secretion (T6S) toxin-immunity systems are among those activated by quorum sensing in B. thailandensis. We also demonstrate that T6S is required t...

journal_title：eLife

authors： Majerczyk C,Schneider E,Greenberg EP

更新日期：2016-05-16 00:00:00

abstract：:The canonical action of the p85α regulatory subunit of phosphatidylinositol 3-kinase (PI3K) is to associate with the p110α catalytic subunit to allow stimuli-dependent activation of the PI3K pathway. We elucidate a p110α-independent role of homodimerized p85α in the positive regulation of PTEN stability and activity. ...

journal_title：eLife

authors： Cheung LW,Walkiewicz KW,Besong TM,Guo H,Hawke DH,Arold ST,Mills GB

更新日期：2015-07-29 00:00:00

abstract：:Recent findings indicate a high level of specialization at the level of microcircuits and cell populations within brain structures with regards to the control of fear and anxiety. The hippocampus, however, has been treated as a unitary structure in anxiety and fear research despite mounting evidence that different hip...

journal_title：eLife

authors： Engin E,Smith KS,Gao Y,Nagy D,Foster RA,Tsvetkov E,Keist R,Crestani F,Fritschy JM,Bolshakov VY,Hajos M,Heldt SA,Rudolph U

更新日期：2016-03-14 00:00:00

abstract：:Over the past century, soybean oil (SBO) consumption in the United States increased dramatically. The main SBO fatty acid, linoleic acid (18:2), inhibits in vitro the growth of lactobacilli, beneficial members of the small intestinal microbiota. Human-associated lactobacilli have declined in prevalence in Western micr...

journal_title：eLife

authors： Di Rienzi SC,Jacobson J,Kennedy EA,Bell ME,Shi Q,Waters JL,Lawrence P,Brenna JT,Britton RA,Walter J,Ley RE

更新日期：2018-03-27 00:00:00

abstract：:In the retina, synaptic transmission between photoreceptors and downstream ON-bipolar neurons (ON-BCs) is mediated by a GPCR pathway, which plays an essential role in vision. However, the mechanisms that control signal transmission at this synapse and its relevance to behavior remain poorly understood. In this study w...

journal_title：eLife

authors： Sarria I,Pahlberg J,Cao Y,Kolesnikov AV,Kefalov VJ,Sampath AP,Martemyanov KA

更新日期：2015-04-16 00:00:00

abstract：:Genomic sequencing has implicated large numbers of genes and de novo mutations as potential disease risk factors. A high throughput in vivo model system is needed to validate gene associations with pathology. We developed a Drosophila-based functional system to screen candidate disease genes identified from Congenital...

journal_title：eLife

authors： Zhu JY,Fu Y,Nettleton M,Richman A,Han Z

更新日期：2017-01-20 00:00:00

abstract：:Vertebrate embryonic patterning depends on signaling from Nodal, a TGFβ superfamily member. There are three Nodal orthologs in zebrafish; southpaw directs left-right asymmetries, while squint and cyclops function earlier to pattern mesendoderm. TGFβ member Vg1 is implicated in mesoderm formation but the role of the ze...

journal_title：eLife

authors： Pelliccia JL,Jindal GA,Burdine RD

更新日期：2017-11-15 00:00:00

abstract：:The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two m...

journal_title：eLife

authors： Patwardhan A,Brandt R,Butcher SJ,Collinson L,Gault D,Grünewald K,Hecksel C,Huiskonen JT,Iudin A,Jones ML,Korir PK,Koster AJ,Lagerstedt I,Lawson CL,Mastronarde D,McCormick M,Parkinson H,Rosenthal PB,Saalfeld S,Saibil

更新日期：2017-07-06 00:00:00

abstract：:B-cell receptors form ordered clusters to recruit kinases and exclude phosphatases. ...

journal_title：eLife

authors： Bálint Š,Dustin ML

更新日期：2017-03-30 00:00:00

abstract：:Clustering of receptors associated with immunoreceptor tyrosine-based activation motifs (ITAMs) initiates the macrophage antimicrobial response. ITAM receptors engage Src-family tyrosine kinases (SFKs) to initiate phagocytosis and macrophage activation. Macrophages also encounter nonpathogenic molecules that cluster r...

journal_title：eLife

authors： Freedman TS,Tan YX,Skrzypczynska KM,Manz BN,Sjaastad FV,Goodridge HS,Lowell CA,Weiss A

更新日期：2015-10-30 00:00:00

abstract：:Understanding how virus capsids assemble around their nucleic acid (NA) genomes could promote efforts to block viral propagation or to reengineer capsids for gene therapy applications. We develop a coarse-grained model of capsid proteins and NAs with which we investigate assembly dynamics and thermodynamics. In contra...

journal_title：eLife

authors： Perlmutter JD,Qiao C,Hagan MF

更新日期：2013-06-14 00:00:00

abstract：:Innate lymphoid cells (ILCs) contribute to host defence and tissue repair but can induce immunopathology. Recent work has revealed tissue-specific roles for ILCs; however, the question of how a small population has large effects on immune homeostasis remains unclear. We identify two mechanisms that ILC3s utilise to ex...

journal_title：eLife

authors： Pearson C,Thornton EE,McKenzie B,Schaupp AL,Huskens N,Griseri T,West N,Tung S,Seddon BP,Uhlig HH,Powrie F

更新日期：2016-01-18 00:00:00

abstract：:Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between cell types within a mixed population can be challenging due to the rapid turnover of metabolites relative to the time needed to isolate cells. To overcome this cha...

journal_title：eLife

authors： Lau AN,Li Z,Danai LV,Westermark AM,Darnell AM,Ferreira R,Gocheva V,Sivanand S,Lien EC,Sapp KM,Mayers JR,Biffi G,Chin CR,Davidson SM,Tuveson DA,Jacks T,Matheson NJ,Yilmaz O,Vander Heiden MG

更新日期：2020-07-10 00:00:00

abstract：:Claims that magnetic fields can be used to manipulate biological systems contradict some basic laws of physics. ...

journal_title：eLife

authors： Anikeeva P,Jasanoff A

更新日期：2016-09-08 00:00:00

abstract：:The expression of E-Cadherin, a protein best known for its role in cell adhesion, regulates the onset of embryonic differentiation. ...

journal_title：eLife

authors： Sancho M,Rodríguez TA

更新日期：2013-12-17 00:00:00

abstract：:Dengue Virus (DENV), a flavivirus spread by mosquito vectors, can cause vascular leakage and hemorrhaging. However, the processes that underlie increased vascular permeability and pathological plasma leakage during viral hemorrhagic fevers are largely unknown. Mast cells (MCs) are activated in vivo during DENV infecti...

journal_title：eLife

authors： St John AL,Rathore AP,Raghavan B,Ng ML,Abraham SN

更新日期：2013-04-30 00:00:00

abstract：:During land plant evolution, determinate spore-bearing axes (retained in extant bryophytes such as mosses) were progressively transformed into indeterminate branching shoots with specialized reproductive axes that form flowers. The LEAFY transcription factor, which is required for the first zygotic cell division in mo...

journal_title：eLife

authors： Plackett AR,Conway SJ,Hewett Hazelton KD,Rabbinowitsch EH,Langdale JA,Di Stilio VS

更新日期：2018-10-24 00:00:00

abstract：:The connection between gene loss and the functional adaptation of retained proteins is still poorly understood. We apply phylogenomics and metabolic modeling to detect bacterial species that are evolving by gene loss, with the finding that Actinomycetaceae genomes from human cavities are undergoing sizable reductions,...

journal_title：eLife

authors： Juárez-Vázquez AL,Edirisinghe JN,Verduzco-Castro EA,Michalska K,Wu C,Noda-García L,Babnigg G,Endres M,Medina-Ruíz S,Santoyo-Flores J,Carrillo-Tripp M,Ton-That H,Joachimiak A,Henry CS,Barona-Gómez F

更新日期：2017-03-31 00:00:00

abstract：:Anxiety results in sub-optimal motor learning, but the precise mechanisms through which this effect occurs remain unknown. Using a motor sequence learning paradigm with separate phases for initial exploration and reward-based learning, we show that anxiety states in humans impair learning by attenuating the update of ...

journal_title：eLife

authors： Sporn S,Hein T,Herrojo Ruiz M

更新日期：2020-05-19 00:00:00

abstract：:Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such an approach due to its conserved neuronal architecture, recently completed dense connectome,...

journal_title：eLife

authors： Li F,Lindsey JW,Marin EC,Otto N,Dreher M,Dempsey G,Stark I,Bates AS,Pleijzier MW,Schlegel P,Nern A,Takemura SY,Eckstein N,Yang T,Francis A,Braun A,Parekh R,Costa M,Scheffer LK,Aso Y,Jefferis GS,Abbott LF,Litwi

更新日期：2020-12-14 00:00:00

abstract：:Hepcidin is the master regulator of systemic iron homeostasis. Derived primarily from the liver, it inhibits the iron exporter ferroportin in the gut and spleen, the sites of iron absorption and recycling respectively. Recently, we demonstrated that ferroportin is also found in cardiomyocytes, and that its cardiac-spe...

journal_title：eLife

authors： Lakhal-Littleton S,Wolna M,Chung YJ,Christian HC,Heather LC,Brescia M,Ball V,Diaz R,Santos A,Biggs D,Clarke K,Davies B,Robbins PA

更新日期：2016-11-29 00:00:00

abstract：:CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells and show that it associates with the CDK-Mediator complex. We discov...

journal_title：eLife

authors： Dimitrova E,Kondo T,Feldmann A,Nakayama M,Koseki Y,Konietzny R,Kessler BM,Koseki H,Klose RJ

更新日期：2018-05-29 00:00:00

abstract：:Using knowledge of the structure of the world to infer value is at the heart of model-based reasoning and relies on a circuit that includes the orbitofrontal cortex (OFC). Some accounts link this to the representation of biological significance or value by neurons in OFC, while other models focus on the representation...

journal_title：eLife

authors： Sadacca BF,Wied HM,Lopatina N,Saini GK,Nemirovsky D,Schoenbaum G

更新日期：2018-03-07 00:00:00

abstract：:Kinesin super family protein 2A (KIF2A), an ATP-dependent microtubule (MT) destabilizer, regulates cell migration, axon elongation, and pruning in the developing nervous system. KIF2A mutations have recently been identified in patients with malformed cortical development. However, postnatal KIF2A is continuously expre...

journal_title：eLife

authors： Homma N,Zhou R,Naseer MI,Chaudhary AG,Al-Qahtani MH,Hirokawa N

更新日期：2018-01-09 00:00:00