Protective and sensitive effects of melatonin combined with adriamycin on ER+ (estrogen receptor) breast cancer.

Abstract:

OBJECTIVE:This study aims to investigate the protective and sensitive effects of melatonin (MLT) in the treatment of breast cancer. MATERIALS AND METHODS:ER+ breast cancer rat model was established and then rats were randomly divided into five different groups as follows: control group, Diss group, adriamycin (ADM) group, MLT group, and MLT combined with adriamycin (M+A) group. Tumor weights and one month survival rate were compared among these groups. In addition, changes of tumor tissues and expression of E-cadherin were observed under optical microscopy or electro-microscopy. RESULTS:Tumor weights were significantly lighter in M+A group than those in ADM group (p < 0.05). Under optical and electro-microscopy, tumor cell apoptosis was obviously increased in MLT group, and tumor cell injury was more severe in M+A group than that in ADM group; additionally, expression of E-cadherin was higher in MLT group and M+A group than that in other groups. Moreover, MLT group had the highest one month survival rate (100%), there was the poorest life quality in ADM group, but the best life quality in MLT. CONCLUSION:MLT could enhance the sensitivity of tumor to ADM in vivo and improve patient's life quality.

journal_name

Eur J Gynaecol Oncol

authors

Ma C,Li LX,Zhang Y,Xiang C,Ma T,Ma ZQ,Zhang ZP

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

197-202

issue

2

eissn

0392-2936

issn

2709-0086

journal_volume

36

pub_type

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