A Novel Direct Factor Xa Inhibitory Peptide with Anti-Platelet Aggregation Activity from Agkistrodon acutus Venom Hydrolysates.

abstract：:Reef sharks are vulnerable predators experiencing severe population declines mainly due to overexploitation. However, beyond direct exploitation, human activities can produce indirect or sub-lethal effects such as behavioral alterations. Such alterations are well known for terrestrial fauna but poorly documented for m...

journal_title：Scientific reports

authors： Juhel JB,Vigliola L,Wantiez L,Letessier TB,Meeuwig JJ,Mouillot D

更新日期：2019-02-27 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Mücke T,Hapfelmeier A,Schmidt LH,Fichter AM,Kanatas A,Wolff KD,Ritschl LM

更新日期：2020-02-28 00:00:00

abstract：:Toll-like receptor 9 (TLR9) is crucial to the host immune response against fungi, such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, but its importance in Cryptococcus gattii infection is unknown. Our study aimed to understand the role of TLR9 during the course of experimental C. gattii infec...

journal_title：Scientific reports

authors： da Silva-Junior EB,Firmino-Cruz L,Guimarães-de-Oliveira JC,De-Medeiros JVR,de Oliveira Nascimento D,Freire-de-Lima M,de Brito-Gitirana L,Morrot A,Previato JO,Mendonça-Previato L,Decote-Ricardo D,de Matos Guedes HL,Freire-de-Lima

更新日期：2021-01-14 00:00:00

abstract：:Bumblebees are exposed to pesticides applied for crop protection while foraging on treated plants, with increasing evidence suggesting that this sublethal exposure has implications for pollinator declines. The challenges of navigating and learning to manipulate many different flowers underline the critical role learni...

journal_title：Scientific reports

authors： Stanley DA,Smith KE,Raine NE

更新日期：2015-11-16 00:00:00

abstract：:We investigate the Lorentz-covariant deformed algebra for Dirac oscillator problem, which is a generalization of Kempf deformed algebra in 3 + 1 dimension of space-time, where Lorentz symmetry are preserved. The energy spectrum of the system is analyzed by taking advantage of the corresponding wave functions with expl...

journal_title：Scientific reports

authors： Betrouche M,Maamache M,Choi JR

更新日期：2013-11-14 00:00:00

abstract：:While TLR-activated pathways are key regulators of B cell responses in mammals, their impact on teleost B cells are scarcely addressed. Here, the potential of Atlantic salmon B cells to respond to TLR ligands was shown by demonstrating a constitutive expression of nucleic-acid sensing TLRs in magnetic sorted IgM+ cell...

journal_title：Scientific reports

authors： Jenberie S,Thim HL,Sunyer JO,Skjødt K,Jensen I,Jørgensen JB

更新日期：2018-02-23 00:00:00

abstract：:Osteochondral defects contain damage to both the articular cartilage and underlying subchon- dral bone, which remains a significant challenge in orthopedic surgery. Layered structure of bone, cartilage and the bone-cartilage interface must be taken into account in the case of biofabrication of the osteochondral (OC) i...

journal_title：Scientific reports

authors： Ayan B,Wu Y,Karuppagounder V,Kamal F,Ozbolat IT

更新日期：2020-08-04 00:00:00

abstract：:An increase in mechanical load in the heart causes cardiac hypertrophy, either physiologically (heart development, exercise and pregnancy) or pathologically (high blood pressure and heart-valve regurgitation). Understanding cardiac hypertrophy is critical to comprehending the mechanisms of heart development and treatm...

journal_title：Scientific reports

authors： Yang H,Schmidt LP,Wang Z,Yang X,Shao Y,Borg TK,Markwald R,Runyan R,Gao BZ

更新日期：2016-02-10 00:00:00

abstract：:FMS-like tyrosine kinase 3 (FLT3) is a key driver of acute myeloid leukemia (AML). Several tyrosine kinase inhibitors (TKIs) targeting FLT3 have been evaluated clinically, but their effects are limited when used in monotherapy due to the emergence of drug-resistance. Thus, a better understanding of drug-resistance pat...

journal_title：Scientific reports

authors： Morales ML,Arenas A,Ortiz-Ruiz A,Leivas A,Rapado I,Rodríguez-García A,Castro N,Zagorac I,Quintela-Fandino M,Gómez-López G,Gallardo M,Ayala R,Linares M,Martínez-López J

更新日期：2019-12-09 00:00:00

abstract：:Melanoma patients' plasma contains exosomes produced by malignant and normal cells. Plasma exosomes were isolated and separated by immunocapture into two fractions: melanoma cell-derived exosomes (MTEX) and normal cell-derived exosomes (non-MTEX). Immunosuppressive effects of MTEX on primary human immune cells were ev...

journal_title：Scientific reports

authors： Sharma P,Diergaarde B,Ferrone S,Kirkwood JM,Whiteside TL

更新日期：2020-01-09 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Taheri S,Abdullah TL,Rafii MY,Harikrishna JA,Werbrouck SPO,Teo CH,Sahebi M,Azizi P

更新日期：2019-11-05 00:00:00

abstract：:Viruses use a strategy of high mutational rates to adapt to environmental and therapeutic pressures, circumventing the deleterious effects of random single-point mutations by coevolved compensatory mutations, which restore protein fold, function or interactions damaged by initial ones. This mechanism has been identifi...

journal_title：Scientific reports

authors： Khwaja A,Galilee M,Marx A,Alian A

更新日期：2016-04-22 00:00:00

abstract：:This paper reports a facile and green method for conversion of graphene oxide (GO) into graphene by low-temperature heating (80 °C) in the presence of a glass wafer. Compared to conventional GO chemical reduction methods, the presented approach is easy-scalable, operationally simple, and based on the use of a non-toxi...

journal_title：Scientific reports

authors： Rabchinskii MK,Dideikin AT,Kirilenko DA,Baidakova MV,Shnitov VV,Roth F,Konyakhin SV,Besedina NA,Pavlov SI,Kuricyn RA,Lebedeva NM,Brunkov PN,Vul' AY

更新日期：2018-09-20 00:00:00

abstract：:Alcohol consumption is one of the major causes of hepatic steatosis, fibrosis, cirrhosis, and superimposed hepatocellular carcinoma. Ethanol metabolism alters the NAD(+)/NADH ratio, thereby suppressing the activity of sirtuin family proteins, which may affect lipid metabolism in liver cells. However, it is not clear h...

journal_title：Scientific reports

authors： Yu JH,Song SJ,Kim A,Choi Y,Seok JW,Kim HJ,Lee YJ,Lee KS,Kim JW

更新日期：2016-07-11 00:00:00

abstract：:Extreme weather events (e.g., cyclones, floods, droughts) are capable of changing ecosystems and altering how animals obtain resources. Understanding the behavioural responses of animals being impacted by these natural events can help initiate and ameliorate conservation or management programs. This study investigated...

journal_title：Scientific reports

authors： Matley JK,Eanes S,Nemeth RS,Jobsis PD

更新日期：2019-10-03 00:00:00

abstract：:This study aims to identify a panel of blood-cell neuroplasticity-related genes expressed following environmental enrichment stimulation (EE). The Drug detection (DD) training course was an excellent model for the study of EE in the working dog. This research is divided into two experimental trials. In the First Trial...

journal_title：Scientific reports

authors： Guelfi G,Casano AB,Menchetti L,Bellicci M,Suvieri C,Moscati L,Carotenuto P,Santoro MM,Diverio S

更新日期：2019-05-06 00:00:00

abstract：:Heparin is a widely used anticoagulant which inhibits factor Xa and thrombin through potentiation of antithrombin. We recently identified that the nucleic acid stain SYTOX reacts with platelet polyphosphate due to molecular similarities, some of which are shared by heparin. We attempted to study heparin in flowing blo...

journal_title：Scientific reports

authors： de Vries JC,Barendrecht AD,Clark CC,Urbanus RT,Boross P,de Maat S,Maas C

更新日期：2019-12-04 00:00:00

abstract：:Here, we present a fast mix-and-measure immunoassay for the specific semiquantitative detection of His-tagged proteins, for example in E. coli cell lysate. The assay is based on Förster resonance energy transfer (FRET) between a lanthanide dye-labeled low-affinity His-peptide and an acceptor-labeled anti-His-tag antib...

journal_title：Scientific reports

authors： Kreisig T,Prasse AA,Zscharnack K,Volke D,Zuchner T

更新日期：2014-07-08 00:00:00

abstract：:Capable of generating plasmonic and other effects, gold nanostructures can offer a variety of diagnostic and therapy functionalities for biomedical applications, but conventional chemically-synthesized Au nanomaterials cannot always match stringent requirements for toxicity levels and surface conditioning. Laser-synth...

journal_title：Scientific reports

authors： Bailly AL,Correard F,Popov A,Tselikov G,Chaspoul F,Appay R,Al-Kattan A,Kabashin AV,Braguer D,Esteve MA

更新日期：2019-09-09 00:00:00

abstract：:A retrospective immunohistochemical study was designed to investigate the frequency of concomitant traditional infectious disease pathogens in puppies that died suddenly and review the aspects of associated pathogenesis. Fifteen puppies were evaluated; the pathology reports and histopathologic slides of these animals ...

journal_title：Scientific reports

authors： Headley SA,Oliveira TES,Pereira AHT,Moreira JR,Michelazzo MMZ,Pires BG,Marutani VHB,Xavier AAC,Di Santis GW,Garcia JL,Alfieri AA

更新日期：2018-09-07 00:00:00

abstract：:To identify a vegetation configuration pattern with a high-efficiency purification ability for total nitrogen (TN), available nitrogen (AN), total phosphorous (TP), available phosphorous (AP), and chemical oxygen demand (COD) based on comprehensive assessment results, a water discharge experiment was performed in the ...

journal_title：Scientific reports

authors： Hou G,Bi H,Yu X,Jia G,Wang D,Zhang Z,Liu Z

更新日期：2019-02-20 00:00:00

abstract：:Primary IgA nephropathy (IgAN) diagnosis is based on IgA-dominant glomerular deposits and histological scoring is done on formalin-fixed paraffin embedded tissue (FFPE) sections using the Oxford classification. Our aim was to use this underexploited resource to extract RNA and identify genes that characterize active (...

journal_title：Scientific reports

authors： Cox SN,Chiurlia S,Divella C,Rossini M,Serino G,Bonomini M,Sirolli V,Aiello FB,Zaza G,Squarzoni I,Gangemi C,Stangou M,Papagianni A,Haas M,Schena FP

更新日期：2020-09-16 00:00:00

abstract：:Selective removal of lignin and other recalcitrant compounds, collectively registered as acid-unhyrolyzable residue (AUR), results in bleaching of leaf litter, but the importance of bleaching in decomposition processes on forest soil has not been fully evaluated. The aims of this study were to elucidate the occurrence...

journal_title：Scientific reports

authors： Osono T,Hiradate S,Hobara S

更新日期：2021-01-19 00:00:00

abstract：:High fat diet (HFD)-induced metabolic disorders may lead to emotional disorders. This study aimed to explore the effect of simvastatin (SMV) and bezafibrate (BZ) on improving HFD-induced emotional changes, and tried to identify their different mechanisms. The intraperitoneal glucose tolerance test (IPGTT) was used to ...

journal_title：Scientific reports

authors： Wang H,Zhou J,Liu QZ,Wang LL,Shang J

更新日期：2017-05-24 00:00:00

abstract：:Ring-opening graft polymerization (ROGP) of L-Lactide (L-LA) is a practical method of altering the physical and chemical properties of lignocellulose. Previous studies have mainly investigated cellulose and tin-based catalysts, particularly of tin(II) 2-ethylhexanoate (Sn(oct)2), at high temperatures and reported low ...

journal_title：Scientific reports

authors： Zhang X,Wang H,Liu C,Zhang A,Ren J

更新日期：2017-04-03 00:00:00

abstract：:Scrapie is a lethal neurodegenerative disease of sheep and goats caused by the misfolding of the prion protein. Variants such as M142, D145, S146, H154, Q211, and K222 were experimentally found to increase resistance or extend scrapie incubation period in goats. We aimed to identify polymorphisms in the Afar and Arsi-...

journal_title：Scientific reports

authors： Teferedegn EY,Yaman Y,Ün C

更新日期：2020-04-24 00:00:00

abstract：:Despite advances in diabetic wound care, the significant number of amputations that occur every year demands more effective therapeutics. Herein, we offer an aminated polyethersulfone nanofiber-expanded human umbilical cord blood-derived CD34+ cells (henceforth CD34+ cells) effective therapy, tested in cutaneous wound...

journal_title：Scientific reports

authors： Kanji S,Das M,Joseph M,Aggarwal R,Sharma SM,Ostrowski M,Pompili VJ,Mao HQ,Das H

更新日期：2019-06-10 00:00:00

abstract：:VvhA, a virulent factor of Vibrio (V.) vulnificus, induces acute cell death in a destructive manner. Autophagy plays an important role in cell death, but the functional role of VvhA in autophagy-related cell death has not been elucidated yet. We found that rVvhA significantly increased LC3 puncta formation and autopha...

journal_title：Scientific reports

authors： Song EJ,Lee SJ,Lim HS,Kim JS,Jang KK,Choi SH,Han HJ

更新日期：2016-06-02 00:00:00

abstract：:Mycoplasma pneumoniae infection is conventionally diagnosed using serum antibody testing, microbial culture, and genetic testing. Recently, immunochromatography-based rapid mycoplasma antigen test kits have been developed and commercialised for rapid diagnosis of M. pneumoniae infection. However, as these kits do not ...

journal_title：Scientific reports

authors： Namkoong H,Yamazaki M,Ishizaki M,Endo I,Harada N,Aramaki M,Tanaka Y,Kaburagi S,Ichikawa M,Ohata T,Sakaguchi S,Saito F,Nakao A,Yuki H,Mitamura K

更新日期：2018-01-23 00:00:00

abstract：:The comprehension of the governing mechanism which affects device instability is one of the most important requirements for the formation of reliable oxide-thin film transistors (TFTs). However, a quantitative analysis of the dominant mechanism of device instability, which stems from charge trapping induced by defects...

journal_title：Scientific reports

authors： Kim T,Park S,Jeon S

更新日期：2017-09-19 00:00:00