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Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma.

Abstract：

:Pituitary adenoma is one of the most common intracranial neoplasms, and its genetic basis remains largely unknown. To identify genetic susceptibility loci for sporadic pituitary adenoma, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. We first analyzed genome-wide SNP data in 771 pituitary adenoma cases and 2,788 controls and then carried forward the promising variants for replication in another 2 independent sets (2,542 cases and 3,620 controls in total). We identified three new susceptibility loci below the genome-wide significance threshold (P < 5 × 10(-8)) in the combined analyses: 10p12.31 (rs2359536, P(meta) = 2.25 × 10(-10) and rs10828088, P(meta) = 6.27 × 10(-10)), 10q21.1 (rs10763170, P(meta) = 6.88 × 10(-10)) and 13q12.13 (rs17083838, P(meta) = 1.89 × 10(-8)). This study is the first GWAS to our knowledge on sporadic pituitary adenoma, and our results provide insight into the genetic basis of this disease.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Ye Z,Li Z,Wang Y,Mao Y,Shen M,Zhang Q,Li S,Zhou L,Shou X,Chen J,Song Z,Ma Z,Zhang Z,Li Y,Ye H,Huang C,Wang T,He W,Zhang Y,Xie R,Qiao N,Qiu H,Huang S,Wang M,Shen J,Wen Z,Li W,Liu K,Zhou J,Wang L,

doi

10.1038/ng.3322

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

793-7

issue

7

eissn

1061-4036

issn

1546-1718

pii

ng.3322

journal_volume

47

pub_type

杂志文章

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