Abstract:
:Interleukin-7 (IL-7) is a critical cytokine in early B and T cell development. Peripheral T cell expansion and thymopoiesis and is a result of the ongoing reconstitution from uncommitted stem cells after transplant. We investigated the efficacy of ex vivo incubated bone marrow cells treated with recombinant human IL-7 (rIL-7) on subsequent in vivo murine models of syngeneic bone marrow (BM) transplant. After ex vivo culture with rIL-7, we observed a 1½-fold increase in BM cellularity; this increase was associated with an enhanced reconstitution of bone marrow cells and thymocytes at 45 days post-transplant. In addition to increased cellularity, lymphocytes from mice transplanted with cultured rIL-7 showed enhanced proliferative responses to mitogenic stimulation. These findings suggest rIL-7 to be a promising agent for the clinical application of treating immune deficiency and enhancing immuno-hematopoietic reconstitution of the stem cell auto/allograft.
journal_name
Leuk Lymphomajournal_title
Leukemia & lymphomaauthors
Abdul-Hai A,Ben Yehuda A,Slavin S,Or Rdoi
10.3109/10428194.2015.1016935subject
Has Abstractpub_date
2015-01-01 00:00:00pages
3387-92issue
12eissn
1042-8194issn
1029-2403journal_volume
56pub_type
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