当前位置： SCI文献检索 > MEDICINE期刊下所有文献 > Should screening for colorectal neoplasm be recommended in patients at high risk for coronary heart disease: a cross-sectional study.

Should screening for colorectal neoplasm be recommended in patients at high risk for coronary heart disease: a cross-sectional study.

Abstract：

:Colorectal neoplasm (CRN) and coronary heart disease (CHD) share common risk factors. We aimed to assess the risk for CRN in patients who are at high risk for developing CHD determined by measurements, which are independent from the risk factors for CRN.This study was conducted on individuals who underwent total colonoscopic examination and were without history of CHD. Two-hundred thirty-five subjects (82 with CRN and 153 with normal colonoscopic findings) participated in the study. Colorectal carcinoma (CRC) was defined as the presence of adenocarcinoma. We measured carotid intima media thickness (CIMT), flow-mediated dilation (FMD), and calculated Framingham risk score (FRS) for all participants. An increased CIMT (≥1.0 mm), a decreased FMD (<10%), and a high FRS (>20%) were defined as high risks for developing CHD. The risk and the prevalence of CRN were analyzed in relation to the risk for developing CHD.The ratio of the patients with overall-CRN and CRC was significantly higher in individuals who are at high risk for developing CHD compared with individuals who are at low risk for developing CHD by each 3 risk estimation method (P < 0.05 for all). An increased CIMT, a decreased FMD, and a high FRS score were significantly associated with the high risk for the presence of CRC (odds ratio [OR]: 6.018, OR: 3.699, and OR: 4.120, respectively). An increased CIMT, a decreased FMD, and an intermediate FRS were significantly associated with the risk for the presence of overall-CRN (OR: 3.607, OR: 1.866 and OR: 2.889, respectively).The risk for CRN increases as the risk for developing CHD increases. It can be suggested that screening for CRN can be recommended for individuals who are at high risk for developing CHD.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Basyigit S,Ozkan S,Uzman M,Ertugrul DT,Kefeli A,Aktas B,Yeniova AO,Asilturk Z,Nazligul Y,Simsek H,Simsek G,Ayturk M,Yavuz B

doi

10.1097/MD.0000000000000793

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

e793

issue

eissn

0025-7974

issn

1536-5964

pii

00005792-201505040-00016

journal_volume

pub_type

杂志文章

在线工具

Should screening for colorectal neoplasm be recommended in patients at high risk for coronary heart disease: a cross-sectional study.