Abstract:
:CYP2C9 is the key enzyme in aromatic antiepileptic drugs (AEDs) metabolism. CYP2C9*3 is a loss of function polymorphism. This study was designed to investigate genetic association between CYP2C9*3 and aromatic AED-induced severe cutaneous adverse reactions (SCARs) in Thai children. The 37 aromatic AED-induced SCARs patients (20 phenobarbital and 17 phenytoin) and 35 tolerances (19 phenobarbital and 16 phenytoin) were enrolled. CYP2C9*3 was genotyped by allele-specific PCRs. The association between CYP2C9*3 with phenytoin-induced SCARs and phenobarbital-induced SCARs were analyzed in comparison with tolerances and healthy samples. Significant association between phenytoin-induced SCARs and CYP2C9*3 was discovered (odds ratio=14.52; 95% confidence interval (CI)=1.18-∞, P-value=0.044). CYP2C9*3 was not associated with phenobarbital-induced SCARs. This study is the first report of CYP2C9*3 association to phenytoin-induced SCARs in Thai epileptic children. The CYP2C9*3 is a reasonable predictive genetic marker to anticipate SCARs from phenytoin.
journal_name
J Hum Genetjournal_title
Journal of human geneticsauthors
Suvichapanich S,Jittikoon J,Wichukchinda N,Kamchaisatian W,Visudtibhan A,Benjapopitak S,Nakornchai S,Manuyakorn W,Mahasirimongkol Sdoi
10.1038/jhg.2015.47subject
Has Abstractpub_date
2015-08-01 00:00:00pages
413-7issue
8eissn
1434-5161issn
1435-232Xpii
jhg201547journal_volume
60pub_type
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