The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis.

abstract：:The past 10 years have seen the description of families of receptors that drive proinflammatory cytokine production in infection and tissue injury. Two major classes have been examined in the context of inflammatory joint disease--the Toll-like receptors (TLRs) and NOD-like receptors (NLRs). TLRs such as TLR2 and TLR4...

journal_title：Arthritis research & therapy

authors： McCormack WJ,Parker AE,O'Neill LA

更新日期：2009-01-01 00:00:00

abstract：:Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis (RA) by assessing a panel of T cell, macrophage, and stromal cell related cytokines an...

journal_title：Arthritis research & therapy

authors： Raza K,Falciani F,Curnow SJ,Ross EJ,Lee CY,Akbar AN,Lord JM,Gordon C,Buckley CD,Salmon M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Here we integrate verified signals from previous genetic association studies with gene expression and pathway analysis for discovery of new candidate genes and signaling networks, relevant for rheumatoid arthritis (RA). METHOD:RNA-sequencing-(RNA-seq)-based expression analysis of 377 genes from previously v...

journal_title：Arthritis research & therapy

authors： Shchetynsky K,Diaz-Gallo LM,Folkersen L,Hensvold AH,Catrina AI,Berg L,Klareskog L,Padyukov L

更新日期：2017-02-02 00:00:00

abstract：INTRODUCTION:Osteoarthritis (OA) is a degenerative disease characterized by cartilage breakdown in the synovial joints. The presence of low-grade inflammation in OA joints is receiving increasing attention, with synovitis shown to be present even in the early stages of the disease. How the synovial inflammation arises ...

journal_title：Arthritis research & therapy

authors： Sohn DH,Sokolove J,Sharpe O,Erhart JC,Chandra PE,Lahey LJ,Lindstrom TM,Hwang I,Boyer KA,Andriacchi TP,Robinson WH

更新日期：2012-01-08 00:00:00

abstract：INTRODUCTION:Soluble immune aggregates bearing intact Fc fragments are effective treatment for a variety of autoimmune disorders in mice. The better to understand the mechanisms by which Fc-bearing immune complexes suppress autoimmunity, and to develop a platform for clinical translation, we created a series of fully r...

journal_title：Arthritis research & therapy

authors： Jain A,Olsen HS,Vyzasatya R,Burch E,Sakoda Y,Mérigeon EY,Cai L,Lu C,Tan M,Tamada K,Schulze D,Block DS,Strome SE

更新日期：2012-08-20 00:00:00

abstract：BACKGROUND:Patient-reported outcomes measures, such as those provided by the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire, have been found to be a reliable indicator of change during treatment, predictive of long-term outcomes, and the impact of psoriatic arthritis (PsA) on patients' lives. The objective...

journal_title：Arthritis research & therapy

authors： Queiro R,Cañete JD,Montoro M,Gómez S,Cábez A,MAAPS study group.

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially carboxymethyl-lysine (CML). We aimed to investigate the expression of several AGEs and Glo-1 in human OA cartilage...

journal_title：Arthritis research & therapy

authors： Trellu S,Courties A,Jaisson S,Gorisse L,Gillery P,Kerdine-Römer S,Vaamonde-Garcia C,Houard X,Ekhirch FP,Sautet A,Friguet B,Jacques C,Berenbaum F,Sellam J

更新日期：2019-01-11 00:00:00

abstract：BACKGROUND:Nitric oxide and prostaglandin E2 (PGE2play pivotal roles in both the pathogenesis of osteoarthritis and catabolic processes in articular cartilage. These mediators are influenced by both IL-1beta and mechanical loading, and involve alterations in the inducible nitric oxide synthase (iNOS) and cyclo-oxygenas...

journal_title：Arthritis research & therapy

authors： Chowdhury TT,Arghandawi S,Brand J,Akanji OO,Bader DL,Salter DM,Lee DA

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:There is an ever-increasing need for animal models to evaluate efficacy and safety of new therapeutics in the field of rheumatoid arthritis (RA). Particularly for the early preclinical evaluation of human-specific biologicals targeting the progressive phase of the disease, there is a need for relevant anim...

journal_title：Arthritis research & therapy

authors： Vierboom MP,Breedveld E,Kondova I,'t Hart BA

更新日期：2010-01-01 00:00:00

abstract：:Chemokines play an essential role in the progression of rheumatoid arthritis (RA). In the present study we examined the expression and regulatory mechanisms of IFN-gamma inducible protein (IP)-10 in RA synovitis. RA synovial fluid contained greater amounts of IP-10 than did synovial fluid from patients with osteoarthr...

journal_title：Arthritis research & therapy

authors： Hanaoka R,Kasama T,Muramatsu M,Yajima N,Shiozawa F,Miwa Y,Negishi M,Ide H,Miyaoka H,Uchida H,Adachi M

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Plasmablasts and plasma cells play a key role in many autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study was undertaken to evaluate the potential of targeting CD38 as a plasma cell/plasmablast depletion mechanism by daratumumab in the treatment of patien...

journal_title：Arthritis research & therapy

authors： Cole S,Walsh A,Yin X,Wechalekar MD,Smith MD,Proudman SM,Veale DJ,Fearon U,Pitzalis C,Humby F,Bombardieri M,Axel A,Adams H 3rd,Chiu C,Sharp M,Alvarez J,Anderson I,Madakamutil L,Nagpal S,Guo Y

更新日期：2018-05-02 00:00:00

abstract：:This article is about risk. Risk is probably the most misunderstood component in determining therapeutic intervention; however, it is probably the most relevant issue to consider in the context of expected benefit. The rarity of quantitative risk-benefit assessment and the lack of comparative risk-benefit when alterna...

journal_title：Arthritis research & therapy

authors： Goldkind L,Simon LS

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in the pathogenesis of AS. We aimed to define and compare the fecal microbiota composition in patients w...

journal_title：Arthritis research & therapy

authors： Klingberg E,Magnusson MK,Strid H,Deminger A,Ståhl A,Sundin J,Simrén M,Carlsten H,Öhman L,Forsblad-d'Elia H

更新日期：2019-11-27 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages secreting high amounts of inflammatory cytokines. It is a frequent manifestation in patients with predisposing genetic defects, but can o...

journal_title：Arthritis research & therapy

authors： Bode SF,Lehmberg K,Maul-Pavicic A,Vraetz T,Janka G,Stadt UZ,Ehl S

更新日期：2012-06-08 00:00:00

abstract：INTRODUCTION:The decreased disc height characteristic of intervertebral disc (IVD) degeneration has often been linked to low back pain, and thus regeneration strategies aimed at restoring the disc extracellular matrix and ultimately disc height have been proposed as potential treatments for IVD degeneration. One such t...

journal_title：Arthritis research & therapy

authors： Le Maitre CL,Baird P,Freemont AJ,Hoyland JA

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease characterized by recurrent self-limiting fever and serositis that mainly affects Mediterranean populations. Many patients with FMF have been reported in Japan due to increasing recognition of this condition and the availability of ...

journal_title：Arthritis research & therapy

authors： Kishida D,Nakamura A,Yazaki M,Tsuchiya-Suzuki A,Matsuda M,Ikeda S

更新日期：2014-09-27 00:00:00

abstract：BACKGROUND:The detection of anti-dsDNA antibodies is critical for the diagnosis and follow-up of systemic lupus erythematosus (SLE) patients. The presently available assays are characterized by a non-optimal specificity (solid phase assays) or sensitivity (Crithidia Luciliae immunofluorescence test (CLIFT)). To overcom...

journal_title：Arthritis research & therapy

authors： Panza F,Alcaro MC,Petrelli F,Angelotti F,Pratesi F,Rovero P,Migliorini P

更新日期：2016-10-04 00:00:00

abstract：INTRODUCTION:Human cytomegalovirus (HCMV) infection has been implicated in the development of autoimmunity, including systemic lupus erythematosus (SLE). Previously we reported that HCMV phosphoprotein 65 (pp65) could induce early onset of autoantibody and glomerulonephritis on lupus-prone NZB/W mice. This study furthe...

journal_title：Arthritis research & therapy

authors： Hsieh AH,Jhou YJ,Liang CT,Chang M,Wang SL

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:In the present systematic review and meta-analysis, we assessed the effectiveness of different forms of balneotherapy (BT) and hydrotherapy (HT) in the management of fibromyalgia syndrome (FMS). METHODS:A systematic literature search was conducted through April 2013 (Medline via Pubmed, Cochrane Central R...

journal_title：Arthritis research & therapy

authors： Naumann J,Sadaghiani C

更新日期：2014-07-07 00:00:00

abstract：:Pulmonary involvement is a common complication of vasculitides, especially small vessel vasculitides. This review provides an overview of vasculitic manifestations of the lung as well as of other organs involved in vasculitides. Furthermore, it provides the diagnostic procedures required to asses a patient with vascul...

journal_title：Arthritis research & therapy

authors： Holle JU,Moosig F,Dalhoff K,Gross WL

更新日期：2011-06-30 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) has been known to be associated with increased risk of cardiovascular disease (CVD). The aim of this study was to investigate the effects of Tai Chi exercise on CVD risk in elderly women with RA. METHOD:In total, 56 female patients with RA were assigned to either a Tai Chi exercise...

journal_title：Arthritis research & therapy

authors： Shin JH,Lee Y,Kim SG,Choi BY,Lee HS,Bang SY

更新日期：2015-12-24 00:00:00

abstract：BACKGROUND:We aimed to determine whether synovial fluid (SF) biomarkers can predict the progression of articular cartilage damage as determined by arthroscopic evaluation during and after anterior cruciate ligament (ACL) reconstruction. METHODS:Arthroscopic assessment of articular cartilage damage was performed twice ...

journal_title：Arthritis research & therapy

authors： Sobue Y,Kojima T,Kurokouchi K,Takahashi S,Yoshida H,Poole R,Ishiguro N

更新日期：2017-12-06 00:00:00

abstract：INTRODUCTION:Biological markers specifically reflecting pathological processes may add value in the assessment of inter-individual variations in the course of rheumatoid arthritis (RA). The current study was undertaken to investigate whether baseline serum levels of the chemokine CXCL13 might predict clinical and ultra...

journal_title：Arthritis research & therapy

authors： Bugatti S,Manzo A,Benaglio F,Klersy C,Vitolo B,Todoerti M,Sakellariou G,Montecucco C,Caporali R

更新日期：2012-02-15 00:00:00

abstract：INTRODUCTION:Autoantibodies against mutated and citrullinated vimentin (MCV) represent a novel diagnostic marker for rheumatoid arthritis (RA). Recently, an increased sensitivity for anti-MCV compared to autoantibodies against cyclic citrullinated peptides (anti-CCP2) was shown in cohorts of patients with early RA and ...

journal_title：Arthritis research & therapy

authors： Renger F,Bang H,Feist E,Fredenhagen G,Natusch A,Backhaus M,Burmester GR,Egerer K

更新日期：2010-01-01 00:00:00

abstract：:Cardiovascular morbidity and mortality are becoming major health concerns for adults with inflammatory rheumatic diseases. The enhanced atherogenesis in this patient population is promoted by the exposure to traditional risk factors as well as nontraditional cardiovascular insults, such as corticosteroid therapy, chro...

journal_title：Arthritis research & therapy

authors： Barsalou J,Bradley TJ,Silverman ED

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Interstitial lung disease (ILD) is a common complication of connective tissue disease (CTD) and a leading cause of morbidity and mortality. There are various lung ultrasound (LUS) scoring systems with different lung intercostal spaces (LIS). The purpose of this meta-analysis was to find a simplified LUS meth...

journal_title：Arthritis research & therapy

authors： Xie HQ,Zhang WW,Sun S,Chen XM,Yuan SF,Gong ZH,Liu L

更新日期：2019-04-11 00:00:00

abstract：BACKGROUND:Antibodies and upregulated cytokines and chemokines predate the onset of rheumatoid arthritis (RA) symptoms. We aimed to identify the pathways related to the early processes leading to RA development, as well as potential novel biomarkers, using multiple protein analyses. METHODS:A case-control study was co...

journal_title：Arthritis research & therapy

authors： Brink M,Lundquist A,Alexeyenko A,Lejon K,Rantapää-Dahlqvist S

更新日期：2019-12-16 00:00:00

abstract：INTRODUCTION:Intraarticular administration of autologous conditioned serum (ACS) recently demonstrated some clinical effectiveness in treatment of osteoarthritis (OA). The current study aims to evaluate the in vitro effects of ACS on cartilage proteoglycan (PG) metabolism, its composition and the effects on synovial fl...

journal_title：Arthritis research & therapy

authors： Rutgers M,Saris DB,Dhert WJ,Creemers LB

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Methotrexate (MTX) is a cornerstone of treatment in a wide variety of inflammatory conditions, including juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM). However, owing to its narrow therapeutic index and the considerable interpatient variability in clinical response, monitoring of a...

journal_title：Arthritis research & therapy

authors： Hawwa AF,AlBawab A,Rooney M,Wedderburn LR,Beresford MW,McElnay JC

更新日期：2015-10-22 00:00:00

abstract：:We investigated the therapeutic potential and mechanism of action of IFN-beta protein for the treatment of rheumatoid arthritis (RA). Collagen-induced arthritis was induced in DBA/1 mice. At the first clinical sign of disease, mice were given daily injections of recombinant mouse IFN-beta or saline for 7 days. Disease...

journal_title：Arthritis research & therapy

authors： van Holten J,Reedquist K,Sattonet-Roche P,Smeets TJ,Plater-Zyberk C,Vervoordeldonk MJ,Tak PP

更新日期：2004-01-01 00:00:00